Volume 3.15 | Apr 21

Cord Blood News 3.15, April 21, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Hematopoietic Differentiation of Umbilical Cord Blood-Derived Very Small Embryonic/Epiblast-Like Stem Cells
Data suggest that umbilical cord blood (UCB)-very small embryonic/epiblast-like stem cells correspond to the most primitive population of hematopoietic stem/progenitor cells in UCB. [Leukemia]

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SCIENCE NEWS
Enhanced Cord Blood Stem Cell Transplants Safe in Long-Term Studies
An innovative experimental treatment for boosting the effectiveness of stem cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies, report scientists. [Press release from Dana-Farber Cancer Institute discussing online prepublication in Cell Stem Cell]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models
Dimethyl-prostaglandin E2 significantly increased total human hematopoietic colony formation in vitro and enhanced engraftment of unfractionated and CD34+ human cord blood after xenotransplantation. [Cell Stem Cell]

Contamination of Mesenchymal Stem Cells with Fibroblasts Accelerates Neurodegeneration in an Experimental Model of Parkinson’s Disease
Researchers show for the first time that transplantation of umbilical cord-derived mesenchymal stem cells induced potent neuroprotection in the brain resulting in clinical benefit. [Stem Cell Rev]

Generation of Hematopoietic Humanized Mice in the Newborn BALB/c-Rag2nullIl2rγnull Mouse Model: A Multivariable Optimization Approach
This study was performed to generate a protocol that improves development and quality of humanized mice in the BALB/c-Rag2nullIl2rγnull strain, testing route of injection, in vitro culture and freezing of human hematopoietic stem cells, types of cytokines in the culture, and co-injection of lineage-depleted CD34 cells. [Clin Immunol]

Effective Treatment of Severe Steroid-Resistant Acute Graft-Versus-Host Disease with Umbilical Cord-Derived Mesenchymal Stem Cells
Researchers compared umbilical cord-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells for morphology, surface markers expression, differentiation, proliferative potential, and their suppressive effects on peripheral blood mononuclear cell proliferation. [Transplantation]

CD34+ Cord Blood DC-Induced Antitumor Lymphoid Cells Have Efficacy in a Murine Xenograft Model of Human ALL
Researchers postulate that cytotoxic T lymphocytes generated from total RNA loaded cord blood CD34+-derived dendritic cells can control the kinetics of leukemic growth in a nonobese diabetic/severe combined immunodeficient mouse model of human acute lymphocytic leukemia (ALL). [J Immunother]

Paracrine Regulation of Megakaryo/Thrombopoiesis by Macrophages
The different stages of megakaryo/thrombopoiesis were analyzed by flow cytometry using an in vitro model of human cord blood CD34+ cells stimulated with thrombopoietin in either a transwell system or conditioned media from monocyte-derived macrophages isolated from peripheral blood. [Exp Hematol]

Allogeneic Cellular Gene Therapy in Hemoglobinopathies – Evaluation of Hematopoietic SCT in Sickle Cell Anemia
Data confirmed SCT from a suitable HLA-matched, related donor should become the primary option for curing children with sickle cell anemia. [Bone Marrow Transplant]

Use of a Precious Resource: Parental Decision Making About Using Autologous Umbilical Cord Blood in Studies Involving Young Children with Type 1 Diabetes
Researchers aimed to assess parental decision making and experiences in an autologous umbilical cord blood infusion study in young children with type 1 diabetes. [Contemp Clin Trials]

Quality Assessment of Umbilical Cord Blood Units at the Time of Transplantation
Researchers suggest that the total nucleated cell count and CD34+ cell content estimated before cryopreservation and in pre-transplant release tests provided by cord blood banks are reproducible and can assist the transplant physicians in selection of appropriate umbilical cord blood units. [Int J Hematol]

The Current Status of Umbilical Cord Blood Collection in Japanese Medical Centers: Survey of Obstetricians
The aim of this study was to reveal the current status of umbilical cord blood (UCB) collection and discuss the management of the UCB bank. [Transfus Apher Sci]

INDUSTRY NEWS
King’s Set to Join Scientific Powerhouse
King’s College London and Imperial College London are set to join the partners behind the world-leading medical research institute: the UK Centre for Medical Research and Innovation. [King’s College London Press Release]

Australian Rotarians Raise Money for Blood Bank
Rotarians have raised U.S. $6 million for a new cord blood bank in Perth, Western Australia, Australia, that will help patients facing life-threatening illnesses. [Rotary International Press Release]

Americord Registry Announces “Bank One, Give One” Cord Blood Program
Americord Registry announced a new program to assist families in need. Through the “Bank One, Give One” program, Americord will donate cord blood stem cell collection and storage services to select underprivileged families in the New York area for every new client who enrolls in Americord’s cord blood banking program during April and May 2011. [Americord Registry Press Release]

Cryo-Save India Set to Expand Cord Blood Banking Business to Rural Areas in North, Western Regions
Cryo-Save India, the largest adult stem cell and cord blood bank in the country is looking forward to expand its presence in the rural market. The company has already invested $ 3 million during the last two years and is now working out modalities to expand its foot print to north and western India. [PharmaBiz]
POLICY NEWS
Family Cord Blood Banking Act Introduced in 112th Congress
Legislation introduced by U.S. Representatives Wally Herger (R-CA) and Ron Kind (D-WI), called “The Family Cord Blood Banking Act,” would amend the IRS Code to allow individuals and couples to use flexible spending account, health savings account, health reimbursement arrangements or the medical expenses tax deduction to pay for umbilical cord blood banking services. [Congress, United States]

Senate Committee Approves Bill About Information on Umbilical Cord Blood
The Senate Health Committee approved a bill that would require the Missouri Health Department to share information about umbilical cord blood banking with pregnant women. [Missouri Senate Health Committee, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW 4th Stem Cells Europe
July 20-21, 2011
Edinburgh, Scotland

Visit our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Quality Assurance Manager – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Supervisor Cell Therapy Lab (The University of Texas MD Anderson Cancer Center)

INTERBIO-21st Project Coordinator (University of Oxford – Nuffield Department of Obstetrics & Gynaecology)

Senior Scientist (Matchtech)

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