Volume 3.34 | Sep 1

Cord Blood News 3.34, September 1, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Cord Colitis Syndrome in Cord-Blood Stem-Cell Transplantation
After the transplantation and engraftment of hematopoietic stem cells from umbilical-cord blood, researchers observed a new syndrome of culture-negative, antibiotic-responsive diarrhea not attributable to any known cause. [N Engl J Med] Abstract | Press Release

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Risk Factors Associated with Increased Non-Relapse Mortality and with Poor Overall Survival in Children with Chronic Graft-Versus-Host Disease
Researchers performed multivariate analyses to identify risk factors for non-relapse mortality and survival in 1117 pediatric subjects with leukemia or myelodysplastic syndrome, transplanted from related donors, unrelated donors or unrelated cord blood between 1995-2004. [Blood] Abstract

Ontogeny Stage-Independent and High-Level Clonal Expansion In Vitro of Mouse Hematopoietic Stem Cells Stimulated by an Engineered NUP98-HOX Fusion Transcription Factor
The findings point to the effects of NUP98-HOXA10hd on hematopoietic stem cells in vitro being mediated by promoting self-renewal and set the stage for further dissection of this process. [Blood] Abstract

Core–Shell Cell Bodies Composed of Human cbMSCs and HUVECs for Functional Vasculogenesis
In the study, researchers used a thermo-responsive hydrogel system to fabricate core–shell cell bodies composed of cord-blood mesenchymal stem cells (cbMSCs) and human umbilical vascular endothelial cells (HUVECs) for functional vasculogenesis. [Biomaterials] Abstract

Very Small Embryonic-Like Stem Cells with Maximum Regenerative Potential Get Discarded During Cord Blood Banking and Bone Marrow Processing for Autologous Stem Cell Therapy
Very small embryonic-like stem cells are possibly lost during cord blood banking and bone marrow (BM) processing for autologus stem cell therapy mainly because of their small size. The present study was conducted on human umbilical cord blood and discarded red blood cells fraction obtained after separation of mononuclear cells from human BM, to test this hypothesis. [Stem Cells Dev] Abstract

MicroRNA and Messenger RNA Analyses of Mesenchymal Stem Cells Derived from Teeth and the Wharton Jelly of Umbilical Cord
This study has integrated the use of microRNA and messenger RNA expression profiles to analyze human mesenchymal stem cells derived from Wharton’s jelly of the umbilical cord, milk teeth, and adult wisdom teeth. [Stem Cells Dev] Abstract

Immune Reconstitution After Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation
To define the differences in immune reconstitution between double umbilical cord blood (DUCB) transplantation and human leukocyte antigen-matched unrelated donor transplantation, researchers performed a detailed, prospective analysis of immune reconstitution in 42 DUCB recipients and 102 filgrastim-mobilized unrelated peripheral blood stem cell recipients. [Biol Blood Marrow Transplant] Abstract

The Saudi Experience in Fludarabine-Based Conditioning Regimens for Fanconi Anemia Patients Undergoing Stem Cell Transplantation: Excellent Outcome in Recipients of Matched Related Stem Cells but Not in Recipients of Unrelated Cord Blood Stem Cells
Scientists conclude that the combination of cyclophosphamide, fludarabine, and antithymocyte globulin in the doses used in this study is well tolerated, and that the proclaimed positive effect of adding flu to the conditioning regimens of Fanconi anemia patients is most pronounced in recipients of HLA-matched related stem cell transplantation. [Biol Blood Marrow Transplant] Abstract

Cell Recovery Comparison Between Plasma Depletion/Reduction- and Red Cell Reduction-Processing of Umbilical Cord Blood
The data indicates that plasma depletion/reduction processing of cord blood provides a significantly more efficient usage of this valuable and scarce resource. [Cytotherapy] Abstract

A Cross-Sectional Study of Umbilical Cord Blood Donor Profiles and Their Influence on Umbilical Cord Blood Collection in a Brazilian Hospital
The aim was to describe the donor population and assess the best cord blood collection technique at Hospital Israelita Albert Einstein’s cord blood bank (São Paulo, Brazil). [Cytotherapy] Abstract

Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy
In this study researchers show that umbilical cord blood-derived CD14+ progenitor cells provide rescue effects in a mouse model of ischemic retinopathy by promoting physiological angiogenesis and reducing associated inflammation. [Sci Rep] Abstract

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INDUSTRY NEWS

CIRM Commits $1.8 Million to Build Stem Cell Teams, Accelerate New Therapies
The California Institute for Regenerative Medicine approved funding $1.8 million to support 19 researchers in their effort to assemble competitive teams to develop applications for the Disease Team Therapy Development Awards, which will be due in winter 2012. [The California Institute for Regenerative Medicine] Press Release

Cord Blood America Now Banking Stem Cells in Puerto Rico, the Caribbean
Cord Blood America, Inc. announced it has entered into an agreement with BancoVida to offer umbilical cord blood collection services in Puerto Rico and throughout the Caribbean. [Cord Blood America, Inc.] Press Release

China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012
China Cord Blood Corporation announced its preliminary unaudited financial results for the first quarter of fiscal year 2012, which ended June 30, 2011. [China Cord Blood Corporation] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW The New York Stem Cell Foundation Sixth Annual Translational Stem Cell Research Conference
October 11-12, 2011
New York, United States

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 

Research and Development Technologist (STEMCELL Technologies) 

Cord Blood Procurement Specialist (Karmanos Cancer Institute)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

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