Volume 2.10 | Mar 18

Cord Blood News 2.10, March 18, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events


Differentiation and Migration Properties of Human Fetal Umbilical Cord Perivascular Cells: Potential for Lung Repair
In the perspective of a therapeutic application in chronic lung disease of pre-term newborns, researchers demonstrated the in vitro ability of human umbilical cord perivascular cells to migrate towards an alveolar type II cell line damaged with bleomycin, an anti-cancer agent with known pulmonary toxicity. [J Cell Mol Med]

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Amniotic Fluid Cells more Efficiently Reprogrammed to Pluripotency than Adult Cells
Researchers have demonstrated that skin cells found in human amniotic fluid can be efficiently “reprogrammed” to pluripotency, where they have characteristics similar to human embryonic stem cells that can develop into almost any type of cell in the human body. [Press release from the Mount Sinai School of Medicine discussing the online prepublication in Cellular Reprogramming]

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Pharmacologic Modulation of Niche Accessibility via Tyrosine Kinase Inhibition Enhances Marrow and Thymic Engraftment Following Hematopoietic Stem Cell Transplantation
Researchers conclude that transient, pharmacologic inhibition of KIT enhances accessibility of marrow and thymic niches, and provides a novel, non-cytotoxic approach to accomplish engraftment after stem cell transplantation. [Blood]

Pim2 Cooperates with PML-RAR(Alpha) to Induce Acute Myeloid Leukemia in a Bone Marrow Transplantation Model
The results support the hypothesis that Pim2, which is also a known target of Flt3-ITD (another gene that cooperates with PML-RAR{alpha}), cooperates with PML-RAR{alpha} to induce acute promyelocytic leukemia-like disease. [Blood]

Comparison of Ectopic Bone Formation of Embryonic Stem Cells and Cord Blood Stem Cells In Vivo
Cord blood stem cells in combination with insoluble collagenous bone matrix-induced ectopic bone formation in vivo are stronger than embryonic stem cells. [Tissue Eng Part A]

Enhanced Generation of Megakaryocytes from Umbilical Cord Blood-Derived CD34+ Cells Expanded in the Presence of Two Nutraceuticals, Docosahexanoic Acid and Arachidonic Acid, as Supplements to the Cytokine-Containing Medium
Use of nutraceuticals like docosahexanoic acid and arachidonic acid may prove to be a useful strategy for efficient generation of megakaryocytes and platelets from cord blood cells, for future use in clinics and basic research. [Cytotherapy]

Impact of Graft-Versus-Host Disease on Quality of Life in Long-Term Survivors of Hematopoietic Transplantation
Taking into account, that the prevalence of graft-versus-host disease might be higher in patients after peripheral blood stem cell transplant (PBSCT) compared with patients after bone marrow transplant (BMT), PBSCT is expected to lead to more severe impairments of quality of life than BMT. [Bone Marrow Transplant]

Identification of Molecular Markers for Pre-Engraftment Immune Reactions After Cord Blood Transplantation by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectroscopy
Surface-enhanced laser desorption/ionization time-of-flight mass spectroscopy system in combination with other proteomic methods could serve as a potential diagnostic tool in discovering biomarkers for pre-engraftment immune reaction after cord blood transplantation. [Bone Marrow Transplant]

Mesenchymal Stem Cells Derived from Canine Umbilical Cord Vein — A Novel Source for Cell Therapy Studies
Researchers describe the isolation of mesenchymal stem cells from canine umbilical cord vein. Their multipotent plasticity was demonstrated by their capacity to differentiate in adipocytic, chondrocytic, and osteocytic lineages. [Stem Cells Dev]

Both Interleukin-3 and Interleukin-6 Are Necessary for Better Ex Vivo Expansion of CD133+ Cells from Umbilical Cord Blood
The presence of SCF, Flt3-L, and TPO are essential for CD133+ and/or CD34+ cells ex vivo expansion; however, IL-3 and IL-6 influence has not yet been clearly established. Researchers investigated this influence on CD133+ cells from umbilical cord blood ex vivo expansion and the effect of these cytokines upon cell phenotype. [Stem Cells Dev]

Human Cord Blood Progenitors with High Aldehyde Dehydrogenase Activity Improve Vascular Density in a Model of Acute Myocardial Infarction
Data indicate that adult human stem cells do not become a significant part of the regenerating tissue, but rapidly home to and persist only temporarily at the site of hypoxic injury to exert paracrine effects on tissue repair thereby enhancing vascular recovery. [J Transl Med]

MHC Class II Deficiency Cured by Unrelated Mismatched Umbilical Cord Blood Transplantation: Case Report and Review of 68 Cases in the Literature
MHC II deficiency was caused by an RFXANK-mutation and treated successfully by 4/6 mismatched unrelated cord blood transplant after a myeloablative conditioning regimen based on anti-thymocyte globulin, busulfane, fludarabine, and cyclophosphamide. [Pediatr Transplant]


