Volume 3.20 | May 26

Cord Blood News 3.20, May 26, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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Reduced-Intensity Hematopoietic Cell Transplantation in Older Patients with AML/MDS: Umbilical Cord Blood is a Feasible Option for Patients without HLA-Matched Sibling Donors
Researchers compared outcomes of hematopoietic cell transplantation using HLA-matched sibling donors (N=38) or umbilical cord blood (N=60) among older patients (age 55 years) with AML or myelodysplastic syndromes (MDS). [Bone Marrow Transplant]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

ERG Promotes T-Acute Lymphoblastic Leukemia and is Transcriptionally Regulated in Leukemic Cells by a Stem Cell Enhancer
Here researchers demonstrate that transgenic expression of ERG causes T-acute lymphoblastic leukemia (T-ALL) in mice and that its knockdown reduces the proliferation of human MOLT4 T-ALL cells. [Blood]

Concise Review: Transplantation of Human Hematopoietic Cells for Extracellular Matrix Protein Deficiency in Epidermolysis Bullosa
How hematogenous stem cells from bone marrow and cord blood can alter skin architecture and wound healing in a robust, clinically meaningful way is unclear. Researchers review the data and the resulting hypotheses that have a potential to illuminate the mechanisms for these effects. [Stem Cells]

β2-Glycoprotein I and Protection from Anti-SSA/Ro60–Associated Cardiac Manifestations of Neonatal Lupus
In aggregate the data suggest that intact β2GPI in the fetal circulation may be a novel cardioprotective factor in anti-Ro60–exposed pregnancies. [J Immunol]

Mechanical Properties of Tissue-Engineered Vascular Constructs Produced Using Arterial or Venous Cells
The aim of the present study was to compare the mechanical properties of arterial and venous tissue-engineered vascular constructs produced by the self-assembly approach using cells extracted from either the artery or vein harvested from the same human umbilical cord. [Tissue Eng Part A]

Prenatally Harvested Cells for Cardiovascular Tissue Engineering: Fabrication of Autologous Implants Prior to Birth
Umbilical cord blood-, amniotic fluid- and chorionic villi-derived cells have shown promising potential for the clinical realization of this congenital tissue engineering approach. [Placenta]

Allogeneic Hematopoietic Stem Cell Transplantation for Advanced Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type
Here, researchers describe the clinical course of 12 cases of advanced and refractory ENKL treated with allo-HSCT, including five cases with cord blood transplant. [Leuk Lymphoma]

Copeptin Concentration in Cord Blood in Infants with Early-Onset Sepsis, Chorioamnionitis and Perinatal Asphyxia
The aim of this study was to establish copeptin concentrations in neonates of different stress states such as sepsis, chorioamnionitis and asphyxia. [BMC Pediatr]

Construction of Japanese BAC library Yamato-2 (JY2): a Set of 330K Clone Resources of Damage-Minimized DNA Taken from a Genetically Established Japanese Individual
A bacterial artificial chromosome (BAC) library referred to as Yamato-2 (JY2), was constructed from a Japanese individual and contained 330,000 clones. Library construction was based on 2 concepts: Japanese pedigree and non-immortalization. Genomic DNA was extracted from white blood cells from umbilical cord blood of a Japanese male individual. [Hum Cell]

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity
Previously, researchers demonstrated that umbilical cord blood (UCB) nTregs could be purified and expanded in vitro using good manufacturing practice reagents; however, the initial number of nTregs in UCB units is limited, and average yield after expansion was only 1 × 109 nTregs. Therefore, they asked whether yield could be increased by using peripheral blood, which contains far larger quantities of nTregs. [Sci Transl Med]



STEMSOFT® Software Inc. Launches Certified Partner Program
STEMSOFT Software Inc., the leading provider of software solutions for the cell therapy and transplant community, is pleased to announce the launch of a new Certified Partner Program. [STEMSOFT Software Inc. Press Release]

Maryland Stem Cell Research Commission Funds 36 New Projects in FY 2011
The Maryland Stem Cell Research Commission (Commission) has completed its review of the 180 applications received in response to its three FY 2011 Requests for Applications (RFAs). [Maryland Stem Cell Research Fund Press Release]

Cord Blood America First Quarter Revenues Up 74 Percent to $1.5 Million; U.S., Worldwide Storage of Stem Cells at Birth
Cord Blood America, Inc., announced that revenues for the first quarter of 2011, ended March 31, totaled $1.458 million, up 74 percent compared to revenues of $0.839 million in the same period in 2010. [Cord Blood America, Inc. Press Release]

Cryo-Cell International Shares Potentially Undervalued in Terms of Earnings Yield
Cryo-Cell International, Inc. announced that it was evaluated by SmarTrend as among the top five companies in the Health Care Services industry with the highest earnings yield. [GlobeNewswire]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW World Stem Cells & Regenerative Medicine Congress Asia 2011 
October 11-13, 2011 

Visit our events page to see a complete list of events in the cord blood community.

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Quality Assurance Manager – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Supervisor Cell Therapy Lab (The University of Texas MD Anderson Cancer Center)

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