Volume 2.30 | Aug 12

Cord Blood News 2.30, August 12, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events


Successful Engraftment After Reduced-Intensity Umbilical Cord Blood Transplantation for Myelofibrosis 
The use of umbilical cord blood could be feasible even for patients with severe marrow fibrosis, from the viewpoint of donor cell engraftment. [Blood]



Taiwanese Researchers Find Breakthrough in Stem Cell Study
Scientists at the National Health Research Institutes announced a breakthrough in stem cell research through experiments that successfully turn cells in the umbilical vein into “all-purpose” induced pluripotent stem cells. [The China Post]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

CCR7 Impairs Hematopoiesis Following Hematopoietic Stem Cell Transplantation Increasing Susceptibility to Invasive Aspergillosis
Researchers investigated the role of CCR7 in a murine model of invasive aspergillosis following combined hematopoietic stem cell and myeloid progenitor cell transplantation into lethally irradiated wild-type mice. [Blood]

Combination of Injectable Multiple Growth Factor-Releasing Scaffolds and Cell Therapy as an Advanced Modality to Enhance Tissue Neovascularization
Vasculogenic progenitor cell therapy is significantly enhanced by in vivo tissue engineering providing a proangiogenic and provasculogenic growth factor-enriched microenvironment. Therefore, combined use of scaffold-released growth factors and cell therapy improves neovascularization in ischemic diseases and may translate into more pronounced clinical effects. [Arterioscler Thromb Vasc Biol]

Regulatory T Cell Content in the Bone Marrow Graft Does not Predict the Occurrence of Acute GVHD
Researchers report that the regulatory T cell content of allogeneic bone marrow transplantation did not predict the occurrence of acute graft versus host disease (GVHD). [Biol Blood Marrow Transplant]

Individualized Intervention Guided by BCR-ABL Transcript Levels After HLA-Identical Sibling Donor Transplantation Improves HSCT Outcomes for Patients with Chronic Myeloid Leukemia
Individualized intervention based on the post-hematopoietic stem cell transplantation (HSCT) BCR-ABL transcript level can decrease relapse and increase leukemia-free survival of patients with chronic myeloid leukemia after HLA-identical sibling HSCT. [Biol Blood Marrow Transplant]

Double Umbilical Cord Blood Transplantation with Reduced Intensity Conditioning and Sirolimus-Based GVHD Prophylaxis
Sirolimus and tacrolimus provide excellent graft versus host disease (GVHD) prophylaxis in double umbilical cord blood transplantation (DUCBT), and this regimen is associated with low non-relapse mortality after DUCBT. [Bone Marrow Transplant]

Successful Tandem (Autologous-Cord Blood) SCT in Advanced Neuroblastomas with Highly Amplified MYCN
In an attempt to induce the graft-versus-tumor effect, researchers performed autologous peripheral blood stem cell transplantation (SCT) followed by allogeneic cord blood transplantation in three consecutive advanced neuroblastoma cases with marked bone marrow infiltration and high MYCN amplification. [Bone Marrow Transplant]

Optimal Timing of G-CSF Administration for Effective Autologous Stem Cell Collection
The present study showed that granulocyte colony-stimulating factor (G-CSF) injection three hours before apheresis improved the efficacy of autologous stem cell collection. [Bone Marrow Transplant]


Cord Blood America Signs DNA Testing Deal; Offers Families Predetermination Testing Services
Cord Blood America, Inc. announced that within 90 days it will begin selling DNA Predisposition testing services in conjunction with The DNA Shop, LLC, Henderson, Nevada. [Cord Blood America, Inc. Press Release]

FDA Grants Fenwal New 510(K) Clearance
Fenwal Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Fenwal a new 510(k) clearance for its Amicus® blood cell separator. [Fenwal Inc. Press Release]

Panel Recommends Defining Select Agents by DNA Sequence
The way to bring synthetically designed genomes that could be potentially as deadly as known pathogens under regulation, according to a new National Academies report, is to develop a new system of defining select agents based on DNA sequences. [ScienceInsider]