Half a Million for Gene Sequencers
The 10th annual Albany Medical Center Prize — the U.S.’s biggest prize in biomedicine — will go to three scientists who conceptualized the Human Genome Project: Francis Collins, Eric Lander, and David Botstein. [ScienceInsider]

ThermoGenesis Signs Asia Distribution Agreement with Fenwal for BioArchive and AXP Systems
Under the exclusive five-year agreement, Fenwal will market and distribute the ThermoGenesis AXP® AutoXpress™ System and BioArchive® System for use in cord blood processing and storage in China, India and Japan. [ThermoGenesis Corp. Press Release]

University of Illinois at Chicago Opens New Sickle Cell Treatment Center
Clinic allows patients suffering pain crisis, without complications such as shortness of breath, numbness or fever, to get immediate, specialized care. [Chicago Tribute]

Cord-Blood Banks Oversell Value
Health claims made by private cord-blood banks to persuade parents to save their baby’s umbilical cord blood can overstate the benefits, according to an investigation by CBC-TV’s Marketplace. [CBC News]

Northeast Ohio Program Expands, Seeks More Donations of Newborn Cord Blood
A nonprofit program is trying to expand throughout Northeast Ohio so more parents can donate their babies’ potentially life-saving gift of umbilical cord blood. [Beacon Journal]


Human Tissue Authority Voices Concerns Over Unlawful Cord Blood Collection
The Human Tissue Authority is writing to over 150 organizations to warn of concerns that unlawful umbilical cord blood collection may compromise safety and quality standards. [Human Tissue Authority, United Kingdom]

California Institute for Regenerative Medicine Allocates $50 Million for Stem Cell Therapy Development, a Boost for the State’s Growing Stem Cell Industry
In a move that will speed the path of bringing stem cell-based therapies to the people of California, the Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by Proposition 71, approved a concept proposal for funding the development of new stem cell therapies. [California Institute for Regenerative Medicine, United States]

Spain Turns to Science for Stimulus
Spain’s ministers recently approved the text of a new research law that aims to reward scientific talent and encourage entrepreneurship. [Science and Innovation Ministry, Spain]

Japan Maps Out Big Science Plans
For the first time ever, Japanese scientists have produced a roadmap of where they see major research programs heading in the mid-term — about 10 years out — and a list of large-scale facilities they will need to get there. [Science Council of Japan, Japan]

Red Tape Holding Up Stem Cell Work?
Rigorous new paperwork requirements for getting a cell line listed in the National Institutes of Health stem cell registry — the only lines federally-funded researchers can use — have delayed the listing of several lines derived at the University of Wisconsin. [ScienceInsider]

Food and Drug Administration Transparency Task Force; Request for Comments [Docket No. FDA-2009-N-0247] [Food and Drug Administration, United States]

Agency Information Collection Activities; Proposed Collection; Comment Request; Human Cells, Tissues, and Cellular and Tissue-Based Products: Establishment Registration and Listing; Form FDA 3356; Eligibility Determination for Donors; and Current Good Tissue Practice [Docket No. FDA-2010-N-0101] [Food and Drug Administration, United States]

Blood Products Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Technical Assistance for RFA-RM-10-006: Advancing Regulatory Science through Novel Research and Science-Based Technologies (U01) (NOT-RM-10-003) [National Institutes of Health, United States]

Modification: This Notice Modifies RFA-RM-09-019 (NOT-RM-10-004) [National Institutes of Health, United States]

Notice of a Change in the Next Receipt Date for the Center of Biomedical Research Excellence Program Announcement (PAR-09-079) (NOT-RR-10-005) [National Institutes of Health, United States]

Notice of Intent to Publish a Funding Opportunity for the Reissue of RFA-TW-08-002 the International Research Ethics Education and Curriculum Development Award (R25) (NOT-TW-10-326) [National Institutes of Health, United States]

Collaborative Research for Molecular and Genomic Studies of Behavior in Animal Models (R01) (PA-10-125) [National Institutes of Health, United States]

Biologic Product Shortages [Center for Biologics Evaluation and Research, United States]


36th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT)
March 21-24, 2010
Vienna, Austria

12th Biennial Canadian Blood and Marrow Transplant Group (CBMTG) Conference
April 7-10, 2010
Vancouver, Canada

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

British Society for Haematology 50th Annual Scientific Meeting
April 19-21, 2010
Edinburgh, Scotland

XXIII International Symposium on Technological Innovations in Laboratory Hematology
May 10-12, 2010
Brighton, United Kingdom

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States 

8th Annual International Umbilical Cord Blood Transplantation Symposium
June 3-5, 2010
San Francisco, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

Select Bioscience’s World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

International Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

American Association of Blood Banks (AABB) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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