Volume 3.09 | Mar 10

Cord Blood News 3.09, March 10, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
 
TOP STORY
Enforced Expression of MLL-AF4 Fusion in Cord Blood CD34+ Cells Enhances the Hematopoietic Repopulating Cell Function and Clonogenic Potential But Is Not Sufficient to Initiate Leukemia
Researchers explored in vitro and in vivo the impact of the enforced expression of MLL-AF4 in human cord blood-derived CD34+ hematopoietic stem or progenitor cells. [Blood]

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SCIENCE NEWS
Transplanting Umbilical Cord and Menstrual Blood-Derived Stem Cells Offer Hope for Disorders
Transplanting stem cells derived from umbilical cord blood cells and menstrual blood cells may offer future therapeutic benefit for those suffering from stroke, Alzheimer’s disease, and amyotrophic lateral sclerosis. [Press release from EurekAlert! discussing online prepublication in Cell Transplantation]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

HHV-6 Reactivation and Its Effect on Delirium and Cognitive Functioning in Hematopoietic Cell Transplant Recipients
Patients with HHV-6 were more likely to develop delirium (adjusted odds ratio (aOR) 2.5; 95% confidence interval (CI) 1.2-5.3) and demonstrate neurocognitive decline (aOR 2.6; 95% CI 1.1-6.2) in the first 84 days post hematopoietic cell transplantation. Cord blood and unrelated transplantation increased risk of HHV-6 reactivation. [Blood]

Amniotic Liquid Derived Stem Cells as Reservoir of Secreted Angiogenic Factors Capable of Stimulating Neo-Arteriogenesis in an Ischemic Model
Researchers used human amniotic fluid stem cells (AFSC) to evoke a strong angiogenic response in murine recipients, in terms of host guided-regeneration of new vessels, and we demonstrated that the AFSC secretome is responsible for the vascularizing properties of these cells. [Biomaterials]

The Treatment of Neurodegenerative Disorders Using Umbilical Cord Blood and Menstrual Blood-Derived Stem Cells
Mononuclear umbilical cord blood cells and menstrual blood-derived stem cells, particularly umbilical cord blood cells, have been studied as either single or multiple injections in a number of animal models of neurodegenerative disorders with some degree of success, including stroke, Alzheimer’s disease, amyotrophic lateral sclerosis, and Sanfilippo syndrome type B. [Cell Transplant]

MMP-2 Mediates Mesenchymal Stem Cell Tropism Towards Medulloblastoma Tumors
Researchers conclude that human umbilical cord blood-derived stem cells can integrate into human medulloblastoma after local delivery and that matrix metalloproteinase (MMP)-2 expression by the tumor cells mediates this response through the stromal cell-derived factor 1/CXCR4 axis. [Gene Ther]

Unrelated Cord Blood Transplantation for Thalassemia: A Single-Institution Experience of 35 Patients
Data compare acceptably with the survival rates of related-donor BMT for thalassemia and suggest that patients without an available HLA-compatible sibling but who have well-matched unrelated donors should also be considered for cord blood transplantation. [Bone Marrow Transplant]

Identification and Frequency of CCR5Δ32/Δ32 HIV-Resistant Cord Blood Units from Houston Area Hospitals
Routine genotyping to identify HIV-resistant cord blood (CB) units could create a bank of CB-derived stem/progenitor cells with which to treat HIV infection. [HIV Med]

Successful Treatment with Combined Chemotherapy of Two Adult Cases of Hemophagocytic Lymphohistiocytosis in Recipients of Umbilical Cord Blood Cell Transplantation
The combined use of low-dose etoposide and vincristine plus prednisolone appears to be a promising treatment option for hematopoietic stem cell transplantation-hemophagocytic lymphohistiocytosis, without serious adverse side effects. [Int J Hematol]

MARCH-I Expression in Cord Blood CD34+KDR+ Cells
MARCH-I expression in stem cells could be important for their intrinsic immune properties. [Clin Biochem]

The Preparation and Storage of Dried-Blood Spot Quality Control Materials for Lysosomal Storage Disease Screening Tests
Umbilical-cord blood is the preferred matrix for lysosomal storage disease-normal dried-blood spot quality control materials. [Clin Biochem]

Delivery of Fibroblast Growth Factor 2 Enhances the Viability of Cord Blood-Derived Mesenchymal Stem Cells Transplanted to Ischemic Limbs
Researchers hypothesized that local delivery of fibroblast growth factor 2 to the site of cord blood-derived mesenchymal stem cell (CBMSC) transplantation would enhance the viability of CBMSCs transplanted to ischemic tissues. [J Biosci Bioeng]

INDUSTRY NEWS
Fenwal and Golden Meditech Complete Definitive Agreement for Joint Venture in China
Fenwal Inc. and Golden Meditech Holdings Limited announced they have entered into a definitive agreement to form a joint venture in China that will sell advanced products and technologies for blood collection, storage and transfusion. [Fenwal Inc. Press Release]

Thermogenesis Announces Pricing of Offering
ThermoGenesis Corporation said that it has determined the pricing for an offering of shares and warrants. [ThermoGenesis Corporation Press Release]

Case Western Reserve Positions Regenerative Medicine Center for Future Growth
In a move to streamline and accelerate the research and development of new stem cell and regenerative medicine technologies, the National Center for Regenerative Medicine and the Center for Stem Cell and Regenerative Medicine at Case Western Reserve University have been rolled into a single entity housed within the university’s School of Medicine. [Case Western Reserve University Press Release]

Foals’ Umbilical Cords Can Be Banked for Future Stem Cell Treatments
Horse owners now have the opportunity to collect umbilical cord tissue immediately after a foal is born and save it as a future source of therapeutic stem cells through the Regenerative Medicine Laboratory at University of California Davis’ School of Veterinary Medicine. [University of California, Davis Press Release]

Saint Luke’s Cord Blood Donation Program Reaches Milestone
Saint Luke’s cord blood donation program – the only one in the region – recently collected its 2000th cord blood unit. [Saint Luke’s Health System Press Release]

Big Breach at Cord Blood Registry
The Cord Blood Registry, which stores more than 350,000 cord blood collections for individuals and their families, has notified about 300,000 individuals of a breach of their protected health information. [Health Data Management]

Miriam Gonzalez Calls for Investment into Cord Blood
Miriam Gonzalez, wife of Deputy Prime Minister Nick Clegg, hosted her first political reception in aid of Anthony Nolan, to raise awareness about cord blood. [The Anthony Nolan Trust Press Release]
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW International Conference and Exhibition on Cancer Science & Therapy
August 15-17, 2011
Las Vegas, United States

NEW Adult MSC2011: Innovations in Cell-Based Regenerative Therapies
August 22-24, 2011
Cleveland, United States

Visit our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Cell Therapy Manufacturing Manager (Opexa Therapeutics)

Postdoctoral Fellow (The Henry M. Jackson Foundation)

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