Volume 12.23 | Jun 18

2020-06-18| CNB 12.23
Cord Blood News by STEMCELL Technologies
Vol. 12.23 – 18 June, 2020
TOP STORY

Cryopreserved Human Oocytes and Cord Blood Cells Can Produce Somatic Cell Nuclear Transfer-Derived Pluripotent Stem Cells with a Homozygous HLA Type

Researchers applied a modified derivation method to the pluripotent stem cell line and first obtained human somatic cell nuclear transfer-PSC lines derived from both donated cryopreserved oocytes and cord blood cells with a homozygous human leukocyte antigen type.
[Stem Cell Reports]

Full Article

Getting enough cord blood HSCs for transplantation isn't easy. But she's paving the way. Watch Suzan Imren's webinar.
PUBLICATIONSRanked by the impact factor of the journal

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
[Cell Research]

Full Article

Allogeneic Cord Blood Transfusions Prevent Fetal Hemoglobin Depletion in Preterm Neonates. Results of the CB-TrIP Study

Investigators monitored fetal hemoglobin levels in 25 preterm neonates until 36 weeks of post‐menstrual age; patients received repeated red blood cell (RBC) units from allogeneic cord blood (cord‐RBCs) or from adult donors, depending on whether cord‐RBCs were available.
[British Journal of Haematology]

Abstract

Hypoxia-Preconditioned Placenta-Derived Mesenchymal Stem Cells Rescue Optic Nerve Axons via Differential Roles of Vascular Endothelial Growth Factor in an Optic Nerve Compression Animal Model

Scientists established a hypoxia-preconditioned strain using a hypoxic chamber. The human placenta–derived stem cells were exposed to short-term hypoxic conditions of 2.2% O2 and 5.5% CO2.
[Molecular Neurobiology]

Abstract

Plasma Membrane Vesicles of Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Acetaminophen-Induced Damage in HepG2 Cells: A Novel Stem Cell Therapy

PMVs from human umbilical cord (hUC) MSCs were prepared with an improved procedure including a chemical enucleation step followed by a mechanical extrusion. Plasma membrane vesicles of hUCMSCs were characterized and supplemented to hepatocyte cultures.
[Stem Cell Research & Therapy]

Full Article

Proteomic Profiling of Striatal Tissue of a Rat Model of Parkinson’s Disease after Implantation of Collagen-Encapsulated Human Umbilical Cord Mesenchymal Stem Cells

Human umbilical cord-MSCs were encapsulated into collagen hydrogels and implanted into the striatum of hemi‐parkinsonian male Sprague Dawley rats. One or 14 days after implantation, the area of interest was dissected using a cryostat.
[Journal of Tissue Engineering and Regenerative Medicine]

Abstract

Human Umbilical Cord Blood–Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
[Cell Biology and Toxicology]

Full Article

The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
REVIEWS

Cross Talk between Mesenchymal and Glioblastoma Stem Cells: Communication beyond Controversies

The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
[Stem Cells Translational Medicine]

Full Article

INDUSTRY AND POLICY NEWS

Emmes Announces Its Work on a Phase III Clinical Trial for Breakthrough Therapy Designation Product

Emmes announced that it provided the Phase III clinical trial support for a new investigational cell therapy that offers a promising treatment opportunity for patients who need an allogeneic bone marrow transplant.
[Emmes (PR Newswire, Inc.)]

Press Release

Hong Kong’s Contentious National Security Law Concerns Some Academics

China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News]

Editorial

FEATURED EVENT

International Society for Stem Cell Research (ISSCR) Virtual Annual Meeting 2020

2020-06-23 – 2020-06-27
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoctoral Position – Immune Privilege of the Stem Cell Niche

Columbia University – New York, New York, United States

Research Technician – Cord Blood Preperation

Duke University – Durham, North Carolina, United States

Instructor – Stem Cell Products

University of Colorado – Denver, Colorado, United States

Professor – Hematology-Oncology

Karolinska Institutet – Solna, Sweden

Postdoctoral Fellow – Cell Biology

Tulane University School of Medicine – New Orleans, Los Angeles, United States

Postdoctoral Fellow – Molecular Hematology

Heidelberg University Hospital – Heidelberg, Germany

Department Head – Hematological Cancer

Ichnos – Lausanne, Switzerland

Deputy Director – Division of Blood Diseases and Resources

NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States

Postdoctoral Position – Tumor Immunology

University of Maryland – Baltimore, Maryland, United States

Senior Scientist – Cell Engineering

Merck & Co., Inc. – Kenilworth, New Jersey, United States

Postdoctoral Researcher – Leukemia

Josep Carreras Leukaemia Research Institute – Barcelona, Spain

> See All Jobs

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