Volume 2.41 | Oct 28

Cord Blood News 2.41, October 28, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events

TOP STORY

Human Multipotent Mesenchymal Stromal Cells from Distinct Sources Show Different In Vivo Potential to Differentiate into Muscle Cells When Injected in Dystrophic Mice 
Researchers evaluated if mesenchymal stromal cells from two different sources, umbilical cord tissue and adipose tissue, have the same potential to reach and differentiate in muscle cells in vivo or if this capability is influenced by the niche from where they were obtained. [Stem Cell Rev]

PluripotentWallchart_645x110

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Infusion of HLA-Mismatched Peripheral Blood Stem Cells Improves Outcome of Chemotherapy for Acute Myeloid Leukemia in Elderly Patients
Results indicate that granulocyte colony-stimulating factor-mobilized donor peripheral blood stem cells in combination with conventional chemotherapy may provide a promising treatment modality for acute myeloid leukemia in elderly patients. [Blood]

Functional Recovery in Acute Traumatic Spinal Cord Injury After Transplantation of Human Umbilical Cord Mesenchymal Stem Cells
Treatment with human umbilical cord mesenchymal stem cells can facilitate functional recovery after traumatic spinal cord injury and may prove to be a useful therapeutic strategy to repair the injured spinal cord. [Crit Care Med]
 
Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma
Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for STRO1, OCT3/4 and SSEA-4 as well as the classic MSC-markers CD44, CD73, CD90, Ki67, CD105 and CD106 and negative for CD34 and CD45. [Stem Cells Dev]
 
Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication
Dermal papilla like tissues (DPLTs) have the same hair bulb structure inductive ability as natural DPLTs in vitro. Transplanted DPLTs can induce new hair follicle in athymic mice. As a result, umbilical cord-mesenchymal stem cells (MSCs) and bone marrow-MSCs may be an applicable and novel cell source for the generation of human hair cell therapy. [J Dermatol Sci]
 
Optimization and Scale-Up of Wharton’s Jelly-Derived Mesenchymal Stem Cells for Clinical Applications
In this study researchers attempted rapid clinical-scale expansion of Wharton’s jelly-derived mesenchymal stem cells which would allow these fetus-derived stem cells to be used for various allogeneic cell-based transplantations and tissue engineering. [Stem Cell Res]

The Conundrum of HLA-DRB1*14:01/*14:54 and HLA-DRB3*02:01/*02:02 Mismatches in Unrelated Hematopoietic Stem Cell Transplantation
Findings suggest that disparities at exon 3 of the HLA-DRB1 gene seem unlikely to influence the outcome after hematopoietic stem cell transplantation (HSCT). The same may be envisaged for HLA-DRB3*02:01 and *02:02 alleles which, although differing in the Ag binding site, seem unable to modulate an appreciable immune response in an HSCT setting. [Bone Marrow Transplant]
 
Carbohydrate-Mediated Inhibition of Ice Recrystallization in Cryopreserved Human Umbilical Cord Blood
Results suggest that carbohydrates with potent ice recrystallization inhibition (IRI) increase the yield of non-apoptotic and functional hematopoietic progenitors and provide a foundation for the development of novel synthetic carbohydrates with enhanced IRI properties to improve cryopreservation of umbilical cord blood. [Carbohydr Res]

CXCL8 Enhances the Angiogenic Activity of Umbilical Cord Blood-Derived Outgrowth Endothelial Cells In Vitro
Results demonstrate that CXCL8 stimulates the angiogenic activity of umbilical cord blood-derived outgrowth endothelial cells in vitro. [Cell Biol Int]

MethoCult® Express Video  
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INDUSTRY NEWS

Cellectis and the Center for iPS Cells Research and Application Enter Collaboration
Cellectis and the Center for iPS Cells Research and Application (CiRA) of Kyoto University have announced that they have started a scientific collaboration to combine Cellectis’ genome engineering technologies with CiRA’s induced pluripotent stem cell (iPS) technology to improve the natural characteristics of iPS cells for use as cellular tools. [Cellectis Press Release]
 
Cryo-Cell Announces Industry-Exclusive Agreement with MedTech For Solutions, Inc. Group Purchasing Organization
Cryo-Cell International, Inc. announced at the annual meeting of the American Society of Reproductive Medicine that the Company has formalized an industry-exclusive agreement with MedTech For Solutions, Inc., a Group Purchasing Organization representing a member network of 115 practices specializing in reproductive medicine, which operates, in conjunction with The Broadlane Group. [Cryo-Cell International, Inc. Press Release]
 
Karmanos Cancer Institute’s J.P. McCarthy Cord Stem Cell Bank Receives $1.4 Million Federal Contract
The J.P. McCarthy Cord Stem Cell Bank at the Barbara Ann Karmanos Cancer Institute will receive a $1.4 million, three-year, contract award from the Department of Health and Human Services’ Health Resources and Services Administration to expand its cord blood collection program. [Karmanos Cancer Institute Press Release]
 
Combining Stem Cell and Gene Therapy Techniques to Tackle a Deadly Blood Disease
The National Institutes of Health has awarded a three-year, $3.9 million grant to Children’s Hospital Boston researchers and their colleagues to develop a therapy to treat Fanconi anemia. [Children’s Hospital Boston Press Release]

