Volume 3.10 | Mar 17

     In this issue: Science News | Current Publications | Industry News | Policy News | Events
 
TOP STORY
Hematopoietic Stem/Progenitor Cells, Generation of Induced Pluripotent Stem Cells, and Isolation of Endothelial Progenitors from 21-23.5 Year Cryopreserved Cord Blood
Researchers evaluated recovery of functional hematopoietic progenitor cells cryopreserved as mononuclear or unseparated cells for up to 23.5 years compared to pre-freeze values of the same cord blood units. [Blood]

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SPECIAL FEATURE

Webinar: ALDHbr Cells and Regenerative Medicine
Aldehyde Dehydrogenase bright (ALDHbr) cells have been used in preclinical models and human clinical trials in applications such as critical limb ischemia, ischemic stroke, acute liver failure and ischemic heart failure.1 Learn more about how ALDHbr cells could be used in regenerative medicine by registering today for an exclusive webinar presented by Dr. Andrew E. Balber of Cicada Biopharmaceutical Consulting.

Join us on April 7 at:
10AM EST (ideal for Europe) | 2PM EST (ideal for Americas) | 8PM EST (ideal for Asia-Pacific)


1
Reviewed in Balber AE. Stem Cells (in press). DOI: 10.1002/stem.613.
Dr. Balber holds equity in and is a consultant to Aldagen, Inc., a company that is developing research, diagnostic, and therapeutic products based on detecting and isolating ALDHbr cells.



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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Hepatic Differentiation of Amniotic Epithelial Cells
Amniotic epithelial cells possess the ability to differentiate into cells with characteristics of functional hepatocytes, in vitro and in vivo, thus representing a useful and non controversial source of cells for transplantation. [Hepatology]

Allogeneic Hematopoietic Stem Cell Transplantation Overcomes the Adverse Prognostic Impact of CD20 Expression in Acute Lymphoblastic Leukemia
Results can serve as a reference to evaluate incorporation of anti-CD20 therapeutics to hematopoietic stem cell transplantation for the CD20+ acute lymphoblastic leukemia subset. [Blood]

Autologous Stem Cell Transplantation as a First-Line Treatment Strategy for Chronic Lymphocytic Leukemia: A Multicenter Randomized Controlled Trial
Researchers conducted a prospective randomized trial of autologous stem cell transplantation in previously untreated chronic lymphocytic leukemia patients. [Blood]

Cardiac Tamponade Potentially Related to Sirolimus Following Cord Blood Transplantation
Researchers present the case of a 28-year-old female patient with advanced myelodysplastic syndrome. [Bone Marrow Transplant]

Initial CD34+ Cell-Enrichment of Cord Blood Determines Hematopoietic Stem/Progenitor Cell Yield Upon Ex Vivo Expansion
Findings stress the importance of establishing a balance between the cell proliferative potential and cell recovery upon purification, towards the efficient and cost-effective expansion of hematopoietic stem/progenitor cells for cellular therapy. [J Cell Biochem]

Ex Vivo Rapamycin Treatment of Human Cord Blood CD34+ Cells Enhances Their Engraftment of NSG Mice
Since overexpression of Rheb2 leads to increased signaling through mTOR, researchers examined the effect of the mTOR inhibitor rapamycin ex vivo on cytokine expanded CD34+ cord blood cells for the engraftment of these cells in non-obese diabetic, severe combined immunodeficient, IL-2 receptor γ chain null (NSG) mice. [Blood Cells Mol Dis]

Secondary Pulmonary Alveolar Proteinosis After Unrelated Cord Blood Hematopoietic Cell Transplantation
Researchers observed two cases of pulmonary alveolar proteinosis after unrelated cord blood hematopoietic progenitor cell transplantation in children with ALL. [Pediatr Transplant]

The Methods Used to Collect Hematopoietic Stem Cells
The methods used to collect hematopoietic stem cells in their natural environment (bone marrow or cord blood) or in the peripheral blood after stimulation are well-defined and ruled both to ensure the donor security and perform a quality hematopoietic transplantation. [Transfus Clin Biol]

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INDUSTRY NEWS
UMass, U.K. Stem Cell Banks Sign Agreement
As part of Governor Deval Patrick’s Innovation Economy Partnership Mission 2011, global leaders in the field of stem cell banking and characterization—the University of Massachusetts (UMass) Human Stem Cell Bank and Registry and the United Kingdom Stem Cell Bank—signed an agreement to share best practices for stem cell banking and to collaborate on standards for stem cell line characterization, production and distribution in the U.S. and U.K. [University of Massachusetts Medical School Press Release]

Cellectis and the Etablissement Français du Sang Launch StemRed, a Program to Produce Red Blood Cells from Stem Cells
Cellectis and Etablissement Français du Sang announce that StemRed, an ambitious collaborative program to produce red blood cells from induced pluripotent stem cells has started. [Cellectis Press Release]

Pluristem Therapeutics and NYU Medical Center Partner to Study Use of PLX Cells in Treatment of Diabetic Foot Ulcers
Pluristem Therapeutics, Inc. and New York University (NYU) Medical Center announced the formation of a partnership to study the use of Pluristem’s proprietary placenta-derived PLX cells for the treatment of Diabetic Foot Ulcers. [Pluristem Therapeutics, Inc. Press Release]

Fortis Healthcare Ties Up with TotipotentRX to Set Up Stem Cell Therapy Center
Fortis Healthcare Ltd. and TotipotentRX Cell Therapy Pvt. Ltd. announced a collaboration to set up centers of excellence offering cellular therapies and stem cell clinical trials across select Fortis hospitals. [Fortis Healthcare Limited Press Release]

Ministers of Health Announce Canada’s First National, Publicly-Funded Umbilical Cord Blood Bank
Provincial and territorial ministries of health (except Quebec) announced a combined investment of $48 million over the next eight years, including $12.5 million in fundraising, to create a national public umbilical cord blood bank that will provide Canadian patients with greater access to cord blood units. [Canadian Blood Services, Press Release]

bluebird bio Awarded up to $4.2 Million from the French Muscular Dystrophy Association for Continued Development of Gene Therapy for Beta-Thalassemia and Sickle Cell Anemia
bluebird bio announced that it has entered into an agreement with the French Muscular Dystrophy Association, a French non-profit entity, whereby the company will receive an initial amount of approximately $1.4 million in cash to support the development of LentiGlobin®, the company’s development-stage program for the treatment of beta-thalassemia and sickle cell anemia. [bluebird bio Press Release]
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW International Society for Cellular Therapy (ISCT) 17th Annual Meeting
May 18-21, 2011
Rotterdam, The Netherlands

NEW American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-21, 2011
Seattle, United States

NEW International Society for Hematology and Stem Cells (ISEH) 40th Annual Scientific Meeting
August 25-28, 2011
Vancouver, Canada


Visit our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Supervisor Cell Therapy Lab (The University of Texas MD Anderson Cancer Center)

Cell Therapy Manufacturing Manager (Opexa Therapeutics)

Postdoctoral Fellow (The Henry M. Jackson Foundation)

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