Volume 2.17 | May 6

Cord Blood News 2.17, May 6, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events

TOP STORY

Successful Engraftment After Reduced-Intensity Umbilical Cord Blood Transplantation for Myelofibrosis
Researchers describe 14 patients with primary (n = 1) and secondary myelofibrosis (n = 13) who underwent reduced-intensity umbilical cord blood transplantation. [Blood]


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SCIENCE NEWS

New Microscopy Technique Reveals Mechanics of Blood Cell Membranes
A team of researchers have developed a model that could lead to breakthroughs in screening and treatment of blood-cell-morphology diseases, such as malaria and sickle-cell disease. [Press release from University of Illinois discussing online prepublication in Proceedings of the National Academy of Sciences USA]


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CURRENT PUBLICATIONS

Measurement of Red Blood Cell Mechanics During Morphological Changes
Researchers apply a noncontact optical interferometric technique to quantify the thermal fluctuations of red blood cell membranes with 3 nm accuracy over a broad range of spatial and temporal frequencies. [Proc Natl Acad Sci U S A]


Donor Cell Leukemia in Umbilical Cord Blood Transplant Patients. A Case Study and Literature Review Highlighting the Importance of Molecular Engraftment Analysis
Investigators report a case of donor cell leukemia in a pediatric patient with a history of acute myeloid leukemia that manifested as recurrent AML FAB type M5 fourteen months after umbilical cord blood transplantation. [J Mol Diagn]


Human Umbilical Cord Blood Mesenchymal Stem Cell-Derived Extracellular Matrix Prohibits Metastatic Cancer Cell MDA-MB-231 Proliferation
Researchers demonstrated that the extracellular matrix produced by umbilical cord blood mesenchymal stem cells was able to arrest the growth of metastatic tumor cells by upregulating levels of PTEN in aggressive cancer cells. [Cancer Lett]


Paracrine Effect of Canine Allogenic Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Mixed with Beta-Tricalcium Phosphate on Bone Regeneration in Ectopic Implantations
The aim of this study was to evaluate the paracrine effects of canine umbilical cord blood mesenchymal stromal cells mixed with beta-tricalcium phosphate on bone regeneration in ectopic implantation. [Cytotherapy]


Human Umbilical Cord Blood Mononuclear Cell Transplantation in Rats with Intrinsic Sphincter Deficiency
To evaluate the effectiveness of the human umbilical cord blood (HUCB) transplantation for the treatment of intrinsic sphincter deficiency (ISD), researchers analyzed the short term effects of HUCB mononuclear cell transplantation in rats with induced-ISD. [J Korean Med Sci]


European Survey on Clinical Use of Cord Blood for Hematopoietic and Non-Hematopoietic Indications
This report describes the evolution of cord blood hematopoietic stem cell transplants in Europe over time and its current status. [Transfus Apher Sci


Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
In order to study the mechanisms by which migration of glioma cells can be inhibited by the upregulation of the PTEN gene, researchers studied two glioma cell lines (SNB19 and U251) and two glioma xenograft cell lines (4910 and 5310) alone and in co-culture with human umbilical cord blood-derived mesenchymal stem cells. [PLoS One]



INDUSTRY NEWS

Springfield-Based Blood Center to Merge with Center in Iowa
Springfield’s Central Illinois Community Blood Center plans to merge July 1 with a larger independent blood center that operates in Illinois, Iowa, Missouri and southwestern Wisconsin. [The State Journal-Register]


Iowa Blood Banks Finalize Merger
The Siouxland Community Blood Bank said recently it has completed its merger with the Blood Center of Iowa. [Sioux City Journal]


Details of New Wellcome Trust Investigator Awards Announced
The Wellcome Trust today announces further details of its Investigator Awards, a major new scheme to support world-class researchers to tackle ambitious research questions about health and disease. [Wellcome Trust Press Release]