NIH Renews Georgia Tech-Led Nanomedicine Center for $16.1 Million
The Georgia Tech-led Nanomedicine Center for Nucleoprotein Machines has received an award of $16.1 million for five years as part of its renewal by the National Institutes of Health (NIH). The eight-institution research team plans to pursue development of a clinically viable gene correction technology for single-gene disorders and demonstrate the technology’s efficacy with sickle cell disease. [Georgia Institute of Technology Press Release]

CIRM Funds $72 Million to Translate Basic Discoveries into New Therapies, Recruit Stem Cell Leaders to California
The California Institute for Regenerative Medicine (CIRM) approved funding for 19 awards worth $67 million in its second round of awards designed to move good ideas out of the lab and into the clinic. [California Institute for Regenerative Medicine Press Release]
 
Over 400 Top Researchers Selected in the European Research Council’s Third Prestigious ‘Starting Grant’ Competition
The European Research Council is awarding some EUR 580 million to 427 early career top researchers in its competition for ‘Starting Grants’. Worth up to EUR 2 million each, the grants will enable them to carry out their pioneering ideas in any field of research, throughout Europe. [European Research Council Press Release]

BMTbase™ 4.1 Nearing Release
STEMSOFT Software Inc., the leading provider of software solutions for the cell therapy and transplant community, is pleased to announce the upcoming release of BMTbase® version 4.1.  BMTbase 4.1 includes extended support for AGNIS® with the ability to retrieve the pre-TED, post-TED, death and infectious disease reporting forms. [STEMSOFT Software Inc. Press Release]

Cryo-Cell International Launches Cryology RTS®
Cryo-Cell International, Inc. announced plans at the annual meeting of the American Society of Reproductive Medicine to launch Cryology RTS®, a new reproductive tissue storage service for cryopreserved embryos, oocyctes and sperm. [Cryo-Cell International, Inc. Press Release]
 
Soligenix Announces Preliminary Results of Its Phase II Clinical Trial of orBec® in the Prevention of Acute GVHD
Soligenix, Inc. reported preliminary results from its Phase II “proof-of-concept” exploratory clinical trial of orBec® for the prevention of acute graft versus host disease (GVHD) in patients undergoing myeloablative conditioning regimens with initiation of dosing prior to hematopoietic cell transplantation and continuing through the post-transplantation period. [Soligenix, Inc. Press Release]
 
Stem Cell Central: The Lorry I. Lokey Building
The Lokey Building, an incredible new laboratory facility, is built on a design championed by faculty to facilitate research in one of the most exciting interdisciplinary areas of the 21st century — stem cell biology and regenerative medicine. [Stanford University School of Medicine Press Release]

POLICY NEWS

NIH Recovery Act Grants to Foster Scientific Workforce Diversity
The National Institutes of Health has awarded six grants totaling approximately $12 million over three years through a new initiative aimed at fostering a diverse scientific workforce. [National Institutes of Health, United States]
 
NIH Recovery Act Awards Enable Crucial Health Research Technologies
Thanks to the Recovery Act, more health scientists now will have access to state-of-the-art devices, the National Institutes of Health announced. Through its National Center for Research Resources, NIH has awarded $300 million in shared instrumentation grants. [National Institutes of Health, United States]

White House Science Office Sued Over ‘Scientific Integrity’ Docs
Public Employees for Environmental Responsibility has filed a lawsuit seeking an explanation for why the Obama Administration is 18 months late on delivering its promised guidelines on scientific integrity for the federal government. [Public Employees for Environmental Responsibility, United States]

Secretarial Review and Publication of the Annual Report to Congress Submitted by the Contracted Consensus-Based Entity Regarding Performance Measurement (FR Doc. 2010-26795) [Department of Health and Human Services, United States]

Agency Emergency Information Collection Clearance Request for Public Comment (FR Doc. 2010-26753) [Department of Health and Human Services, United States]
 
Request for Notification From Industry Organizations Interested in Participating in the Selection Process for Nonvoting Industry Representatives on Public Advisory Committees and Panels and Request for Nonvoting Industry Representatives on Public Advisory Committees and Panels [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]
 
Cellular, Tissue and Gene Therapies Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Cellular, Tissue and Gene Therapies Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

National Heart, Lung, and Blood Institute; Notice of Closed Meeting (FR Doc. 2010-26889) [National Institutes of Health, United States]

Guidelines for Use of Stored Specimens and Access to Ancillary Data and Proposed Cost Schedule: Stored Biologic Specimens and Ancillary Data From the Collaborative Perinatal Project (CPP) (FR Doc. 2010-27183) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27192) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27185) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27049) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27040) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27039) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-26935) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26881) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-26702) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-26706) [National Institutes of Health, United States]
 
Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-27187) [National Institutes of Health, United States]


EVENTS (Listed by Date)

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010
Singapore

NEW In Vitro Toxicology Society Annual Meeting
November 2-3, 2010
Liverpool, United Kingdom

2010 National GvHD Symposium
November 4, 2010
Cleveland, United States

World Cord Blood Congress
November 4-7, 2010
Marseille, France

Cambridge Healthtech Institute’s Inaugural Stem Cells in Drug Discovery and Development
November 8-9, 2010
San Diego, United States

NEW Third Annual Research Experience of Stem Cells in European (RESCUE) Society Conference
November 8-9, 2010
Oxford, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

NEW Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

NEW IQPC’s 4th Biobanking Conference
January 24-26, 2011
Philadelphia, United States

BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

NEW 1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Hematopoiesis
March 27-April 1, 2011
Big Sky, United States

NEW United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

Visit
our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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