Volume 3.37 | Sep 22

Cord Blood News 3.37, September 22, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Intensive Strategy to Prevent Cytomegalovirus Disease in Seropositive Umbilical Cord Blood Transplant Recipients
Researchers found that use of an intensive CMV prevention strategy in high-risk CMV seropositive umbilical cord blood transplant recipients results in a significant decrease in CMV reactivation and disease. [Blood] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Methionine Aminopeptidase 2 Is Required for Hematopoietic Stem Cell Initiation and Proliferation
Researchers investigated the role of methionine aminopeptidase II in hematopoiesis using zebrafish embryo and human umbilical cord blood models. [Blood] Abstract

HLA-Targeted Flow Cytometric Sorting of Blood Cells Allows Separation of Pure and Viable Microchimeric Cell Populations
Investigators demonstrate applicability of HLA-targeted FACS sorting after pregnancy by separating chimeric maternal cells from child umbilical cord mononuclear cells. [Blood] Abstract

Crucial Role of Nuclear Ago2 for hUCB-MSCs Differentiation and Self-Renewal via Stemness Control
In this study, researchers demonstrate novel functions and molecular mechanisms of nuclear Argonaute2 (Ago2) in the self-renewal and plasticity of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs). [Antioxid Redox Signal] Abstract

Assessment of Neuroprotective Effects of Human Umbilical Cord Blood Mononuclear Cell Subpopulations In Vitro and In Vivo
The study suggests that mononuclear cells (MNCs) provide the most prominent neuroprotective effect with CD34+ cells seeming to be particularly involved in the protective action of MNCs. [Cell Transplant] Abstract

Predifferentiated Human Committed T-Lymphoid Progenitors Promote Peripheral T-Cell Reconstitution After Stem Cell Transplantation in Immunodeficient Mice
Here, researchers analysed the developmental potential of human peripheral blood CD34+ HSCs compared with committed T/NK-lymphoid progenitors from a third-party donor in a murine NOD-scid IL2Rnull model of humanized chimeric haematopoiesis. [Eur J Immunol] Abstract

The i Blood Group Antigen as a Marker for Umbilical Cord Blood Derived Mesenchymal Stem Cells
Researchers used flow cytometry and mass spectrometric glycan analysis and discovered that linear poly-N-acetyllactosamine structures are expressed in umbilical cord blood derived mesenchymal stem cells, but not in cells differentiated from them. [Stem Cells Dev] Abstract

Transcriptional Repression of Mad-Max Complex by Human Umbilical Cord Blood Stem Cells Downregulates ERK in Glioblastoma
To study the cell cycle progression and investigate the upstream molecules regulating cyclin D1 expression, researchers analyzed the involvement of ERK and its functionality after treatment with hUCBSC. [Stem Cells Dev] Abstract

Ex Vivo Expansion of Human Hematopoietic Stem Cells by Garcinol, a Potent Inhibitor of Histone Acetyltransferase
In this study, scientists screened biologically active natural products for activity to promote expansion of human cord blood (hCB) hematopoietic stem and progenitor cells (HSCs/PCs) ex vivo, and identified Garcinol, a plant-derived histone acetyltransferase inhibitor, as a novel stimulator of hCB HSC/PC expansion. [PLoS One] Abstract

Cord Blood CD4+ T Cells Respond to Self Heat Shock Protein 60 (HSP60)
Investigators studied whether self-HSP60 reactive T cells are present in cord blood, and if so, what phenotype these cells have. [PLoS One] Abstract

Pre-Engraftment Syndrome After Unrelated Donor Umbilical Cord Blood Transplantation in Patients with Hematologic Malignancies
Researchers retrospectively analyzed the incidence, risk factors, manifestations, and clinical outcomes of pre-engraftment syndrome in umbilical cord blood transplantation recipients, who had been treated for hematological malignancies at a transplantation center. [Eur J Haematol] Abstract

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INDUSTRY NEWS

Cellerant Therapeutics Awarded Additional $16.7 Million Under Existing US Government Contract to Fund Development of CLT-008 for Acute Radiation Syndrome
Cellerant Therapeutics Inc. announced that it has been awarded additional funding valued at $16.7 million by the Biomedical Advanced Research and Development Authority in the Office of the Assistant Secretary for Preparedness and Response of the Department of Health and Human Services, for the advanced development of CLT-008, a first-in-class, allogeneic, cell-based therapy for the treatment of Acute Radiation Syndrome. [Cellerant Therapeutics Inc.] Press Release

Cord Blood America Laboratory Update
Cord Blood America, Inc. announced that it has received all State licenses and Federal registrations required to operate as a cord blood bank in the United States. [Cord Blood America, Inc.] Press Release

Three U-M Researchers Named 2011 MacArthur Fellows
Three University of Michigan researchers—a historian, a chemist and a stem cell biologist—are among the 22 new MacArthur Fellows announced by the John D. and Catherine T. MacArthur Foundation. [University of Michigan] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 6th Annual Congress of the German Society for Stem Cell Research
November 20-22, 2011
Duesseldorf, Germany

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 

Research and Development Technologist (STEMCELL Technologies) 

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

Postdoctoral Position (Izmir Katip Celebi University)

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