Volume 3.13 | Apr 7

     In this issue: Science News | Current Publications | Industry News | Policy News | Events
 
TOP STORY
Stimulation of Activin A/Nodal Signaling Is Insufficient to Induce Definitive Endoderm Formation of Cord Blood-Derived Unrestricted Somatic Stem Cells
The aim of this study was to determine the potential of unrestricted somatic stem cells to form definitive endoderm following induction with Activin A, a protein known to specify definitive endoderm formation of human embryonic stem cells. [Stem Cell Res Ther]

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SCIENCE NEWS
Testing Power of Cord Blood
Researchers are seeking ethics approval for a trial at Melbourne’s Monash Medical Centre that would offer umbilical cord blood treatment to 20 children to determine whether it can cure or relieve the symptoms of cerebral palsy. [The Age]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Impact of Immune Modulation with Anti-T Cell Antibodies on Outcomes of Reduced Intensity Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies
Data suggest adopting a cautious approach to routine use of in vivo T-cell depletion with alkylating reduced intensity conditioning regimens. [Blood]

Human Mast Cell Degranulation and Preformed TNF Secretion Require Mitochondrial Translocation to Exocytosis Sites: Relevance to Atopic Dermatitis
Stimulation of human umbilical cord blood-derived mast cells with IgE/antigen or Laboratory of Allergic Diseases 2 cells with substance P leads to rapid (30 minutes) secretion of preformed TNF. [J Allergy Clin Immunol]

What Are a Patient’s Current Chances of Finding a Matched Unrelated Donor? Twenty Years’ Central Search Experience in a Small Country
The strongest factor for both finding a donor and being transplanted was a search being performed during more recent years: patients’ chances increased from year to year. [Bone Marrow Transplant]

Improved Engraftment with Minimal Graft-Versus-Host Disease After Major Histocompatibility Complex-Mismatched Cord Blood Transplantation with Photochemically Treated Donor Lymphocytes
Researchers observed inconsistent donor engraftment after transplantation with cord blood alone, but superior engraftment and long-term survival after fetal near-term peripheral blood transplantation supplemented with psoralen-treated donor T-lymphocytes. [Exp Biol Med]

Optimization of In Vitro Erythropoiesis from CD34+ Cord Blood Cells Using Design of Experiments (DOE)
Researchers used design of experiments methodology to quantitatively define and optimize in vitro erythropoiesis from human cord blood CD34+ cells to enucleation. [Biochem Eng J]

Outcomes, Infections, and Immune Reconstitution After Double Cord Blood Transplantation in Patients with High-Risk Hematological Diseases
Delayed immune recovery and high incidence of infectious complications were observed after double unrelated cord blood transplant in patients with high-risk hematological diseases. [Transpl Infect Dis]

Umbilical Cord Blood Cell Transplantation After Brain Ischemia – From Recovery of Function to Cellular Mechanisms
The therapeutic functional effects of human umbilical cord blood (hUCB) cells observed in animal models make the transplantation of hUCB cells a promising experimental approach in the treatment of ischemic brain injury. [Ann Anat]

Allogeneic Hematopoietic Stem Cell Transplantations
The present experience shows clearly that the allogeneic hematopoietic stem cell transplantation strategy should be developed and refined because of the potential benefit that can be expected in some patients’ sub-groups and then allogeneic hematopoietic stem cell transplantation, real immunotherapy should be included in the global therapeutic strategy in onco-hematology. [Transfus Clin Biol]

INDUSTRY NEWS
Gentium Hosts Symposium on Defibrotide at EBMT Annual Meeting and Sponsors Basic Science Award
Gentium S.p.A. announced that the Company’s lead product, Defibrotide, was the subject of a symposium, “Advances in the Management of Endothelial Complications of Hematopoietic Stem Cell Transplantation: the Emerging Role of Defibrotide,” at the 37th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) in Paris. [Gentium S.p.A. Press Release]

CaridianBCT Revolutionizes Cell Therapy Industry with New Cell Expansion Product
CaridianBCT, a leading global provider of technology, products and services in the blood banking, transfusion medicine and cell therapy industries, announced the launch of a new product, the Quantum Cell Expansion System. [CaridianBCT, Inc. Press Release]

Cord Blood America: Court Grants Motion to Dismiss at Lawsuit Aimed at Blocking Acquisition
Cord Blood America, Inc. (CBAI) is pleased to announce that the Pinellas County Circuit Court granted a motion to dismiss the lawsuit filed by Cryo-Cell International against Cord Blood America, which CBAI management believed was an attempt to inhibit the pending deal between Cryo-Cell Mexico and CBAI. [Cord Blood America, Inc. Press Release]

NeoStem Provides Results for 2010 and an Update on Recent Activities
NeoStem, Inc. provided unaudited results for 2010 and an update of recent activities. [NeoStem, Inc. Press Release]

Cells4Life Appoints New Medical Director in the Region
UK stem cell storage experts, Cells4Life, recently appointed Dr. Ailish O’ Connell as the new medical director for the Middle East. [AME Info]

Stem Cells From Placentas Show Potential in Treating Heart Disease, Multiple Sclerosis, and More
Pluristem Therapeutics processes stem cells obtained from donors’ placentas into a variety of ready-to-use medications, which is more than just cool science–it’s also an indication of where biotech will be headed over the next decade. [Fast Company]

Report to Nation Finds Continued Declines in Many Cancer Rates
Rates of death in the United States from all cancers for men and women continued to decline between 2003 and 2007, the most recent reporting period available, according to the latest Annual Report to the Nation on the Status of Cancer. [National Institutes of Health, United States]
POLICY NEWS
Guidance for Industry: Class II Special Controls Guidance Document: Cord Blood Processing System and Storage Container [Center for Biologics Evaluation and Research, United States]

Advisory Council on Blood Stem Cell Transplantation; Notice of Meeting (FR Doc. 2011-8146) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW Discussion Workshop: Stem Cells
May 6, 2011
London, United Kingdom

NEW 2011 American Society of Clinical Oncology Annual Meeting
June 3-7, 2011
Chicago, United States

NEW 2011 World Stem Cell Summit
October 3-5, 2011
Pasadena, United States

NEW Society for Maternal-Fetal Medicine 32nd Annual Meeting
February 6-11, 2012
Dallas, United States

NEW The 2012 London Regenerative Medicine Event
February 16, 2012
London, United Kingdom

Visit our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Supervisor Cell Therapy Lab (The University of Texas MD Anderson Cancer Center)

Cell Therapy Manufacturing Manager (Opexa Therapeutics)

Research Associate (University College London Institute of Child Health)

INTERBIO-21st Project Coordinator (University of Oxford – Nuffield Department of Obstetrics & Gynaecology)

Senior Scientist (Matchtech)

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