Volume 2.43 | Nov 18

Cord Blood News 2.43, November 18, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


The Tetraspanin CD9 Regulates Migration, Adhesion and Homing of Human Cord Blood CD34+ Hematopoietic Stem and Progenitor Cells 
To investigate the transcriptional regulation provided by stromal cell-derived factor-1 (SDF-1)/CXCR4 axis, researchers performed the first differential transcriptome profiling of human cord blood CD34+ cells in response to a short-term exposure of SDF-1, and identified a panel of genes with putative homing functions. [Blood]



Launching ISCT’s Inaugural Commercial Development Focus Group on Peripheral Vascular Disease
Read more on how ISCT is pursuing a greater strategic alignment with its industry members in the free ISCT Industry White Paper. [International Society for Cellular Therapy]

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Umbilical Cord Cells May Treat Arthritis, Studies Suggest
Umbilical cord stem cells may be useful in the treatment of rheumatoid arthritis. Animal and in vitro experiments have shown that mesenchymal stem cells taken from umbilical cord blood can suppress inflammation and attenuate collagen-induced arthritis. [Press release from EurekAlert! discussing online prepublication in Arthritis Research and Therapy]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Outcomes After Related and Unrelated Umbilical Cord Blood Transplantation for Non-Fanconi Hereditary Bone Marrow Failure
In patients with hereditary bone marrow failure syndromes, related umbilical cord blood transplant is associated with excellent outcomes while in unrelated umbilical cord blood transplant increasing cell dose and better HLA matching might provide better results. [Haematologica]
Therapeutic Potential of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis
Human umbilical cord (UC)-mesenchymal stem cells (MSCs) suppressed the various inflammatory effects of fibroblast-like synoviocytes and T cells of rheumatoid arthritis in vitro, and attenuated the development of collagen-induced arthritis in vivo, strongly suggesting that UC-MSCs might be a therapeutic strategy in rheumatoid arthritis. [Arth Res Ther]
Intravenous Human Umbilical Cord Blood Transplantation for Stroke: Impact on Infarct Volume and Caspase-3-Dependent Cell Death in Spontaneously Hypertensive Rats
Researchers aimed to evaluate the potential neuroprotective effects produced by human umbilical cord blood cells in terms of reduced infarct volume and caspase-3-dependent cell death. [Exp Neurol]
Hematopoietic Stem Cell Transplantation Does Not Retard Disease Progression in the Psycho-Cognitive Variant of Late-Onset Metachromatic Leukodystrophy
Researchers report detailed clinical and neuropsychological assessments after hematopoietic stem-cell transplantation in a patient with a late-onset psycho-cognitive form of metachromatic leukodystrophy. [J Inherit Metab Dis]
Differential Survival of AML Subpopulations in NOD/SCID Mice
Bone marrow cells from patients with acute myeloid leukemia (AML) were separated according to CD34 expression, aldehydehydrogenase activity and divisional kinetics in comparison to cord blood-derived CD34+ hematopoietic stem cells, evaluating survival and expansion in NOD/SCID mice. [Exp Hematol]

Polychromatic Flow Cytometry Analysis of CD34+ Hematopoietic Stem Cells in Cryopreserved Early Preterm Human Cord Blood Samples
Results evidence the hematopoietic peculiarity of human early preterm cord blood, potentially useful for highlighting early steps of human hematolymphopoiesis as well as for developing novel strategies of stem cell-based therapy. [Cytometry A]
Schwann Cell-Like Remyelination Following Transplantation of Human Umbilical Cord Blood (hUCB)-Derived Mesenchymal Stem Cells in Dogs with Acute Spinal Cord Injury
Researchers conducted preliminary investigations on the remyelination of injured spinal cords with hUCB-mesenchymal stem cell transplantations and observed its long term effects on dogs with spinal cord injury. [Journal Neurol Sci]

Hematopoietic Stem Cell Transplantation in Severe Congenital Neutropenia
Since 2004, eight hematopoietic stem cell transplantations were performed in seven patients. Three grafts were from HLA-identical siblings, three from matched unrelated donors and two were cord blood units. [Pediatr Blood Cancer]

