Volume 2.32 | Aug 26

Cord Blood News 2.32, August 26, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events


TOP STORY

Transplantation of Insulin Producing Cells Derived from Umbilical Cord Stromal Mesenchymal Stem Cells to Treat NOD Mice 
Researchers demonstrated that differentiated insulin-producing cells from human umbilical cord stromal mesenchymal stem cells transplanted into nonobese diabetic (NOD) mice could alleviate hyperglycemia in diabetic mice. [Cell Transplant]

MethoCult® Express Video  
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SPECIAL FEATURE


Complimentary Webinar Presented by STEMCELL Technologies: EPO and Erythropoiesis, Detecting Lineage Commitment



SCIENCE NEWS

Human Umbilical Cord Blood Cells Aid Lab Animal Brain Cell Survival After Simulated Stroke
Human umbilical cord blood cells used to treat cultured rat brain cells deprived of oxygen appear to protect astrocytes from cell death after stroke-like damage. [Press release from EurekAlert! discussing online prepublication in Stem Cell Reviews and Reports]

TeSR™2  
Animal Protein-Free
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by STEMCELL Technologies
 
 
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

TIMP-3 Recruits Quiescent Hematopoietic Stem Cells into Active Cell Cycle and Expands Multipotent Progenitor Pool
Researchers show that tissue inhibitor of metalloproteinase-3 (TIMP-3), an endogenous regulator of metalloproteinases, stimulates hematopoietic stem cell (HSC) proliferation by recruiting quiescent HSCs into the cell cycle. [Blood]

Pre-Transplant Functional Imaging Predicts Outcome Following Autologous Stem Cell Transplant for Relapsed and Refractory Hodgkin Lymphoma
Studies evaluating novel salvage therapies, conditioning regimens, post-autologous stem cell transplant (ASCT) maintenance, or allogeneic stem cell transplant are warranted for patients who fail to normalize pre-ASCT functional imaging. [Blood]
 
The Effect of Human Umbilical Cord Blood Cells on Survival and Cytokine Production by Post-Ischemic Astrocytes in Vitro
Data demonstrate that the tested cord blood fractions do not enhance astrocyte survival when delivered individually, suggesting there is either another cellular component that is neuroprotective or an interaction of all the cells is essential for protection. [Stem Cell Rev]

Availability of Cord Blood Extends Allogeneic Hematopoietic Stem Cell Transplant Access to Racial and Ethnic Minorities
Researchers prospectively evaluated availability of unrelated donors and cord blood according to patient ancestry in 553 patients without suitable sibling donors. [Biol Blood Marrow Transplant]

Fludarabine Based Conditioning Chemotherapy for Allogeneic Hematopoietic Stem Cell Transplantation in Acquired Severe Aplastic Anemia
The Fludarabine-based conditioning regimen used in this study with relatively young cohort of patients was well tolerated with low rate of rejection and treatment outcomes comparable to other more intense and potentially more toxic conditioning regimens. [Biol Blood Marrow Transplant]

Characterization of Long-Term Mixed Donor-Donor Chimerism After Double Cord Blood Transplantation
Results suggest that the two stable cord blood units are different phenotypically and functionally: one unit shows more naive T cells, lower T cell cytokine production and higher frequencies of natural killer cells, the other shows higher frequencies of well-differentiated and functional lymphocytes. [Clin Exp Immunol]

Prognostic Value of Comorbidity for Auto-SCT Eligibility and Outcome in Relapsed or Refractory Aggressive Non-Hodgkin’s Lymphoma
In patients with relapsed non-Hodgkin’s lymphoma, comorbidity at relapse is associated with receipt of autologous stem cell transplantation (auto-SCT) and subsequent survival independently from the secondary age-adjusted International Prognostic Index. [Bone Marrow Transplant]

Perspectives of Potential Donors on Cord Blood and Cord Blood Cryopreservation: A Survey of Highly Educated, Pregnant Korean Women Receiving Active Prenatal Care
A considerable portion of educated pregnant Korean women has more than minimal knowledge of cord blood (CB), but the levels of knowledge regarding the potency of the public bank and the current usefulness and limitations of CB are generally low; in addition, obstetricians play insignificant roles in disseminating knowledge. [Transfusion]

INDUSTRY NEWS

Cerus Signs Agreement to Acquire INTERCEPT Blood System Asian Commercial Rights from BioOne
Cerus Corporation announced that it has signed an agreement to acquire BioOne Corporation’s commercialization rights for the INTERCEPT Blood System for platelets and plasma, subject to approval of the transaction by BioOne’s shareholders. [Cerus Corporation Press Release]

