Volume 3.31 | Aug 11

Cord Blood News 3.31, August 11, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Efficient Generation of Transgene-Free Human Induced Pluripotent Stem Cells (iPSCs) by Temperature-Sensitive Sendai Virus Vectors
Here investigators show that Sendai virus vector is a practical solution for the efficient generation of safer iPSCs. Using these vectors enabled the efficient production of viral/factor-free iPSCs from both human fibroblasts and CD34+ cord blood cells. [Proc Nat Acad Sci USA]

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SCIENCE NEWS

Researchers Find Way to Help Donor Adult Blood Stem Cells Overcome Transplant Rejection
Findings by researchers may suggest new strategies for successful donor adult stem cell transplants in patients with blood cancers such as leukemia, lymphoma and myeloma. [Press release from The University of Texas Southwestern Medical Center discussing online prepublication in Cell Stem Cell]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Ex Vivo Expanded Hematopoietic Stem Cells Overcome the MHC Barrier in Allogeneic Transplantation
Here researchers show that ex vivo expanded mouse hematopoietic stem cells efficiently overcame the major histocompatibility complex barrier and repopulated allogeneic-recipient mice. [Cell Stem Cell]

Arsenic Disulfide Synergizes with the Phosphoinositide 3-Kinase Inhibitor PI-103 to Eradicate Acute Myeloid Leukemia Stem Cells by Inducing Differentiation
In the present study, PI3K/AKT/mTOR phosphorylation was strengthened after As2S2 exposure in leukemia cell lines and stem/progenitor cells, but not in cord blood mononuclear cells. [Carcinogenesis]

Exposure to Moderate Air Pollution During Late Pregnancy and Cord Blood Cytokine Secretion in Healthy Neonates
The results suggest that even naturally occurring prenatal exposure to moderate amounts of indoor and outdoor air pollution may lead to changes in cord blood cytokine levels in a population based cohort. [PLoS One]

MicroRNA-96 Directly Inhibits γ-Globin Expression in Human Erythropoiesis
Comparing microRNA (miRNA) expression in reticulocytes from cord blood and adult blood, researchers identified several miRNAs that were preferentially expressed in adults, among them miRNA-96. [PLoS One]

Hematopoietic Stem-Cell Transplantation Following Solid-Organ Transplantation in Children
Researchers report herein the outcomes of all our pediatric recipients of allogeneic hematopoietic stem-cell transplantation following previous solid-organ transplantation between 2000 and 2009. [Bone Marrow Transplant]

The Effect of Maternal Number of Births on Oxidative and Antioxidative Systems in Cord Blood
The aim of this study was to evaluate the relationship between cord blood oxidative and antioxidative status and maternal parity number. [J Matern Fetal Neonatal Med]

The Effect of Time, Temperature and Storage Device on Umbilical Cord Blood Gas and Lactate Measurement: A Randomized Controlled Trial
This study evaluates the impact of time, temperature and method of storage on umbilical blood gas and lactate analyses. [J Matern Fetal Neonatal Med]

INDUSTRY NEWS

Cryo-Cell Evaluates Strategic Alternatives Including Potential Sale
Cryo-Cell International, Inc. announced that the Executive Committee of its Board of Directors has authorized the Company’s management and financial advisors to explore strategic alternatives to enhance shareholder value, including a possible sale of the Company. [Cryo-Cell International, Inc. Press Release]

Lifeforce Cryobanks Launches New Identity Campaign to Help Communicate Full Spectrum of Services Offered by Cord Blood Bank and Demonstrate Lifesaving Potential of Umbilical Cord Blood
Lifeforce Cryobanks has launched a new identity campaign created by L2 Inc. [Lifeforce Cryobanks Press Release]

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW 4th Annual Maryland Stem Cell Research Symposium
October 6, 2011
Towson, United States

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Cord Blood Procurement Specialist (Karmanos Cancer Institute)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

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