Volume 2.39 | Oct 14

Cord Blood News 2.39, October 14, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events

TOP STORY

Reduced Methyl-CpG Protein Binding Contributing to miR-184 Expression in Umbilical Cord Blood CD4(+) T Cells
Numerous studies confirm blunted allogeneic responses by umbilical cord blood graft CD4+ T cells. This may be attributable in part to dramatically reduced NFAT1 protein without corresponding mRNA discrepancies. [Leukemia]

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SCIENCE NEWS

Research Shows a Promising New Method to Reduce Graft-Versus-Host-Disease After Bone Marrow Transplantation
Researchers have discovered a new method to prevent the immune-system attacks that often occur following bone marrow transplants. [Press release from the University of Michigan discussing online prepublication in Blood]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Notch Signaling Is a Critical Regulator of Allogeneic CD4+ T Cell Responses Mediating Graft-Versus-Host Disease
Results identify Notch as a novel essential regulator of pathogenic CD4+ T cell responses during acute graft-versus-host disease and suggest that Notch signaling in T cells should be investigated as a therapeutic target following allogeneic hematopoietic stem cell transplantation. [Blood]

Irradiation Enhances the Tumor Tropism and Therapeutic Potential of TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Glioma Therapy
Researchers show that tumor irradiation enhances the tumor tropism of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) and the therapeutic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) delivered by UCB-MSCs. [Stem Cells]

Human Umbilical Cord Blood Derived Mesenchymal Stem Cells Upregulate Myelin Basic Protein in Shiverer Mice
Researchers aimed to investigate the potential of human umbilical cord blood-derived pluripotent mesenchymal stem cells to myelinate the axons of shiverer mice brains. [Stem Cells Dev]

Rituximab Treatment for Epstein Bar Virus (EBV) DNA-Emia, After Alternative Donor Transplants
The study confirms the effectiveness of rituximab in controlling EBV DNA-emia in allogeneic hemopoietic stem cell transplant; patients with increasing EBV copies despite rituximab, are at high risk of EBV post-transplant lymphoproliferative disorder and may be considered for alternative therapies. [Biol Blood Marrow Transplant]

Fatal Intracranial Hemorrhage Following Administration of Recombinant Thrombomodulin in a Patient After Cord Blood Transplantation
Sinusoidal obstruction syndrome (SOS) is a fatal complication after hematopoietic stem cell transplantation. Although the etiology of SOS remains to be fully elucidated, previous studies suggested that preparative regimens cause damage to the sinusoidal endothelial cells leading to a hypercoagulable state and exaggerated cytokine production. [Bone Marrow Transplant]

Unrelated Umbilical Cord Blood Transplant for Juvenile Metachromatic Leukodystrophy: A Five-Year Follow-Up in Three Affected Siblings
Unrelated umbilical cord blood transplantation was used to treat three siblings with juvenile metachromatic leukodystrophy. The efficacy of this therapy was measured over a five-year period with serial neurological exams, neuroimaging, nerve conduction studies, and neuropsychological evaluations. [Mol Genet Metab]

CTD Small Phosphatase Like 2 Can Increase Epsilon- and Gamma-Globin Gene Expression in K562 Cells and CD34+ Cells Derived from Umbilical Cord Blood
Researchers aimed to identify trans-activators of epsilon- and gamma-globin expression and provide new candidate targets for effective treatment of sickle cell disease and beta-thalassemia through activation of epsilon- and gamma-globin genes in adults. [BMC Cell Biol]

Immunohistochemical and Transcriptional Expression of Matrix Metalloproteinases in Full-Term Human Umbilical Cord and Human Umbilical Vein Endothelial Cells
Researchers investigated the expression of matrix metalloproteinases (MMPs) in human umbilical cord and human umbilical vein endothelial cells though immunohistochemistry, RT-PCR and gelatin zymography. [J Mol Histol]


INDUSTRY NEWS

American Cancer Society Awards New Research and Training Grants
The American Cancer Society has awarded 94 national research and training grants totaling $46,633,000 to 70 institutions nationwide in the first of two grants cycles for 2011. [American Cancer Society Press Release]

BrainStorm Receives Approval to Begin Clinical Trial of Adult Stem Cell Therapy in Patients with ALS
BrainStorm Cell Therapeutics Inc. announced that the Israeli Ministry of Health has granted clearance for a Phase I/II clinical trial using the company’s autologous NurOwn™ stem cell therapy in patients with amyotrophic lateral sclerosis (ALS). [BrainStorm Cell Therapeutics Inc. Press Release]

Mesoblast Targets Broader Cancer Indications for Bone Marrow Transplant Product
Australian regenerative medicine company Mesoblast Limited announced that it is broadening the oncology applications of its “off-the-shelf” cell product for expansion of hematopoietic stem cells in patients with blood cancers. [Mesoblast Limited Press Release]
 
Mercy Starts First Public Umbilical Cord Blood Program
Mercy Medical Center announced the state’s first public program allowing parents to donate and bank the stem cells from their newborns’ umbilical cords. [The Baltimore Sun]

Cryo-Cell International, Inc. Reports Third Quarter 2010 Results
Cryo-Cell International, Inc. announced results for the third quarter ended August 31, 2010. [Cryo-Cell International, Inc. Press Release]

POLICY NEWS

FDA’s $25 Million Pitch for Improving Drug Regulation
The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science” — research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States]

IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials
If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany]

Advisory Council on Blood Stem Cell Transplantation; Notice of Meeting (FR Doc. 2010-25646) [Department of Health and Human Services, United States]

Draft Guidance for Industry: Early Clinical Trials With Live Biotherapeutic Products: Chemistry, Manufacturing, and Control Information; Availability (FR Doc. 2010-25850) [Food and Drug Administration, United States]
 
Draft Guidance for Industry on Investigational New Drug Applications–Determining Whether Human Research Studies Can Be Conducted Without an Investigational New Drug Application; Availability (FR Doc. 2010-25851) [Food and Drug Administration, United States]
 
Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States]
 
Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational Science Awards (CTSA) Initiative (FR Doc. 2010-25589) [Department of Health and Human Services, United States]
 
Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-25587) [Department of Health and Human Services, United States]
 
National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-25634) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25595) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25597) [National Institutes of Health, United States]
 
Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25598) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25601) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-25636) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-25640) [National Institutes of Health, United States]

EVENTS (Listed by Date)

National Marrow Donor Program (NMDP) 2010 Council Meeting
October 15-17, 2010
Minneapolis, United States

‘HAA 2010’ – The Combined Annual Scientific Meeting of HSANZ, ANZSBT AND ASTH
October 17-20, 2010
Auckland, New Zealand

Stem Cells and Regenerative Medicine – New Solutions to Old Problems
October 18-20, 2010
San Antonio, United States

International Consensus Conference: Risk-Based Decision Making for Blood Safety
October 26-28, 2010
Toronto, Canada

2nd Annual Stem Cells Asia and Regenerative Medicine Congress
October 26-28, 2010
Seoul, Korea

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010
Singapore

NEW 2010 National GvHD Symposium
November 4, 2010
Cleveland, United States

World Cord Blood Congress
November 4-7, 2010
Marseille, France

Cambridge Healthtech Institute’s Inaugural Stem Cells in Drug Discovery and Development
November 8-9, 2010
San Diego, United States

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Hematopoiesis
March 27-April 1, 2011
Big Sky, United States

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States


Visit
our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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