Volume 3.25 | Jun 30

Cord Blood News 3.25, June 30, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

Clinical-Grade Generation of Active NK Cells from Cord Blood Hematopoietic Progenitor Cells for Immunotherapy Using a Closed-System Culture Process
Researchers translated our cytokine-based culture protocol for ex vivo expansion of natural killer (NK) cells from umbilical cord blood hematopoietic stem cells into a fully closed, large-scale, cell culture bioprocess. [PLoS One]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Higher Cord C-Peptide Concentrations Are Associated With Slower Growth Rate in the 1st Year of Life in Girls but Not in Boys
The objective was to understand the relationships between maternal glycemia during pregnancy and prenatal and early postnatal growth by evaluating cord C-peptide and IGF-I as mediating biomarkers in boys and girls separately. [Diabetes]

The Inhibition Effect of Anti-GPIIIa49–66 Antibody on Megakaryocyte Differentiation
Since the megakaryocyte (MK) is the progenitor cell for platelets, researchers have investigated the effect of anti-GPIIIa49–66 on MK differentiation and, in particular, the potential role of anti-GPIIIa49–66 induced reactive oxygen species in this process. [Thromb Haemost]

Transformation of Human Mesenchymal Cells and Skin Fibroblasts into Hematopoietic Cells
To determine whether nonhematopoietic cells can be reprogrammed into hematopoietic cells, human mesenchymal stromal cells and skin fibroblasts were incubated with the demethylating agent 5-azacytidine and the growth factors granulocyte-macrophage colony-stimulating factor and stem cell factor. [PLoS One]

CD133 Positive Progenitor Endothelial Cell Lines from Human Cord Blood
The aim of the study was the immortalization of early progenitor cells with high proliferative potential, capable to differentiate to endothelial progenitor cells and, further, toward endothelial cells. [Cytometry A]

Intrapulmonary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Attenuates Acute Lung Injury by Expanding CD4+CD25+ Forkhead Boxp3 (FOXP3)+ Regulatory T Cells and Balancing Anti- and Pro-inflammatory Factors
The present study was designed to determine whether human umbilical cord mesenchymal stem cells are able to act on CD4+CD25+ Foxp3+ regulatory T cells and lead to an improvement in acute lung injury. [Cell Physiol Biochem]

The Effect of Human Fetal Liver-Derived Mesenchymal Stem Cells on CD34+ Hematopoietic Stem Cell Repopulation in NOD/Shi-scid/IL-2Rγnull Mice
Researchers optimized culture conditions for human fetal liver-derived mesenchymal stem cells (hFL-MSCs) to investigate the role of hFL-MSCs on repopulation of hematopoietic stem cells in NOD/Shi-scid/IL-2Rγnull mice using CD34+ hematopoietic stem cells derived from umbilical cord blood. [Transplant Proc]

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INDUSTRY NEWS

July is Cord Blood Awareness Month
Cord Blood Awareness Month is sponsored by a society of the American Hospital Association and strives to empower expectant parents to make an informed choice regarding their options to save their newborn’s cord blood stem cells. [Cord Blood Registry Press Release]

Cord Blood America Enters Agreement With Horizon Healthcare Services, Inc. to Offer Stem Cell Collection Services to Its Members
Cord Blood America, Inc. announced it has entered into agreement with Horizon Healthcare Services, Inc., to offer the storage of umbilical cord blood to its members. [Cord Blood America Inc. Press Release]

StemCyte – An Industry Leader Introduces Dual Cord Blood Processing Capabilities
California-based StemCyte, Inc. continues its innovative leadership in cord blood banking and cell therapies with the announcement of Dual Processing Capabilities using the Sepax automation system from Biosafe. [PR Newswire]

FamilyCord Introduces CordTissuePlus
FamilyCord announced their latest contribution to the advancement of the umbilical cord blood and tissue storage industry: CordTissuePlus. [PR Newswire]

Golden Meditech to Increase Stake in NYSE-listed Affiliate – China Cord Blood Corporation to 39.5%
Golden Meditech Holdings Limited announced that the Group has accumulated 754,791 ordinary shares in its NYSE-listed affiliate, China Cord Blood Corporation from the open market between December 2010 and March 2011. [PR Newswire]

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW 4th Stem Cells Europe
July 20-21, 2011
Edinburgh, United Kingdom

NEW Cancer Research Global Summit
August 16-17, 2011
London, United Kingdom

NEW The EMBO Meeting 2011
September 10-13, 2011
Vienna, Austria

Visit
our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (Maternity Leave) (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Chemist (STEMCELL Technologies) 

Research and Development Senior Technologist (STEMCELL Technologies)

Quality Assurance Manager – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Supervisor Cell Therapy Lab (The University of Texas MD Anderson Cancer Center)

Industrial Postdoctoral Research Fellow (Regenerative Medicine Cell Therapy) (Tissue Regeneration Therapeutics Inc.) 

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