Free Access to U.S. Research Papers Could Yield $1 Billion in Benefits
A new economic analysis finds that making taxpayer-funded scientific papers freely available would yield more than $1 billion in benefits to the U.S. economy over 30 years–five times the costs of archiving the papers. [ScienceInsider]


House Bill Reauthorizes National Marrow Donor Registry
Representatives introduced legislation that would reauthorize the national registry for people looking for a marrow donor or umbilical cord blood unit. The Senate recently introduced sister legislation. [House of Representatives, United States]

Decision Memo for Allogeneic Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome (CAG-00415N)
The Centers for Medicare and Medicaid Services have determined that the evidence does not demonstrate that the use of allogeneic hematopoietic stem cell transplantation improves health outcomes in Medicare beneficiaries with myelodysplastic syndrome. [Centers for Medicare and Medicaid Services, United States]

Scientists Decry Proposed Ban on Chimp Research
In the latest twist in the protracted debate over the use of chimpanzees in biomedical research, U.S. senators introduced the Great Ape Protection Act, an identical bill to one that has been stuck in a House of Representatives committee for more than a year. [Senate, United States]

Senate Bill Would Encourage Drugs Targeting Rare Kids’ Diseases
A group of bipartisan senators introduced legislation to entice drug makers to focus more intently on cures for uncommon children’s diseases. [Senate, United States]

EU Agency Allows Access to Drug Side Effects Data
The European Medicines Agency has agreed to provide access to studies about drug side effects, following criticism over data secrecy from the European Ombudsman. [European Medicines Agency, European Union]

Blood and Marrow Transplant Clinical Trials Network (BMT CTN)-Data Coordinating Center (U10) (RFA-HL-11-028) [National Institutes of Health, United States]

Blood and Marrow Transplant Clinical Trials Network (BMT CTN)-Core Clinical Centers (U10) (RFA-HL-11-013) [National Institutes of Health, United States]

National Heart, Lung, and Blood Institute; Notice of Closed Meetings (FR Doc. 2010-19933) [National Institutes of Health, United States]

Technical Assistance Videocast for RFA-RR-10-007: Clinical and Translational Science Coordinating Center (U54) (NOT-RR-10-012) [National Institutes of Health, United States]

NIH Common Fund Transformative Research Projects Program (R01) (RFA-RM-10-010) [National Institutes of Health, United States]

Chimpanzee Biomedical Research Program Limited Competition (U42) (RFA-RR-10-008) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-19939) [National Institutes of Health, United States]

Center for Scientific Review, Notice of Closed Meetings (FR Doc. 2010-19938) [National Institutes of Health, United States]
2010 Biological License Application Supplement Noteworthy Approvals [Center for Biologics Evaluation and Research, United States]
Memorandum of Understanding Between United States Food and Drug Administration and the Centers for Medicare and Medicaid Services [Docket No. FDA-2010-N-0004] [Food and Drug Administration, United States]

Agency Information Collection Activities; Proposed Collection; Comment Request; Generic Food and Drug Administration Rapid Response Surveys [Docket No. FDA-2010-N-0380] [Food and Drug Administration, United States]

Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Administrative Procedures for the Clinical Laboratory Improvement Amendments of 1988 Categorization [Docket No. FDA-2010-N-0199] [Food and Drug Administration, United States]

EVENTS (Listed by Date)

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

International Society for Cellular Therapy – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

International Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
September 24-27, 2010
Montpellier, France

International Society for Cell and Gene Therapy of Cancer (ISCGT) Congress
September 27-29, 2010
Doha, Qatar

5th Annual Meeting of the German Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

AABB (formerly known as the American Association of Blood Banks) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States

Institute for Genomic Medicine Inaugural Symposium
October 11-12, 2010
San Diego, United States

5th Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York City, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

World Cord Blood Congress
November 4-7, 2010
Marseille, France

Cambridge Healthtech Institute’s Inaugural Stem Cells in Drug Discovery and Development
November 8-9, 2010
San Diego, United States

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

Stem Cell Network’s 10th Annual Scientific Meeting
November, 22-24, 2010
Calgary, Alberta

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Cell Therapy Technologist (Opexa Therapeutics)

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