Volume 3.36 | Sep 15

Cord Blood News 3.36, September 15, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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Long-Term Cytokine-Free Expansion of Cord Blood Mononuclear Cells in Three-Dimensional Scaffolds
In order to derive a cytokine-free dynamic culture system, investigators hypothesised that a three-dimensional environment in the form of highly porous scaffolds made of poly (D,L-lactide-co-glycolide) or polyurethane for the biomimetic growth of cord blood mononuclear cells, would facilitate expansion of hematopoietic cells without exogenous cytokines. [Biomaterials] Abstract


PUBLICATIONS (Ranked by Impact Factor of the Journal)

Polymorphisms in Genes That Regulate Cyclosporine Metabolism Affect Cyclosporine Blood Levels and Clinical Outcomes in Patients Who Receive Allogeneic Hematopoietic Stem Cell Transplantation
In patients who received allogeneic hematopoietic stem cell transplantation, researchers investigated the correlations between single nucleotide polymorphisms in genes that regulate cyclosporine metabolism and clinical outcomes. [Blood] Abstract

Significant Clinical, Neuropathological and Behavioural Recovery from Acute Spinal Cord Trauma by Transplantation of a Well-Defined Somatic Stem Cell from Human Umbilical Cord Blood
Here, researchers have transplanted a well-defined unrestricted somatic stem cell isolated from human umbilical cord blood into an acute traumatic spinal cord injury of adult immune suppressed rat. [Brain] Abstract

Neurogenic Properties and a Clinical Relevance of Multipotent Stem Cells Derived from Cord Blood Samples Stored in the Biobanks
Scientists showed in this study that multipotent stem cells derived from fresh and frozen cord blood samples could be efficiently induced in defined serum-free medium toward neuronal progenitors (NF200+, Ki67+). [Stem Cells Dev] Abstract

Therapeutic Efficacy of Cord Blood-Derived Mesenchymal Stromal Cells for the Prevention of Acute GVHD in a Xenogenic Mouse Model
Here, researchers tested the ability of cord blood-derived mesenchymal stromal cells to alleviate the symptoms of graft-versus-host disease induced by the injection of human peripheral blood mononuclear cells into NOD/SCID/γc- mice. [Stem Cells Dev] Abstract

Combination of Low O2 Concentration and Mesenchymal Stromal Cells During Culture of Cord Blood CD34+ Cells Improves the Maintenance and Proliferative Capacity of Hematopoietic Stem Cells
The data demonstrate that association of co-culture and low O2 concentration not only induces sufficient expansion of committed progenitors (with respect to the classical culture), but also ensures a better maintenance/expansion of hematopoietic stem cells, pointing to the oxygenation as a physiological regulatory factor but also as a cell engineering tool. [J Cell Physiol] Abstract

Recurrence of Monoclonal Gammopathy Associated with Donor-Derived Myelodysplastic Syndrome After Cord Blood Stem Cell Transplantation
Investigators report a patient who developed donor-derived myelodysplastic syndrome (MDS) followed by leukemic transformation after cord blood transplantation for MDS with monoclonal gammopathy. [Exp Hematol] Abstract

Profiling of Immune-Related MicroRNA Expression in Human Cord Blood and Adult Peripheral Blood Cells Upon Proinflammatory Stimulation
The aim was to elucidate the molecular mechanism underlying the immune response of cord blood (CB)-derived cells during acute graft-versus-host disease and infection following CB transplantation. [Eur J Haematol] Abstract

In Vitro Effects of Stromal Cells Expressing Different Levels of Jagged-1 and Delta-1 on the Growth of Primitive and Intermediate CD34+ Cell Subsets from Human Cord Blood
Researchers assessed the effects of the OP9 stroma cell line – naturally expressing Jagged-1 – transduced with either the Delta-1 gene (OP9-DL1 cells) or with vector alone (OP9-V), on the in vitro growth of two different hematopoietic cell populations. [Blood Cells Mol Dis] Abstract

Ex Vivo Differentiation of Natural Killer Cells from Human Umbilical Cord Blood CD34+ Progenitor Cells
Researchers have explored the capacities of natural killer-cells after differentiation from hematopoietic stem and progenitor cells derived from human umbilical cord blood. [Cell Commun Adhes] Abstract



Cryo-Save Opens New Stem Cell Lab in Cape Town
Cryo-Save South Africa is pleased to announce the opening of its state-of-the-art stem cell processing and storage laboratory in Cape Town, South Africa. [Cryo-Save AG] Press Release

Russia’s Human Stem Cell Institute and the UK’s Xenetic Biosciences Explore Joint Projects in the International Biotech Sector
Human Stem Cell Institute and Xenetic Biosciences met to discuss opportunities for further collaboration and investment in the international biotech sector. [PR Newswire] Press Release

Newborn Possibilities Fund Awards Grant to Memorial Hermann Foundation to Support Groundbreaking Pediatric Research
The UTHealth Medical School is conducting an innovative FDA-regulated clinical trial evaluating the use of a child’s own cord blood stem cells as a potential medical intervention for traumatic brain injury. [PR Newswire] Press Release


Chinese Science Ministry Increases Funding
The Chinese Ministry of Science and Technology unveiled a list of 64 research projects to be funded under the sixth round of its annual
National Major Scientific Research Program. [Chinese Ministry of Science and Technology] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Stem Cells in Drug Discovery and Development
November 2-3, 2011
La Jolla, United States

Visit our events page to see a complete list of events in the cord blood community.

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 

Research and Development Technologist (STEMCELL Technologies) 

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

Postdoctoral Position (Izmir Katip Celebi University)

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