Volume 3.41 | Oct 20

Cord Blood News 3.41, October 20, 2011

     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Human Umbilical Cord Blood Mesenchymal Stem Cells Protect Mice Brain After Trauma  
The objectives of this study were to investigate whether human umbilical cord blood mesenchymal stem cells decrease traumatic brain injury sequelae and restore brain function, are able to survive and home to the lesioned region, and induce relevant changes in the environment in which they are infused. [Crit Care Med] Abstract  

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Proteome Analysis During Chondrocyte Differentiation in a New Chondrogenesis Model Using Human Umbilical Cord Stroma Mesenchymal Stem Cells 
The purpose of the study was to determine which proteins were differentially expressed during chondrogenesis. [Mol Cell Proteomics] Abstract 


Enrichment of Functionally Distinct Mouse Hematopoietic Progenitor Cell Populations Using CD62L    
The details of the bifurcation of the lymphoid and myeloid lineages following commitment by multipotent progenitor cells remain a topic of controversy. Investigators report that the surface glycoprotein CD62L can be characterized as a novel marker of this and other stages of early hematopoietic differentiation. [J Immunol] Abstract    

Mesenchymal Stem Cells Inhibit Thymic Reconstitution After Allogeneic Cord Blood Transplantation    
Researchers analyzed T-cell receptor excision circles, immunoglobulin G, and immunoglobulin M levels after cord blood transplantation in 50 patients transplanted at a center. [Stem Cells Dev] Abstract    

Prospective Study of One- vs Two-Unit Umbilical Cord Blood Transplantation Following Reduced Intensity Conditioning in Adults with Hematological Malignancies    
As the threshold nucleated cell dose for one-unit umbilical cord blood (UCB) in adults has not to date been firmly established, scientists prospectively compared one- vs two-unit UCB transplantation after reduced intensity conditioning in adult patients with hematological malignancies. [Bone Marrow Transplant] Abstract  


Reduced Intensity Conditioning Stem Cell Transplantation: Comparison of Double Umbilical Cord Blood with Unrelated Donors    
Researchers performed a retrospective analysis comparing reduced intensity conditioning hematopoietic stem cell transplantation using unrelated donors to double umbilical cord blood. [Biol Blood Marrow Transplant] Abstract    

Comparison of Unrelated Cord Blood Transplantation and HLA-Mismatched Unrelated Bone Marrow Transplantation for Adults with Leukemia   
Investigators assessed human leukocyte antigen (HLA)-mismatched locus-specific comparison of the outcomes of 351 single unit unrelated cord blood and 1,028 unrelated bone marrow adult recipients 16 years old or older at the time of transplant who received first stem cell transplantation with myeloablative conditioning for acute leukemia or myelodysplastic syndromes. [Biol Blood Marrow Transplant] Abstract  


Osteochondral Interface Regeneration of the Rabbit Knee with Macroscopic Gradients of Bioactive Signals 
Results indicated that there may be regenerative benefits to prelocalizing umbilical cord mesenchymal stromal cells within scaffold interiors. [J Biomed Mater Res A] Abstract 

Fusion of Human Umbilical Cord Mesenchymal Stem Cells with Esophageal Carcinoma Cells Inhibits the Tumorigenicity of Esophageal Carcinoma Cells 
Researchers investigated the effect of cell fusion of mesenchymal stem cells with esophageal carcinoma cells on tumorigenesis. [Int J Oncol] Abstract 

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INDUSTRY NEWS

Maryland Stem Cell Research Commission Issues Requests for Applications
Per the Maryland Stem Cell Commission (Commission) meeting on Sept.15, 2010, the Commission has issued three official Requests for Applications for funding through the Maryland Stem Cell Research Fund under the Maryland Stem Cell Research Act. [Maryland Stem Cell Research Fund] Press Release


GMP Certification Awarded To Cryo-Save Lab, India

Cryo-Save India has become the first to receive World Health Organisation – Good Manufacturing Procedures (WHO-GMP) certification. [Cryo-Save AG] Press Release


China Cord Blood Corporation to Hold Annual General Meeting in Hong Kong on December 19, 2011

China Cord Blood Corporation announced that the Company will hold its annual general meeting of shareholders at its Hong Kong office at 9:00 p.m. Hong Kong Time on December 19, 2011 (8:00 a.m. U.S. Eastern Time on December 19, 2011). [China Cord Blood Corporation] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Select Biosciences STEMCELLS 2012
February 2-3, 2012
San Diego, United States

Visit our events page  to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Senior Laboratory Technician – Life Sciences (Matchtech)

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