Volume 3.23 | Jun 16

Cord Blood News 3.23, June 16, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

Human Umbilical Cord Wharton’s Jelly Stem Cells Undergo Enhanced Chondrogenic Differentiation when Grown on Nanofibrous Scaffolds and in a Sequential Two-stage Culture Medium Environment
Researchers derived a unique stem cell from the human umbilical cord Wharton’s jelly that has properties superior to human bone marrow mesenchymal stem cells in terms of ready availability, prolonged stemness characteristics in vitro, high proliferation rates, wide multipotency, non-tumorigenicity and tolerance in allogeneic transplantation. [Stem Cell Rev]

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SCIENCE NEWS

Advantages of Cord Blood Stem Cell Transplantation Established
Since the first human cord blood transplant, performed in 1988, the safety and efficacy of umbilical cord blood transplantation in both children and adults with a variety of malignant and non-malignant diseases have been clearly established. [Press release from the European Hematology Association discussing research presented at the 16th Congress of the European Hematology Association in London]

Blood Simpler: Researchers Parse the Origins of Hematopoietic Stem Cells
Researchers have identified a gene and a novel signaling pathway, both critical for making the first hematopoietic stem cells in developing vertebrate embryos. [Press release from the University of California, San Diego Health System discussing online prepublication in Nature]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

A Somitic Wnt16/Notch Pathway Specifies Hematopoietic Stem Cells
Scientists demonstrated in zebrafish that Wnt16 controls a novel genetic regulatory network required for hematopoietic stem cells specification. [Nature]

A Switch Toward Angiostatic Gene Expression Impairs the Angiogenic Properties of Endothelial Progenitor Cells in Low Birth Weight Pre-Term Infants
Researchers investigate whether low birth weight alters the angiogenic properties of cord blood endothelial colony forming cells in 25 preterm neonates compared to 25 term neonates. [Blood]

GATA3 Is Redundant for Maintenance and Self-Renewal of Hematopoietic Stem Cells
Scientists used a conditional Gata3 knockout strategy in which Gata3 expression was completely deleted from the earliest stage of embryonic hematopoietic development after emergence of hematopoietic stem cells from hemogenic endothelium. [Blood]

Long-Term Outcome and Lineage-Specific Chimerism in 194 Wiskott-Aldrich Syndrome Patients Treated by Hematopoietic Cell Transplantation Between 1980–2009: An International Collaborative Study
In this retrospective collaborative study, investigators have analyzed long-term outcome and donor cell engraftment in 194 patients with the Wiskott-Aldrich syndrome who have been treated by hematopoietic cell transplantation in the period 1980-2009. [Blood]

Atypical Protein Kinase C (aPKCζ and aPKCλ) Is Dispensable for Mammalian Hematopoietic Stem Cell Activity and Blood Formation
Investigators report that, in contrast to accepted paradigms, polarization and activity of adult hematopoietic stem cells do not depend on either aPKCζ or aPKCλ or both in vivo. [Proc Natl Acad Sci U S A]

Determination of Glycated and Acetylated Hemoglobins in Cord Blood by Time-of-Flight Mass Spectrometry
Researchers developed and validated a method using electrospray time-of-flight mass spectrometry that measures, in a single analysis, relative levels of glycated and acetylated hemoglobin and allows the calculation of relative proportions of hemoglobin A, hemoglobin F0, and hemoglobin F1 in cord blood. [Anal Chem]

Cord Blood Transplantation from Unrelated Donors for Children with Acute Lymphoblastic Leukemia in Japan: The Impact of Methotrexate on Clinical Outcomes
Researchers analyzed the clinical outcomes of cord blood transplantation for children with acute lymphoblastic leukemia in Japan and identified the risk factors for the transplant outcomes. [Biol Blood Marrow Transplant]

Differential Mechanisms of X-Ray-Induced Cell Death in Human Endothelial Progenitor Cells Isolated from Cord Blood and Adults
To begin to characterize the potential role of endothelial colony-forming cells (ECFCs) during the treatment of tumors in children and adults with radiation, researchers characterized the X-ray sensitivity of cord and adult blood-derived ECFCs. [Radiat Res]

Clinical Observations on Intensive Immunosuppressive Therapy Combined with Umbilical Cord Blood Support for the Treatment of Severe Aplastic Anemia
The objective was to evaluate the efficacy of enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support for severe aplastic anemia. [J Hematol Oncol]

INDUSTRY NEWS

ThermoGenesis Announces Webcast of Presentation at OnemedForum Conference
ThermoGenesis Corp., a leading supplier of innovative products and services that process and store adult stem cells, said it will be participating in the OnemedForumNY 2011 Conference on Thursday, June 23. [PR Newswire]

China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2011
China Cord Blood Corporation, China’s leading provider of cord blood collection, laboratory testing, hematopoietic stem cell processing, and stem cell storage services, announced preliminary unaudited financial results for the fourth quarter and fiscal year of 2011, which ended March 31, 2011. [China Cord Blood Corporation Press Release]

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW European School of Hematology – European Hematology Association Scientific Workshop: Acute Myeloid Leukemia “Molecular”
October 14-16, 2011
Madndelieu, France

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

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Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Supervisor Cell Therapy Lab (The University of Texas MD Anderson Cancer Center)

Chemist (STEMCELL Technologies) 

Research and Development Senior Technologist (STEMCELL Technologies)

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