Relationship Between Radiosensitivity of Human Neonatal Hematopoietic Stem/Progenitor Cells and Individual Maternal/Neonatal Obstetric Factors
The study investigated the potential relationship between the radiosensitivity of hematopoietic stem/progenitor cells in placental/umbilical cord blood, which was obtained from singleton and full-term deliveries, and maternal/neonatal obstetric factors. [J Radiat Res]
Enhanced Osteogenic Differentiation of Cord Blood-Derived Unrestricted Somatic Stem Cells on Electrospun Nanofibers
Observations suggested the enhanced proliferation and osteogenic differentiation of cord blood-derived unrestricted somatic stem cells on poly-L-lactide-collagen nanofiber scaffolds and introduced a new combination of stem cell-scaffold constructs with desired characteristics for application in bone tissue engineering. [J Mater Sci Mater Med]



Cord Blood America Becomes Alliance Partner of National Association Representing U.S. Health Insurance Plans
Cord Blood America, Inc. announced that it is the first cord blood stem cell storage company to become an alliance partner of AHIP (America’s Health Insurance Plans). [Cord Blood America, Inc. Press Release]
Potential Blood Center Merger
Three of Florida’s largest independent, not-for-profit blood banks, Community Blood Centers of Florida, Florida’s Blood Centers and Florida Blood Services announced that they have received approval from each of their boards of directors to explore the option of merging into one organization. [Florida’s Blood Center Press Release]
St. Louis Cord Blood Bank Wins $1.4 Million Grant
The St. Louis Cord Blood Bank received a three-year, $1.4 million federal grant. The contract from the Office of Health Resources and Services Administration within the U.S. Department of Health and Human Services is for collection and maintenance of genetically diverse umbilical cord blood units, especially those from minority parents, the blood bank said. [St. Louis Business Journal]

StemCyte Awarded $488,950 for Advanced Therapeutic Applications of Umbilical Cord Blood Stem Cells from the Qualifying Therapeutic Discovery Project
StemCyte, Inc. announced that the Company has been awarded two cash grants totaling $488,950 under the U.S. Internal Revenue Service’s Qualifying Therapeutic Discovery Project program. [PR Newswire]

China Cord Blood Corporation Commences Warrant Exchange Offer
China Cord Blood Corporation commenced its previously announced warrant exchange offer, and provided warrant holders with participation details. [China Cord Blood Corporation Press Release]
NeoStem Announces Pricing of Concurrent Offerings for $19 Million in Gross Proceeds
NeoStem, Inc., an international biopharmaceutical company with product and service revenues, global research and development capabilities and operations in three distinct business units, U.S. adult stem cells, China adult stem cells, and China pharmaceuticals announced the pricing of concurrent offerings. [NeoStem, Inc. Press Release]

Stem Cells Journal Awards Human Cord-Blood Research
The journal Stem Cells has announced Dr. Cinzia Rota as the winner of the annual Stem Cells Young Investigator Award. Dr. Rota, from the Mario Negri Institute for Pharmacological Research in Bergamo, Italy, was awarded the prize for her paper entitled ‘Life-Sparing Effect of Human Cord Blood-Mesenchymal Stem Cells in Experimental Acute Kidney Injury.’ [EurekAlert!]


European Medicines Agency and Massachusetts Institute of Technology Launch Joint Project on Regulatory Science
The European Medicines Agency and the Massachusetts Institute of Technology’s Center for Biomedical Innovation and Center for International Studies are launching a collaborative research project with a focus on enhancing regulatory science in pharmaceuticals. [European Medicines Agency, European Union]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)
Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS (Listed by Date)

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

NEW The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

IQPC’s 4th Biobanking Conference
January 24-26, 2011
Philadelphia, United States

NEW Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

NEW Stem Cells 2011 – Innovation & Commercialisation
February 23-24, 2011
London, United Kingdom

Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

NEW 15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

March 22, 2011
Farmington, United States

Keystone Symposia: Hematopoiesis
March 27-April 1, 2011
Big Sky, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Lab Technologist — Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist — Tissue Culture (STEMCELL Technologies)

Product Manager — Pluripotent Stem Cells (STEMCELL Technologies)

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