Volume 2.18 | May 13

Cord Blood News 2.18, May 13, 2010
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events


In Vitro Differentiation of Unrestricted Somatic Stem Cells into Functional Hepatic-Like Cells Displaying a Hepatocyte-Like Glucose Metabolism
The results of the present study indicate that unrestricted somatic stem cells derived from human umbilical cord blood represent a stem cell source with a substantial hepatic differentiation capacity which hold the potential for clinical applications. [J Cell Physiol]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) 

In Vitro and In Vivo Analysis of Endothelial Progenitor Cells from Cryopreserved Umbilical Cord Blood: Are We Ready for Clinical Application?
Researchers compared the expansion, functional features, senescence pattern over culture and in vivo angiogenic potential of circulating endothelial progenitor cells isolated from fresh or cryopreserved cord blood. [Cell Transplant]

Good Manufacturing Practice-Grade Production of Unrestricted Somatic Stem Cell from Fresh Cord Blood
Together with implemented in-process controls guaranteeing contamination-free products with adult stem cell character, unrestricted somatic stem cells produced as suggested here may serve as a universal allogeneic stem cell source for future cell treatment and clinical settings. [Cytotherapy]

No Contribution of Umbilical Cord Mesenchymal Stromal Cells to Capillarization and Venularization of Hepatic Sinusoids Accompanied by Hepatic Differentiation in Carbon Tetrachloride-Induced Mouse Liver Fibrosis
Human umbilical cord mesenchymal stromal cells can differentiate into hepatocyte-like cells but do not accelerate the capillarization and venularization of hepatic sinusoids, finally leading to the partial improvement of liver function in mice with CCl4-mediated chronic liver fibrosis. [Cytotherapy]

Engraftment of Unrelated Cord Blood After Reduced-Intensity Conditioning Regimen in Children with Refractory Neuroblastoma: A Feasibility Trial
Researchers undertook a pilot trial of unrelated cord blood transplantation after reduced intensity conditioning regimen in children with relapsed neuroblastoma to assess engraftment and tolerability in this heavily pretreated population. [Bone Marrow Transplant]

Factors Affecting Mortality Following Myeloablative Cord Blood Transplantation in Adults: A Pooled Analysis of Three International Registries
A retrospective analysis was conducted to examine factors affecting early mortality after myeloablative, single-unit cord blood transplantation for hematological malignancies in adolescents and adults. [Bone Marrow Transplant]

Induction of Apoptosis in Glioma Cells Requires Cell-to-Cell Contact with Human Umbilical Cord Blood Stem Cells
Researchers used human umbilical cord blood (hUCB) enriched in CD44 and CD133 cells for their studies and observed that glioma cells co-cultured with hUCB undergo apoptosis. [Int J Oncol]

Multiple Unrelated Chromosomal Abnormalities in Host Cells After Cord Blood Transplantation
Researchers experienced a 16-year-old patient with T-cell acute lymphoblastic leukemia, who had multiple unrelated chromosomal abnormalities in host cells after chemotherapy and cord blood transplantation. [J Pediatr Hematol Oncol]

The Effect of IL-28A on Human Cord Blood CD4+ T cells
Researchers showed that IL-28A is not involved in expression of CD25 and Foxp3 markers and proliferation of CD4+CD25- T cells, and that these findings also suggest that induction of Foxp3 in T cells activated by anti-CD3/anti-CD28 does not result in the regulatory activity in these cells. [Immunopharmacol Immunotoxicol]


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Mesoblast to Acquire Angioblast Systems Inc.
Australia’s regenerative medicine company, Mesoblast Limited, announced that it will acquire its United States associate company, Angioblast Systems, Inc. (Angioblast). [Mesoblast Limited Press Release]

Beike Biotechnology Opens World’s Largest Stem Cell Storage and Processing Facility
Beike Biotechnology Co. Ltd. and the Jiangsu government’s China Medical City opened China’s state-of-the-art stem cell storage and processing facility. [Beike Biotechnology Co. Ltd. Press Release]

PacifiCord Earns AABB Accreditation
Dedicated to serving the family cord blood banking needs of Southern California, PacifiCord announced that the company has met the rigorous requirements set by AABB and has earned accreditation. [BioMed Reports Press Release]

CORD:USE, a Leader in the Cord Blood Banking Field, to Offer Its Prestigious Services to New Parents
CORD:USE Cord Blood Bank is pleased to announce its plans to open the CORD:USE Family Cord Blood Bank. [CORD:USE Press Release]


NSF to Ask Every Grant Applicant for Data Management Plan
Scientists seeking funding from the National Science Foundation (NSF) will soon need to spell out how they plan to manage the data they hope to collect. It’s part of a broader move by NSF and other federal agencies to emphasize the importance of community access to data. [National Science Foundation, United States]

Montgomery Council Gives the Go-Ahead to ‘Science City’ Plan
County officials hope the development, which could be two decades in the making, could position Montgomery as an international center for biosciences that would rival North Carolina’s Research Triangle or Palo Alto, Calif. The county is home to almost 300 biotech companies and institutions. [Montgomery County Council, United States]

Granholm Announces Stem Cell Public Education Day
Governor Jennifer M. Granholm announced at a press conference in Chicago that the World Stem Cell Summit will kick off with a free “Public Education Day” on October 3 at the Detroit Science Center. [Michigan, United States]

With Hung Parliament, British Scientists Wonder Who’s the Boss?
On May 7, 2010, Britain woke up to an uncertain political future-and British scientists continue to remain in the dark about how expected government funding cuts will slice into research efforts. [Parliament of the United Kingdom, United Kingdom]

Training Australian Scientists in Latest Stem Cell Discoveries
For the first time in Australia, young researchers will be trained in the techniques of growing and using human induced pluripotent stem cells in research. [Australian Stem Cell Centre, Australia]

Notice of Funding Opportunity for a Cell Characterization Core for the National Heart, Lung and Blood Institute Progenitor Cell Biology Consortium (NOT-HL-10-109) [National Institutes of Health, United States]

Notice of Intent to Publish Request for Applications for the Blood and Marrow Transplant Clinical Trials Network Data Coordinating Center (U10) (NOT-HL-10-108) [National Institutes of Health, United States]

Enhancing Peer Review: Expectation for Service on NIH Peer Review and Advisory Groups (NOT-OD-10-089) [National Institutes of Health, United States]

Drug Safety and Risk Management Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of Patient Information Prototypes [Docket No. FDA-2010-N-0184] [Food and Drug Administration, United States]


16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States 

Stem Cell Investor & Executive Networking Conference Event (S.C.I.E.N.C.E.)
June 1, 2010
New York, United States

8th Annual International Umbilical Cord Blood Transplantation Symposium
June 3-5, 2010
San Francisco, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

Select Biosciences World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

International Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

AABB (formerly known as the American Association of Blood Banks) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



Business Development Manager Europe – Cell Therapy Products (Pall Corporation)

Manager/Sr. Manager, Therapeutic Cell Solutions, Process Development (Lonza)

Sr. Product Support and Training Specialist (CardianBCT)

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