Banner Hospital’s EMS First in State Approved to Transport Blood Products
The Nevada State Health Division Office of Emergency Medical Systems has approved Banner Churchill Community Hospital’s Emergency Medical Service as the first emergency medical system (EMS) in the state to transport patients with blood and blood products being administered while performing an interfacility transfer. [Lahontan Valley News]


Osiris Receives Milestone Payment for Prochymal Development Progress in Japan
Osiris Therapeutics, Inc. announced that it has achieved a $1 million milestone payment from its Japanese commercial partner, JCR Pharmaceuticals, for development progress made advancing Prochymal for the treatment of acute graft vs. host disease in Japan. [Osiris Therapeutics, Inc. Press Release]



POLICY NEWS

Blood Bank Bill Dies in Tallahassee
The bill that would have forced Florida blood banks to open their financial books to the public was declared dead by its sponsor in the state Senate. [Florida Senate, United States]

CIRM Awards $28 Million to Answer Fundamental Questions in Stem Cell Biology
At a meeting at the City of Hope, the governing board of the California Institute for Regenerative Medicine (CIRM), the state stem cell agency created by Proposition 71, approved funding $28 million to support 16 Basic Biology II Awards that answer fundamental questions about stem cell biology and one Leadership Award. [California Institute for Regenerative Medicine, United States]


Commission to Boost Research and Innovation by Making it Easier to Apply for and Manage European Union Grants
The European Commission has unveiled a plan to simplify the procedures for taking part in European Union-funded research projects. [European Research, Innovation and Science Commission, European Union]


$11.5 Million for Stem Cell Therapy Research
Ontario’s provincial government has announced $11.5 million in funding support for researchers at McMaster University, who are developing stem cell-based therapies. [Global Leadership Round in Genomics & Life Sciences, Canada]


Final Opportunity to Attend a 2010 NIH Regional Seminar on Program Funding & Grants Administration: Register Now for Portland, OR (June 24-25, 2010) (NOT-OD-10-092) [National Institutes of Health, United States]


Frequently Asked Questions (FAQ) for: Centers of Research Translation (CORT) (P50) RFA-AR-11-002 (NOT-AR-10-035) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) (PA-10-178) [National Institutes of Health, United States]


Extension of Expiration Date for PA-07-277, PA-06-367, and PA-06-368: Research on Ethical Issues in Human Subjects Research (NOT-OD-10-086) [National Institutes of Health, United States]


List of Establishments Granted Approval for a Variance to 21CFR640.3(d) and 21CFR640.3(f) [Center for Biologics Evaluation and Research, United States]


May 7, 2010: Vaccines and Related Biological Products Advisory Committee Meeting Announcement [Center for Biologics Evaluation and Research, United States]


FDA Approves Chagas Disease Screening Test for Blood, Tissue and Organ Donors
The U.S. Food and Drug Administration approved a second test to screen blood, tissue and organ donors for a blood-borne parasite, Trypanosoma cruzi that causes Chagas disease, a serious and potentially fatal parasitic infection. [Food and Drug Administration, United States]


Considerations Regarding Food and Drug Administration Review and Regulation of Articles for the Treatment of Rare Diseases; Public Hearing [Docket No. FDA-2010-N-0218] [Food and Drug Administration, United States]


Guidance for Industry: Requalification Method for Reentry of Blood Donors Deferred Because of Reactive Test Results for Antibody to Hepatitis B Core Antigen (Anti-HBc); Availability [Docket No. FDA-2008-D-0263] [Food and Drug Administration, United States]


Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation Safety and Quantitative Risk Assessment: Blood Safety and Availability; Public Workshops [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]



EVENTS

XXIII International Symposium on Technological Innovations in Laboratory Hematology
May 10-12, 2010
Brighton, United Kingdom


16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States 


8th Annual International Umbilical Cord Blood Transplantation Symposium
June 3-5, 2010
San Francisco, United States


International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States


Select Biosciences World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland


International Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

American Association of Blood Banks (AABB) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States


52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States


Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


 

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