Volume 3.38 | Sep 29

Cord Blood News 3.38, September 29, 2011

     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Donor-Specific Anti-HLA Antibodies Predict Outcome in Double Umbilical Cord Blood Transplantation  
Using a uniform detection method for donor specific anti-HLA antibodies (DSA), researchers sought to determine the effect of preformed DSA on outcomes in double umbilical cord blood transplantation. [Blood] Abstract  

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Upfront Allogeneic Blood Stem Cell Transplantation for Patients with High Risk Myelodysplastic Syndrome or Secondary Acute Myeloid Leukemia Using a FLAMSA-Based High-Dose Sequential Conditioning Regimen   
The purpose of the prospective single center study was to examine the safety and efficacy of an allogeneic hematopoietic stem cell transplantation following a sequential conditioning regimen as first line therapy for previously untreated patients with high risk myelodysplastic syndrome (MDS) or AML secondary to MDS. [Blood] Abstract   

Haplo-Identical/Mismatched Hematopoietic Stem Cell Transplantation Without In Vitro T-Cell Depletion for T-Cell Acute Lymphocytic Leukemia   
The study confirmed that haplo-identical/mismatched hematopoietic stem cell transplantation could be an alternative treatment choice for T-cell acute lymphoblastic leukemia. [Blood] Abstract   

The Effect of Folinic Acid on Methylenetetrahydrofolate Reductase Polymorphisms in Methotrexate Treated Allogeneic Haematopoietic Stem Cell Transplants   
The study examined the contribution single nucleotide polymorphisms of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have on clinical outcomes in hematopoietic stem cell transplant patients treated with the anti-proliferative drug methotrexate. [Blood] Abstract   

DEK Regulates Hematopoietic Stem Engraftment and Progenitor Cell Proliferation   
Researchers hypothesized that DEK may modulate functions of hematopoietic stem and progenitor cells. [Stem Cells Dev] Abstract   

Compartmental Hollow Fiber Capillary Membrane Based Bioreactor Technology for In Vitro Studies on Red Blood Cell Lineage Direction of Hematopoietic Stem Cells   
The down-scaled culture technology allows for expansion of CD34+ cells and stimulating these progenitors towards red blood cell lineage, expressing approximately 40% CD235+ and enucleation. [Tissue Eng Part C Methods] Abstract   

Role of HLA-G and NCR in Protection of Umbilical Cord Blood Haematopoietic Stem Cells from NK Cell Mediated Cytotoxicity   
The studies aimed at investigating potential mechanisms of allogeneic umbilical cord blood haematopoietic stem cells escape from the cytolysis of natural killer (NK) cells. [J Cell Mol Med] Abstract   

Factors Predicting Single-Unit Predominance After Double Umbilical Cord Blood Transplantation   
The study examined the risk factor associated with unit predominance in 262 patients with hematologic malignancies who underwent double umbilical cord blood transplantation with subsequent hematopoietic recovery and complete chimerism between 2001 and 2009. [Bone Marrow Transplant] Abstract   

Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood   
The aim of the study was to characterize the CD25-expressing subset of B cells in human cord blood. [Clin Dev Immunol] Abstract   

A New Methodological Sequence to Expand and Transdifferentiate Human Umbilical Cord Blood Derived CD133+ Cells into a Cardiomyocyte-Like Phenotype   
In this study researchers investigated optimising a protocol for the expansion and subsequent differentiation of human umbilical cord blood derived CD133+ stem cells into a cardiomyocyte-like lineage. [Stem Cell Rev Rep] Abstract   

Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells After Intrathecal Administration by Lumbar Puncture in a Rat Model of Cerebral Ischemia   
To determine the therapeutic potential of intrathecal administration of mesenchymal stem cells (MSCs) by lumbar puncture, investigators administrated human umbilical cord blood-derived MSCs (hUCB-MSCs) intrathecally into the lumbar spinal cord or intravenously into the tail vein in a rat model of stroke, and then investigated whether hUCB-MSCs could enter the brain, survive, and improve poststroke neurological functional recovery. [Stem Cell Res Ther] Abstract   

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INDUSTRY NEWS

$12 Million Collaborative Grant Seeks to Improve Cord Blood Transplantation for Cancer Patients
A $12 million, five-year grant from the National Cancer Institute will help researchers from The University of Texas MD Anderson Cancer Center and the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and The Methodist Hospital improve outcomes of cord blood transplantation in children and adults with cancer. [Baylor College of Medicine] Press Release


Blood & Marrow Program Reports Best Survival Outcomes in the Nation
The National Marrow Donor Program has released outcome data that indicate Northside Hospital’s Blood & Marrow Transplant Program has, by far, the best survival rates for matched unrelated donor transplants of any program in the country. [Northside Hospital] Press Release

Cord Blood America Argentina Revenues Up 40 Percent

Cord Blood America, Inc. updated shareholders on the progress of Biocordcell Argentina S.A. (BioCells, Inc.), which is 50.1 percent owned by Cord Blood America. [Cord Blood America, Inc.] Press Release

Golden Meditech Increase Stake in NYSE-Listed Affiliate – China Cord Blood Corporation to 40.9%

Golden Meditech Holdings Limited announced that the Group has continued to increase its ownership in its NYSE-listed affiliate, China Cord Blood Corporation from the open market. [Golden Meditech Holdings Limited] Press Release

China Cord Blood Corporation Files Its Annual Report on Form 20-F
China Cord Blood Corporation announced that the Company has filed with the U.S. Securities and Exchange Commission its Annual Report on Form 20-F, which included audited financial statements for the fiscal year ended March 31, 2011. [China Cord Blood Corporation] Press Release

POLICY NEWS

International Society for Cellular Therapy (ISCT) Leads Roundtable with Major US Payors, Healthcare Providers and Industry to Initiate a Collaboration to Address Cell Therapy Product Reimbursement
In keeping with its mission to drive the commercialization of cell therapy products and advance global patient access, ISCT hosted its second event this year in its Commercial Development Series, this time focusing on the timely issue of reimbursement for cell therapy and regenerative medicine products in the US market. [International Society for Cellular Therapy] Press Release

National Institutes of Health (United States)
 
Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)
 
Medicines and Healthcare Products Regulatory Agency (United Kingdom)
 
Therapeutic Goods Administration (Australia) 

EVENTS

NEW Bench to Bedside: Blood and Marrow Transplantation  
December 16, 2011
London, United Kingdom


Visit
our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

Senior Laboratory Technician – Life Sciences (Matchtech)

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