Volume 2.44 | Nov 25

Cord Blood News 2.44, November 25, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events


Reprogrammed Amniotic Fluid Cells Can Generate All Types of Body Cells 
Scientists have now managed to convert amniotic fluid cells into pluripotent stem cells. [Press release from the Max Planck Society discussing online prepublication in PLoS One]



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A Decade of Refinements in Marrow and Stem Cell Transplantation Improves Long-Term Survival of Blood Cancers
A decade of refinements in marrow and stem cell transplantation to treat blood cancers significantly reduced the risk of treatment-related complications and death. [Press release from the Fred Hutchinson Cancer Research Center discussing online prepublication in the New England Journal of Medicine]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Reduced Mortality After Allogeneic Hematopoietic-Cell Transplantation
Researchers found a substantial reduction in the hazard of death related to allogeneic hematopoietic-cell transplantation, as well as increased long-term survival, over the past decade. [N Engl J Med]
Autologous Hematopoietic Stem Cell Transplantation in Chronic Lymphocytic Leukemia: Results of European Intergroup Randomized Trial Comparing Autografting Versus Observation
Researchers present results of a Phase III randomized trial of autografting in chronic lymphocytic leukemia versus observation for responding patients after first or second line treatment. [Blood]
Human Placenta-Derived Adherent Cells Prevent Bone Loss, Stimulate Bone Formation, and Suppress Growth of Multiple Myeloma in Bone
The study suggests that altering the bone marrow microenvironment with placenta-derived adherent cells (PDAC) cytotherapy attenuates growth of myeloma and that PDAC cytotherapy is a promising therapeutic approach for myeloma osteolysis. [Stem Cells]

The LARGE Principle of Cellular Reprogramming: Lost, Acquired and Retained Gene Expression in Foreskin and Amniotic Fluid-Derived Human iPS Cells
Researchers report the generation and characterization of human amniotic fluid-derived induced pluripotent stem (iPS) cells and demonstrate their ability to differentiate into the trophoblast lineage after stimulation with BMP2/BMP4. [PLoS One]

Low Usage Rate of Banked Sibling Cord Blood Units in Hematopoietic Stem Cell Transplantation for Children with Hematological Malignancies: Implications for Directed Cord Blood Banking Policies
Researchers evaluated the effectiveness of a national directed cord blood banking program in sibling HLA-identical stem cell transplantation for hematological malignancies and the factors influencing the usage rate of the stored cord blood units. [Blood Cells Mol Dis]

Graft Failure in Cord Blood Transplantation Successfully Treated with Short-Term Reduced-Intensity Conditioning Regimen and Second Allogeneic Transplantation
In 36 adult patients undergoing cord blood transplantation at the researchers’ hospital between July 2003 and December 2009, six patients developed graft failure. All six patients underwent second stem cell transplantation (SCT). All patients achieved neutrophil engraftment, and the median elapsed time from second SCT to engraftment was 35 days. [Int J Hematol]
Differentiating of Banked Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells into Insulin-Secreting Cells
Results showed that mesenchymal stem cells derived from banked cord blood can differentiate into functional pancreatic islet-like cells in vitro. [In Vitro Cell Dev Biol Anim]


National Marrow Donor Program® to Speed Transplants with IBM Analytics Software
IBM announced that the National Marrow Donor Program® has adopted IBM’s WebSphere Lombardi Business Process Management software to help automate its donor and patient management process. [IBM Press Release]
A New Collaboration with Tokyo Women´s Medical University
Karolinska Institutet and the Institute of Advanced Biomedical Engineering and Science, Tokyo Women´s Medical University have agreed to collaborate on education and biomedical research. [Karolinska Institutet Press Release]
Pfizer Launches Global Centers for Therapeutic Innovation, a Network of Research Partnerships, with University of California, San Francisco
Pfizer Inc. announced the establishment of the Global Centers for Therapeutic Innovation, an entrepreneurial network of partnerships with leading academic medical centers to transform research and development by accessing leading translational researchers. [Pfizer Inc. Press Release]
NeoStem Announces Closing of Concurrent Offerings for $19 Million in Gross Proceeds
NeoStem, Inc. announced the closing of concurrent offerings. [NeoStem, Inc. Press Release]

China Cord Blood Corporation Reports Second Quarter and First Half Fiscal 2011 Financial Results
China Cord Blood Corporation announced unaudited financial results for the second quarter and first half of fiscal 2011 ended September 30, 2010. [China Cord Blood Corporation Press Release]
Canadian Blood Services Seeking $48 Million for Umbilical Cord Blood Bank
Canadian Blood Services is in negotiations with provincial and territorial governments over funding to create a national bank for umbilical cord blood, and is hopeful the cash will be secured soon so the life-saving registry can be established. [The National Post]

Roche Announces Implementation Plans for Its Operational Excellence Program
Following a comprehensive portfolio review, Roche will discontinue certain activities in research and early development. These include RNA interference research in Kulmbach, Germany, and in Nutley, New Jersey, and Madison, Wisconsin, in the U.S. [Roche Press Release]


European Research Body to Get New Head
The European Research Council (ERC) is about to get a new leader, although not in the form most people expected. Helga Nowotny, chair of the ERC’s Scientific Council, a new secretary-general has been chosen to replace Andreu Mas-Colell, who stepped down for personal reasons in September. [European Research Council, European Union]

Committee for Advanced Therapies Adopts Five-Year Work Program to Foster Development of Advanced Therapies
The European Medicines Agency’s Committee for Advanced Therapies has unveiled a Work Program to 2015, intended to help increase the number of advanced-therapy medicinal products that make it from the early research stage to the market. [European Medicines Agency, European Union]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)
Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS (Listed by Date)

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

IQPC’s 4th Biobanking Conference
January 24-26, 2011
Philadelphia, United States

Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

Stem Cells 2011 – Innovation and Commercialisation
February 23-24, 2011
London, United Kingdom

Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

StemCONN 11
March 22, 2011
Farmington, United States

Keystone Symposia: Hematopoiesis
March 27-April 1, 2011
Big Sky, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

NEW Inaugural Theranostics for Personalised Medicine
May 18-19, 2011
London, United Kingdom
NEW 13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Lab Technologist — Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist — Tissue Culture (STEMCELL Technologies)

Product Manager — Pluripotent Stem Cells (STEMCELL Technologies)

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