Volume 3.08 | Mar 3

Cord Blood News 3.08, March 3, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
 
TOP STORY
Human Cord Blood CD34+ Progenitor Cells Acquire Functional Cardiac Properties Through a Cell Fusion Process
The aims of the present work are to investigate whether human CD34+ cells, isolated after a week of co-culture with neonatal ventricular myocytes, possess molecular and functional properties of cardiomyocytes and to discriminate, using a reporter gene system, whether cardiac differentiation derives from a (trans)differentiation or a cell fusion process. [Am J Physiol Heart Circ Physiol]

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SCIENCE NEWS
How Long Do Stem Cells Live?
To help determine how long a bone marrow (stem cell) graft will last, researchers have developed a mathematical model that predicts how long a stem cell will live and tested those predictions in a mouse model. [Press release from Sanford-Burnham Medical Research Institute discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Chromatin Modifying Agents Promote the Ex Vivo Production of Functional Human Erythroid Progenitor Cells
Researchers have developed an ex vivo generated transfusion products composed of erythroid progenitor cells and precursors cells. [Blood]

Predicting Clonal Self-Renewal and Extinction of Hematopoietic Stem Cells
Results indicate that each hematopoietic stem cell (HSC) is programmed to have a finite life span. This program and the memory of the life span of the mother HSC are inherited by all daughter HSCs. In contrast, there was extensive heterogeneity in life spans between individual HSC clones. [Proc Natl Acad Sci U S A]

Alveolar Epithelial Cell Therapy with Human Cord Blood-Derived Hematopoietic Progenitor Cells
Researchers investigated the capacity of human umbilical cord blood-derived CD34+ hematopoietic progenitor cells to regenerate injured alveolar epithelium in newborn mice. [Am J Pathol]

Human T Cell Development in the Liver of Humanized NOD/SCID/IL-2R(Gamma)null (NSG) Mice Generated by Intrahepatic Injection of CD34+ Human (h) Cord Blood(CB) Cells
Results demonstrate that the intrahepatic injection of hCD34+ CB cells can facilitate human T cell development in the livers of humanized NSG mice. [Clin Immunol]

Synergistic Effects of Growth Factors and Mesenchymal Stromal Cells for Expansion of Hematopoietic Stem and Progenitor Cells
The supportive effect of mesenchymal stromal cells on hematopoiesis can be significantly increased by addition of specific recombinant growth factors – especially in combination with stem cell factor, thrombopoietin and fibroblast growth factor 1. [Exp Hematol]

Severe Pruritus and Hypothermia as the Primary Manifestations of Human Herpes Virus-6 Encephalitis After Pediatric Cord Blood Transplantation
Viral encephalitis has a reported incidence of 1.2-4% in prospective evaluations of allogeneic hematopoietic stem cell transplantation patients. [Bone Marrow Transplant]

Open Cardiac Surgery in the First Hours of Life Using Autologous Umbilical Cord Blood
This article describes the first clinical experience of complete repair of complex critical congenital heart diseases in the first hours of life using autologous umbilical cord blood. [Eur J Cardiothorac Surg]

Protective Effects of Human Umbilical Cord Blood Stem Cell Intravitreal Transplantation Against Optic Nerve Injury in Rats
Via intravitreal transplantation, human umbilical cord blood stem cells resulted in a significant increase in the survival of the retinal ganglion cells, and improved pathological changes in the rat retina, following traumatic optic neuropathy. [Graefes Arch Clin Exp Ophthalmol]

INDUSTRY NEWS
Cord Blood America Announces Asset Purchase
Cord Blood America, Inc. announced that it has purchased all the umbilical cord blood samples and the related laboratory equipment from Reproductive Genetics Institute, Inc., based in Chicago, Illinois. [Cord Blood America, Inc. Press Release]

SymBio Pharmaceuticals Successfully Completes JPY2.0 Billion (USD24 Million) Series E Private Placement
SymBio Pharmaceuticals Limited announced that the company has completed a JPY2.0 billion (USD24 million) private placement of Series E common stock led by two existing shareholders, Cephalon, Inc. and JAFCO Co., Ltd., a leading private equity firm in Japan. [SymBio Pharmaceuticals Limited Press Release]
 
China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results
China Cord Blood Corporation announced unaudited financial results for the third quarter and first nine months of fiscal year 2011 ended December 31, 2010. [China Cord Blood Corporation Press Release]

NeoStem to Launch New Service and Has Engaged Healthcare Personality Dr. Manny Alvarez to Serve as Spokesperson
NeoStem, Inc. announced that Dr. Manny Alvarez, an esteemed Obstetrician and Gynecologist and recognized television and online healthcare professional, will become the spokesperson and public representative of NeoStem’s adult stem cell banking and cord blood banking programs. [NeoStem Inc. Press Release]

Genecell International Underscores Importance of Cord Blood Stem Cells in Meeting Minority Marrow Needs
GeneCell International, an international leader in the processing and preservation of umbilical cord blood stem cells, announced that it seeks to address the shortage of cord blood available for minority patients. [PRWeb]
POLICY NEWS
Lawmakers: Connecticut Cord Blood Bank Is Moving Forward
A bipartisan group of state legislators said Tuesday that Connecticut is moving closer to becoming the latest state to participate in a national effort to bank umbilical cord blood, a source of valuable stem cells. [Connecticut General Assembly’s Public Health Committee, United States]


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW 2nd International Hematologic Malignancies Conference: Bridging the Gap 2011
March 18-20, 2011
Singapore, Singapore

NEW The International Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM)
September 8-11, 2011
Berlin, Germany

NEW American Association of Blood Banks Annual Meeting & CTTXPO 2011
October 22-25, 2011
San Diego, United States

NEW World Cord Blood Congress III: Cord Blood Transplantation and Immunobiology of Haematopoietic Stem Cell Transplant
October 27-30, 2011
Rome, Italy

NEW Cell Therapy Manufacturing – Stem Cells and Immunotherapeutics
December 1-2, 2011
London, United Kingdom

NEW Stem Cell Programming & Reprogramming
December 8-11, 2011
Lisbon, Portugal

Visit our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Cell Therapy Manufacturing Manager (Opexa Therapeutics)

Postdoctoral Fellow (The Henry M. Jackson Foundation)

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