Volume 3.39 | Oct 6

Cord Blood News 3.39, October 6, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Reduced-Intensity Conditioning with Combined Haploidentical and Cord Blood Transplantation Results in Rapid Engraftment, Low GVHD, and Durable Remissions
Investigators conducted a 45 patient prospective study of reduced intensity conditioning and transplantation of unrelated umbilical cord blood and CD34+ stem cells from a haploidentical family member. [Blood] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Engineering of Living Autologous Human Umbilical Cord Cell-Based Septal Occluder Membranes Using Composite PGA-P4HB Matrices
Here, researchers present the in vitro fabrication, crimping and experimental delivery of living human umbilical cord-cell derived tissue engineered occluder membranes based on composite matrices as a potential future autologous therapy of intracardiac wall defects. [Biomaterials] Abstract

The In Vitro and In Vivo Effects of Human Umbilical Cord Mesenchymal Stem Cells on the Growth of Breast Cancer Cells
The purpose of the study was to detect the effect and possible mechanism of human umbilical cord mesenchymal stem cells on the in vitro and in vivo growth of stem cells isolated from primary human breast cancer cells and cell lines MDA-MB-231 and MCF-7. [Breast Cancer Res Treat] Abstract

A Toxicity Study of Multiple-Administration Human Umbilical Cord Mesenchymal Stem Cells in Cynomolgus Monkeys
The study was designed to evaluate the overall toxicology of human umbilical cord mesenchymal stem cells in cynomolgus monkeys with repeated administration. [Stem Cells Dev] Abstract

A Novel Method for the Fabrication of Fibrin-Based Electrospun Nanofibrous Scaffold for Tissue-Engineering Applications
Cell attachment and proliferation studies revealed that the scaffold supports the attachment, spreading, and proliferation of human umbilical cord blood-derived mesenchymal stem cells. [Tissue Eng Part C Methods] Abstract

Human Umbilical Cord Wharton’s Jelly Stem Cells and its Conditioned Medium Support Hematopoietic Stem Cell Expansion Ex Vivo
Researchers explored the use of human umbilical cord Wharton’s jelly mesenchymal stromal cells (hWJSCs) and its conditioned medium for ex vivo expansion of hematopoietic stem cells in allogeneic and autologous settings because hWJSCs can be harvested in abundance painlessly, are proliferative, hypoimmunogenic and secrete a variety of unique proteins. [J Cell Biochem] Abstract

Umbilical Cord Blood Concentration of Soluble Scavenger Receptor for Hemoglobin, but not Pentraxin 3, Is of Value for the Early Postpartum Identification of the Presence of Histological Chorioamnionitis
The objective was to determine whether umbilical cord blood concentrations of soluble scavenger receptor for hemoglobin and pentraxin 3 are of value in the early postpartum diagnosis of histological chorioamnionitis in preterm prelabor rupture of membranes. [J Matern Fetal Neonatal Med] Abstract

Further Phenotypic Characterization of the Primitive Lineage− CD34+CD38−CD90+CD45RA− Hematopoietic Stem Cell/Progenitor Cell Sub-Population Isolated from Cord Blood, Mobilized Peripheral Blood and Patients with Chronic Myelogenous Leukemia
In order to investigate further purification of hematopoietic stem cells (HSCs) and for potential targetable differences between the very primitive normal and chronic myelogenous leukemia (CML) stem/progenitor cells (PCs), researchers have phenotypically compared the normal and CML Lin−CD34+CD38−CD90+CD45RA− HSC/PC populations. [Blood Cancer J] Abstract

A Comparison of Cryopreservation Methods: Slow-Cooling Vs. Rapid-Cooling Based on Cell Viability, Oxidative Stress, Apoptosis, and CD34+ Enumeration of Human Umbilical Cord Blood Mononucleated Cells
The study was conducted to compare the effectiveness of slow- and rapid-cooling to preserve umbilical cord blood of mononucleated cells suspected of containing hematopoietic stem cells. [BMC Res Notes] Abstract

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INDUSTRY NEWS

ISBT Bar Code Labeling System for Cellular Therapy
Digi-Trax® Corporation and STEMSOFT™ Software Inc. are pleased to announce that they will jointly work together to develop an integrated solution that connects the industry’s leading cell therapy laboratory software system, StemLab™, with Digi-Trax’s flagship Hema-Trax®-CT labeling solution. [STEMSOFT™ Software Inc.] Press Release

AuxoCell Laboratories Licenses Umbilical Cord Tissue Stem Cell Service to Portuguese Company Crioestaminal
AuxoCell Laboratories, Inc. announced an agreement with Crioestaminal allowing them to offer families the opportunity to bank newborn stem cells from an additional source – cord tissue. [MarketWatch] Press Release

The Centre for Commercialization of Regenerative Medicine (CCRM): CCRM Announces Its Inaugural Board of Directors
The Centre for Commercialization of Regenerative Medicine (CCRM) is proud to announce its inaugural Board of Directors. [Reuters] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW National Conference on Biopharmaceuticals & Healthcare
November 4-5, 2011
Bangalore, India

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

Senior Laboratory Technician – Life Sciences (Matchtech)

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