Volume 12.24 | Jun 25

2020-06-25 | CBN 12.24
Cord Blood News by STEMCELL Technologies
Vol. 12.24 – 25 June, 2020
TOP STORY

Engraftment Kinetics after Transplantation of Double Unit Cord Blood Grafts Combined with Haplo-Identical CD34+ Cells without Antithymocyte Globulin

Scientists investigated adding haplo-identical CD34+ cells to double unit cord blood (CB) grafts to facilitate early haplo-identical donor-derived neutrophil recovery prior to CB engraftment.
[Leukemia]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

A Scaffold Laden with Mesenchymal Stem Cell-Derived Exosomes for Promoting Endometrium Regeneration and Fertility Restoration through Macrophage Immunomodulation

A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
[Acta Biomaterialia]

Abstract

A Circular RNA Map for Human Induced Pluripotent Stem Cells of Fetal Origin

Reprogramming was achieved by a footprint-free strategy. Self-renewal and pluripotency of cord blood MSC-human induced pluripotent stem cells (hiPSC) were investigated in vitro and in vivo, compared to parental MSC, to embryonic stem cells and to fibroblast derived-hiPSC.
[Ebiomedicine]

Full Article

Enhanced Collection of Phenotypic and Engrafting Human Cord Blood Hematopoietic Stem Cells at 4°C

Researchers demonstrated that collecting and processing of human cord blood at 4°C within minutes of the baby’s birth results in significantly enhanced numbers of rigorously defined phenotypic hematopoietic stem cell and self‐renewing NSG immune‐deficient mouse engrafting and SCID‐repopulating cells.
[Stem Cells]

Abstract

Nanospheres Loaded with Curcumin Improve the Bioactivity of Umbilical Cord Blood-Mesenchymal Stem Cells via c-Src Activation during the Skin Wound Healing Process

Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human MSCs during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
[Cells]

AbstractDownload Full ArticleGraphical Abstract

Effect of Amniotic Fluid Stem Cell Transplantation on the Recovery of Bladder Dysfunction in Spinal Cord-Injured Rats

The effects of human amniotic fluid stem cell transplantation on bladder function and molecular changes in spinal cord-injured rats were investigated.
[Scientific Reports]

Full Article

Ursodeoxycholic Acid Improves Feto-Placental and Offspring Metabolic Outcomes in Hypercholanemic Pregnancy

Researchers analyzed the lipid profile of fetal serum from untreated intrahepatic cholestasis of pregnancy (ICP), ursodeoxycholic acid (UDCA)-treated ICP and uncomplicated pregnancies and found that UDCA ameliorated ICP-associated fetal dyslipidemia.
[Scientific Reports]

Full Article

A Flowable Placental Formulation Prevents Bleomycin-Induced Dermal Fibrosis in Aged Mice

Researchers investigated the anti-fibrotic activity of a flowable placental formulation using a bleomycin-induced dermal fibrosis model in aged mice.
[European Journal of Human Genetics]

Full Article

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REVIEWS

Regenerative Potential of Wharton’s Jelly-Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

The authors summarize the current pre-clinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]

Abstract

INDUSTRY AND POLICY NEWS

Gender Gap in Research Output Widens During Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]

Editorial

Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]

Editorial

COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]

Editorial

FEATURED EVENT

2020 Parenteral Drug Association (PDA) Virtual Pharmaceutical Manufacturing Data Science Workshop

2020-07-13 – 2020-07-16
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JOB OPPORTUNITIES

Postdoctoral Fellow – Pluripotent Stem Cell Biology and Cardiac Disease Modeling

Northwestern University – Chicago, Illinois, United States

Postdoctoral Position – Immune Privilege of the Stem Cell Niche

Columbia University – New York, New York, United States

Research Technician – Cord Blood Preperation

Duke University – Durham, North Carolina, United States

Instructor – Stem Cell Products

University of Colorado – Denver, Colorado, United States

Professor – Hematology-Oncology

Karolinska Institutet – Solna, Sweden

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