Volume 3.22 | Jun 9

Cord Blood News 3.22, June 9, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

T Lymphocytes Derived from Human Cord Blood Provide Effective Antitumor Immunotherapy against a Human Tumor
The results show that cord blood derived T lymphocytes will be useful for novel immunotherapeutic candidate cells for therapy of several tumors in clinic. [BMC Cancer]

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SCIENCE NEWS
Stem Cell Treatment to Prevent Leukemia Returning Is a Step Closer
Researchers have identified a way of eliminating leukemic stem cells, which could in the future lead to new treatments that may enable complete remission for leukemia patients. [Press release from King’s College London discussing online prepublication in Cell Stem Cell]

Anschutz Medical Campus Researchers Discover New Process to Cultivate Adult Blood Cells
Scientists have developed a new method in which they use their proprietary blood stem-cell lines from cord blood to generate mature, adult red blood cells in the lab in 14 days. [The Denver Post]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Functional Crosstalk Between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells
In this study, scientists investigated whether leukemia-associated fusion proteins could initiate leukemia in the absence of Bmi1. [Cell Stem Cell]

Role of Slug Transcription Factor in Human Mesenchymal Stem Cells
Researchers used human mesenchymal stem cells from tibial plateau trabecular bone, iliac crest bone marrow and Wharton’s jelly umbilical cord demonstrating a variability in their mineral matrix deposition, and in the expression levels of transcription factors including Runx2, Sox9, Sox5, Sox6, STAT1 and Slug, all involved in the control of osteochondroprogenitors differentiation program. [J Cell Mol Med]

Stem Cell Course in the Middle East: Science Diplomacy and International Collaborations During the Arab Spring
In April 2011, an international advanced course and workshop entitled “Frontiers in Human Pluripotent Stem Cells” and an International Congress on Fertility and Genetics was held in Amman Jordan. A major emphasis was placed on the clinical achievements in germ cell and umbilical cord stem cell transplantation issues, and on the potential of fast and successful prenatal and pre-implantation molecular genetics diagnostics. [Stem Cell Rev]

Size-Sieved Subpopulations of Mesenchymal Stem Cells from Intervascular and Perivascular Equine Umbilical Cord Matrix
Umbilical cord matrix (UCM) has been recently proposed as an alternative source of mesenchymal stem cells (MSCs). The aim of this study was to isolate and characterize presumptive stem cells from intervascular and perivascular equine UCM and to obtain homogeneous subpopulations from both sites. [Cell Prolif]

Keratinocyte Growth Factor Enhanced Immune Reconstitution in Murine Allogeneic Umbilical Cord Blood Cell Transplant
Researchers hypothesized that keratinocyte growth factor (KGF) pre-administration would improve post-allogeneic umbilical cord blood transplant (allo-UCBT) thymopoiesis. To test this hypothesis, allo-UCBT recipient mice were given KGF or control saline prior to UCBT. [Leuk Lymphoma]

Characterization and Comparison of Telomere Length, Telomerase and Reverse Transcriptase Activity and Gene Expression in Human Mesenchymal Stem Cells and Cancer Cells of Various Origins
Rsearchers have characterized and compared the telomere length, telomerase, reverse transcriptase activity and expression of genes implicated in cancer and in pluripotency, in human mesenchymal stem cells (MSCs) derived from dental papilla tissue, umbilical cord matrix and adipose tissue and in cancer cells (MDA-MB-231, U-87 MG, and MCF-7). [Cell Tissue Res]

Sphingosine-1-Phosphate (S1P) Promotes the Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Cardiomyocytes Under the Designated Culturing Conditions
This study for the first time demonstrates that S1P potentiates differentiation of human umbilical cord mesenchymal stem cells towards functional cardiomyocytes under the designated culture conditions. [J Biomed Sci]

Investigation of the Effective Action Distance Between Hematopoietic Stem/Progenitor Cells and Human Adipose-Derived Stem Cells During Their In Vitro Co-culture
The in vitro suitable action distance between umbilical cord blood-derived hematopoietic stem/progenitor cells and its feeder cell, human adipose-derived stem cells, during their co-culture, was investigated through a novel transwell co-culture protocol, in which the distance between the two culture chambers where each cell type is growing can be adjusted from 10 to 450 μm. [Appl Biochem Biotechnol]

Transplantation of Human Umbilical Cord Blood Mesenchymal Stem Cells Improves Survival Rates in a Rat Model of Acute Hepatic Necrosis
Human umbilical cord blood mesenchymal stem cell (HUCBMSC) transplantation can significantly improve the survival of rats with acute hepatic necrosis. The underlying mechanisms involved may include the transdifferentiation of HUCBMSCs into hepatocyte-like cells and targeted migration of these cells to liver lesion sites. [Am J Med Sci]

INDUSTRY NEWS

Blood Stem Cell Bank to Provide Biological Insurance for Adults
Wealthy Britons can now pay to freeze and store their stem cells as an “insurance policy” that could be used to treat diseases they develop in the future or even grow new organs. [The Telegraph]

China Cord Blood Corporation to Report Fourth Quarter and Full Year Fiscal 2011 Financial Results
China Cord Blood Corporation announced its plan to release financial results for the fourth quarter and full year of fiscal year 2011 on Friday, June 10, 2011, after markets close in the US. [PR Newswire]

First Public Umbilical Cord Bank in the State Created by the Legislature
The state House of Representatives gave final legislative approval to a bill that establishes Connecticut’s first public umbilical cord blood bank. [The Hartford Courant]

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
Visit our events page to see a complete list of events in the cord blood community.
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