Cryo-Cell Announces Progress with Strategic Partner S-Evans Biosciences, Inc.
Cryo-Cell International, Inc. announced that S-Evans Biosciences, the Company’s exclusive Célle menstrual stem cell technology license partner in China has opened a new state-of-the-art laboratory operation and research and development facility located in a Hi-Tech park designated to become an epicenter for stem cell and genomics R&D; cellular therapies and stem cell cryopreservation services. [Cryo-Cell International, Inc. Press Release]

Life Technologies Announces Agreement to Acquire Ion Torrent
Life Technologies Corporation announced a definitive agreement to acquire Ion Torrent for $375 million in cash and stock. [Life Technologies Corporation Press Release]

Stem Cell Agency Commits $243 Million, Expands Team Approach to Developing New Therapies
The Governing Board of the California Institute for Regenerative Medicine approved the concept for up to $243 million round of funding to move stem cell-based therapies to clinical trial. [California Institute for Regenerative Medicine Press Release]

Soligenix Announces Award of $1.2 Million FDA Orphan Products Development Grant
Soligenix, Inc. announced that it has been awarded a three year $1.2 million clinical research grant by the Office of Orphan Products Development of the U.S. Food and Drug Administration (FDA) pursuant to its Orphan Products Development Program. [Press Release]

Celgene Expects to Receive a Paragraph IV Notification of an ANDA Filing for REVLIMID®
Celgene Corporation announced that information was posted on the FDA web site indicating that an Abbreviated New Drug Application (ANDA) has been received by the Office of Generic Drugs containing a “Paragraph IV” patent certification, for REVLIMID (lenalidomide) 25 mg capsules. [Celgene Corporation Press Release]

POLICY NEWS

Federal Judge: Obama Stem Cell Policy Halted
Research on embryonic stem cells funded by the U.S. government must stop immediately for a court-ordered review, Judge Royce Lamberth of the U.S. District Court for the District of Columbia ruled. [United States District Court for the District of Columbia]

NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants
National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States]

Universities, Scientists Urge NIH to Narrow Conflicts Rule
The biomedical research community is reacting with concern to a proposal from the National Institutes of Health (NIH) to clamp down on financial conflicts of interest in research. [National Institutes of Health, United States]

Lawrence A. Tabak Named Principal Deputy Director NIH
National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced the appointment of Lawrence A. Tabak, D.D.S., Ph.D., as principal deputy director of the National Institutes of Health. [National Institutes of Health, United States]
 
Proposed Collection; Comment Request; STAR METRICS–Science and Technology in America’s Reinvestment: Measuring the Effects of Research on Innovation, Competitiveness and Science (FR Doc. 2010-20614) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-20588) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20675) [National Institutes of Health, United States]
 
Support of National Institute of General Medical Sciences Program Project Grants (P01) (PAR-10-266) [National Institutes of Health, United States]
 
Submission for Office of Management and Budget Review; Comment Request; Resource for the Collection and Evaluation of Human Tissues and Cells from Donors With an Epidemiology Profile (NCI) (FR Doc. 2010-21098) [National Institutes of Health, United States]
 
National Heart, Lung, and Blood Institute; Notice of Closed Meeting (FR Doc. 2010-20857) [National Institutes of Health, United States]
 
Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

EVENTS (Listed by Date)

International Society for Cellular Therapy – Europe 2nd Regional Meeting

September 11-14, 2010
Belgirate, Italy

Stem Cells USA & Regenerative Medicine Congress 2010

September 13-15, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

International Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

Cellular Therapy of Cancer Symposium – ATTACK Project Meeting

September 24-27, 2010
Montpellier, France

International Society for Cell and Gene Therapy of Cancer (ISCGT) Congress
September 27-29, 2010
Doha, Qatar

5th Annual Meeting of the German Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

AABB (formerly known as the American Association of Blood Banks) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States

Institute for Genomic Medicine Inaugural Symposium

October 11-12, 2010
San Diego, United States

5th Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York City, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

BioMalaysia 2010 Conference and Exhibition
November 2-4, 2010
Kuala Lumpur, Malaysia

World Cord Blood Congress
November 4-7, 2010
Marseille, France

Cambridge Healthtech Institute’s Inaugural Stem Cells in Drug Discovery and Development
November 8-9, 2010
San Diego, United States

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

Stem Cell Network’s 10th Annual Scientific Meeting
November, 22-24, 2010
Calgary, Alberta

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Select Biosciences 5th Annual Stem Cells World Congress

January 24-25, 2011
San Diego, United States

Visit
our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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