Volume 3.33 | Aug 25

Cord Blood News 3.33, August 25, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

A Comparison of Immune Reconstitution and Graft-Versus-Host Disease Following Myeloablative Conditioning Versus Reduced Toxicity Conditioning and Umbilical Cord Blood Transplantation in Pediatric Recipients
In 88 consecutive pediatric recipients of umbilical cord blood transplantation, researchers assessed immune cell recovery and immunoglobulin reconstitution at days +100, 180 and 365 and analyzed risk factors associated with acute and chronic graft-versus-host disease. [Br J Haematol]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Immunological Applications of Stem Cells in Type 1 Diabetes
Cord blood stem cells have been shown to facilitate the generation of regulatory T cells, thereby reverting hyperglycemia in nonobese diabetic mice. [Endocr Rev]

Hematopoietic Cells as Sources for Patient-Specific iPSCs and Disease Modeling
Here researchers describe the recent advances in generating disease specific human induced pluripotent stem cells (iPSCs) from the different types of hematopoietic cells and their potential applications in disease modeling and regenerative medicine. [Cell Cycle]

Mesenchymal Stem Cells Inhibit Thymic Reconstitution After Allogeneic Cord Blood Transplantation
The results highlight the importance of close monitoring of the immune reconstitution after cord blood transplantation. In addition it shows a potentially new suppressive effect of mesenchymal stem cells on the immune system. [Stem Cells Dev]

Collagen-Calcium Phosphate Cement Scaffolds Seeded with Umbilical Cord Stem Cells for Bone Tissue Engineering
The objectives of this study were to develop a novel class of collagen-calcium phosphate cement (CPC) composite scaffolds, and to investigate human umbilical cord mesenchymal stem cell attachment, proliferation, and osteogenic differentiation on collagen-CPC scaffolds for the first time. [Tissue Eng Part A]

Successful In Vitro Expansion and Differentiation of Cord Blood Derived CD34+ Cells into Early Endothelial Progenitor Cells Reveals Highly Differential Gene Expression
Herein, investigators describe an in vitro culture technique with the aim to generate high numbers of phenotypically, functionally and genetically defined early endothelial progenitor cells from human cord blood. [PLoS One]

Intra-Bone Marrow Transplantation of Unwashed Cord Blood Using Reduced-Intensity Conditioning Treatment: A Phase I Study
Researchers found that intra-bone marrow injection of unwashed cord blood following reduced-intensity conditioning is safe, well tolerated, and may lead to an increased donor engraftment rate. [Biol Blood Marrow Transplant]

Long-Term Follow-Up of Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia: Impact of Tyrosine Kinase Inhibitors on Treatment Outcomes
A retrospective analysis was conducted on 102 adults and 11 children who received a first matched related (n=60), matched unrelated (n=40), mismatched cord blood (n=12), or haplo-identical (n=1) allogeneic hematopoietic stem cell transplant for Philadelphia chromosome positive acute lymphoblastic leukemia in first complete remission (n=71), second complete remission (n=11) or with active disease (n=31) between 1990 and 2009. [Biol Blood Marrow Transplant]

A Novel Method for Human Hematopoietic Stem/Progenitor Cell Isolation from Umbilical Cord Blood Based on Immunoaffinity Aqueous Two-Phase Partitioning
A novel cell separation process based on immunoaffinity aqueous two phase systems is presented to isolate and purify CD34+ stem/progenitor cells directly from the whole umbilical cord blood. [Biotechnol Lett]

Transplantation of Human Umbilical Cord Blood Mesenchymal Stem Cells Improves Survival Rates in a Rat Model of Acute Hepatic Necrosis
This study aimed to evaluate the effects of human umbilical cord blood mesenchymal stem cell transplantation in acute hepatic necrosis. [Am J Med Sci]

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INDUSTRY NEWS

Cord Blood America Enters Major Agreement to Provide Storage Services in Washington and Alaska
Cord Blood America, Inc. announced that it has entered into an agreement with Premera Blue Cross to store umbilical cord blood at a discounted rate consistent with other Blue Cross licensee contracts. [Cord Blood America, Inc. Press Release]

Cryo-Save Group N.V. – Solid Half Year Results
Cryo-Save Group N.V. has published its financial results for the six months ended 30 June 2011. [Cryo-Save Group N.V. Press Release]

China Cord Blood Corporation to Report First Quarter Fiscal 2012 Financial Results
China Cord Blood Corporation announced its plan to release financial results for the first quarter of fiscal year 2012 on Monday, August 29, 2011, after market close in the US. [China Cord Blood Corporation Press Release]

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POLICY NEWS

International Program Expands Efforts to Improve Blood Transfusion Safety
The National Heart, Lung, and Blood Institute of the National Institutes of Health has launched an $87.2 million international research
program to extend a highly successful program assessing blood banking and transfusion medicine. [National Heart, Lung, and Blood Institute, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 5th Advances in Stem Cell Discovery and Development
October 19-21, 2011
San Diego, United States

Visit our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 

Research and Development Technologist (STEMCELL Technologies) 

Cord Blood Procurement Specialist (Karmanos Cancer Institute)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

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