Volume 3.35 | Sep 8

Cord Blood News 3.35, September 8, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Direct Contact of Umbilical Cord Blood Endothelial Progenitors with Living Cardiac Tissue Is a Requirement for Vascular Tube-Like Structures Formation
Scientists employed a novel coculture system to investigate whether human endothelial progenitor cells have the capacity to integrate into living and ischaemic cardiac tissue, and participate to neovascularization. [J Cell Mol Med] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

p57Kip2 and p27Kip1 Cooperate to Maintain Hematopoietic Stem Cell Quiescence through Interactions with Heat Shock Cognate Protein 70
In this study, investigators report that cell cycle entry proceeded normally in hematopoietic stem cells null for cyclin-dependent kinase inhibitor p57 due to compensatory upregulation of p27. [Cell Stem Cell] Abstract

p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells
Results suggest that, among Cip/Kip family cyclin-dependent kinase inhibitors, p57 plays a predominant role in the quiescence and maintenance of adult hematopoietic stem cells. [Cell Stem Cell] Abstract

Cooperation Between Both Wnt/β-Catenin and PTEN/PI3K/Akt Signaling Promotes Primitive Hematopoietic Stem Cell Self-Renewal and Expansion
Using a hematopoietic stem and progenitor cell-specific conditional induction line, researchers generated a compound genetic model bearing both Pten deletion and β-catenin activation. [Genes Dev] Abstract

Differential Effects of HOXB4 and NUP98-HOXA10hd on Hematopoietic Repopulating Cells in a Nonhuman Primate Model
Researchers show that HOXB4 and NUP98-HOXA10hd (NA10hd) both have a significant impact on hematopoietic reconstitution; however, these effects are differential and therefore may offer complementary strategies for hematopoietic stem cell expansion. [Hum Gene Ther] Abstract

Manipulation of Oxygenation and Flow-Induced Shear Stress Can Increase the In Vitro Yield of Platelets from Cord Blood
Using CD34 positively selected cord blood cells, researchers investigated ways to increase platelet quality and yield in a three-dimensional modular perfusion bioreactor system. [Tissue Eng Part C Methods] Abstract

Priming of Mesenchymal Stem Cells with Oxytocin Enhances the Cardiac Repair in Ischemia/Reperfusion Injury
In this study, umbilical cord blood-derived mesenchymal stem cells were cultured with oxytocin and examined for their therapeutic effect in an infarcted heart. [Cells Tissues Organs] Abstract

Lethal Human Herpesvirus-6 Encephalitis After Cord Blood Transplant
Clinical, biological, pathological, and imaging findings were all suggestive of lethal human herpesvirus-6-associated encephalitis in a 61-year-old man who had undergone a cord blood transplant. [Transpl Infect Dis] Abstract

Effect of Human Cytomegalovirus Infection on the Expression of Hoxb2 and Hoxb4 Genes in the Developmental Process of Cord Blood Erythroid Progenitors
The aim of the study was to investigate the role of Hoxb2 and Hoxb4 gene expression induced by human cytomegalovirus and/or all-trans retinoic acid on the proliferation and committed differentiation process of human cord blood hematopoietic stem cells to colony-forming erythroid progenitor cells in vitro. [Mol Med Rep] Abstract

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INDUSTRY NEWS

Cryo-Save Switzerland Receives National Accreditation for Safe Procedures
Cryo-Save Group is proud to announce the positive review and certification of their Swiss operations by Swissmedic. [Cryo-Save Group] Press Release

Americord Registry Appoints Nationally Recognized Scientist to its Medical Advisory Board
Americord Registry announced the expansion of its Medical Advisory Board with the appointment of Dr. Eric Adler, who previously served as Interim Medical Director for the company. [Americord Registry] Press Release

Golden Meditech Celebrates Grand Opening of Taiwan Representative Office
Golden Meditech Holdings Limited, a major brand name in haematology hospital and the largest stem cell cord blood banking operator in China, is pleased to announce the launch of its Taiwan representative office. [Golden Meditech Holdings Limited] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW The Australasian Society of Stem Cell Research 4th Annual Conference
October 23-25, 2011
Leura, Australia

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 

Research and Development Technologist (STEMCELL Technologies) 

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

Postdoctoral Position (Izmir Katip Celebi University)

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