Volume 3.28 | Jul 21

Cord Blood News 3.28, July 21, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation
Here, researchers report that acute myelogenous leukemia (AML)1-ETO, the fusion protein generated by the t(8;21), is acetylated by p300 in leukemia cells isolated from t(8;21) AML patients and is essential for its self-renewal promoting effects in human cord blood CD34+ cells and its leukemogenicity in mouse models. [Science]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

NK-Cell Education After Allogeneic Transplantation: Dissociation Between Recovery of Cytokine Producing and Cytotoxic Functions
Researchers tested the cytokine production and degranulation of reconstituting Natural Killer (NK) cells after adult unrelated donor or umbilical cord blood grafting. [Blood]

Successful Mobilization and Engraftment of Peripheral Blood Stem Cells Derived from Donor Cord Blood Cells After a Previous Allogeneic RIC Single Unrelated Cord Blood Transplantation
Researchers describe a successful salvage treatment with intensive chemotherapy and stem cell transplantation for a relapse of Hodgkin lymphoma after single umbilical cord blood transplantation with a reduced intensity-conditioning regimen (RIC). [Blood]

Hematopoietic Stem Cell Transplantation for CD3δ Deficiency
Researchers’ objectives were to study the outcome of CD3δ deficiency by using various modalities of stem cell transplantation. [J Allergy Clin Immunol]

Progesterone Promotes Differentiation of Human Cord Blood Fetal T Cells into T Regulatory Cells but Suppresses Their Differentiation into Th17 Cells
Researchers report in this work a novel function of progesterone in regulation of naive cord blood fetal T cell differentiation into key T regulatory cell subsets. [J Immunol]

Histone Deacetylase Inhibition Enhances Self Renewal and Cardioprotection by Human Cord Blood-Derived CD34+ Cells
Results show that histone deacetylase blockade leads to phenotype changes in CD34+ cells with enhanced self renewal and cardioprotection. [PLoS One]

Stem-Cell Therapy for Peripheral Arterial Occlusive Disease
The aims of this study were to confirm the effectiveness via animal study and safety through clinical trials of using human cord blood-mononuclear cells. [Eur J Vasc Endovasc Surg]

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INDUSTRY NEWS

Americord Registry Announces Appointment of New Cord Blood Banking Medical Director
Americord Registry is proud to announce the appointment of a new Executive Medical Director, Dr. Robert Dracker. [Americord Registry Press Release]

Statewide Cord Blood Bank Celebrates Grand Opening at UAMS
Michele Fox, M.D., director of cell therapy and transfusion medicine at the University of Arkansas Medical Sciences (UAMS) and medical director of the Cord Blood Bank, has led an effort to make Arkansas the first statewide-coverage cord blood bank in the nation to open with a mandate for public, private and research banking. [University of Arkansas Medical Sciences]

Cord Blood America Launches Major New Referral Program
Cord Blood America, Inc. announced that CorCell has a launched a new Referral Rewards Program in the U.S. for the collection of a baby’s umbilical cord blood. [Cord Blood America, Inc. Press Release]

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW 2nd International Conference on Stem Cells and Cancer
October 15-18, 2011
Pune, India

Visit
our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES
Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Industrial Postdoctoral Research Fellow (Regenerative Medicine Cell Therapy) (Tissue Regeneration Therapeutics Inc.)

Cord Blood Procurement Specialist (Karmanos Cancer Institute)

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