Volume 3.42 | Oct 27

Cord Blood News 3.42, October 27, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Soluble Intracellular Adhesion Molecule-1 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Reduces Amyloid-ß Plaques
Co-culture of human umbilical cord blood mesenchymal stem cells with BV2 microglia under amyloid-ß42 (Aß42) exposure induced a reduction of Aß42 in the medium as well as an overexpression of the Aß-degrading enzyme neprilysin in microglia. [Cell Death Differ] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

SOX2 Has a Crucial Role in the Lineage Determination and Proliferation of Mesenchymal Stem Cells Through Dickkopf-1 and c-MYC
In this study, researchers examined the molecular mechanisms of SOX2 in human mesenchymal stem cells by performing inhibition studies. [Cell Death Differ] Abstract

Generation and Differentiation of Microtissues from Multipotent Precursor Cells for Use in Tissue Engineering
Here investigators describe a detailed workflow for the production of microspheres using unrestricted somatic stem cells from human umbilical cord blood and adapted protocols for the use of these microspheres in histological analysis. [Nat Protoc] Abstract

Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide
Scientists conducted an open-label, phase I study using autologous umbilical cord blood infusion to ameliorate type 1 diabetes. Having previously reported on the first 15 patients reaching 1 year of follow-up, herein researchers report on the complete cohort after 2 years of follow-up. [Diabetes Care] Abstract

The Transcriptional Coactivator Cbp Regulates Self-Renewal and Differentiation in Adult Hematopoietic Stem Cells
Here, investigators demonstrate a gradual loss of phenotypic hematopoietic stem cells and differentiation defects following conditional ablation of Cbp during adult homeostasis. [Mol Cell Biol] Abstract

Activation of Wnt Signaling Arrests Effector Differentiation in Human Peripheral and Cord Blood-Derived T Lymphocytes
Investigators show that activation of Wnt/β-catenin signaling arrests human peripheral blood and cord blood T lymphocytes in the naive stage and blocks their transition into functional T effector cells. [J Immunol] Abstract

Human Umbilical Cord Blood-Derived Stromal Cells Are Superior to Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Inducing Myeloid Lineage Differentiation In Vitro
Researchers found that human umbilical cord blood-derived stromal cells are superior to human umbilical cord blood-derived mesenchymal stem cells in supporting hematopoiesis stem/progenitor cells differentiation into myeloid lineage cells at an early stage in vitro. [Stem Cell Dev] Abstract

Gas-Foaming Calcium Phosphate Cement Scaffold Encapsulating Human Umbilical Cord Stem Cells
The objectives of the study were to develop macroporous calcium phosphate cement (CPC)-chitosan-fiber construct containing alginate-fibrin microbeads encapsulating human umbilical cord mesenchymal stem cells (hUCMSCs), and investigate hUCMSC release from the degrading microbeads and proliferation inside the porous CPC construct for the first time. [Tissue Eng Part A] Abstract

Allogeneic Hematopoietic SCT for Primary Cutaneous T Cell Lymphomas
Researchers present outcomes of 12 extensively-pretreated patients with cutaneous T-cell lymphomas who underwent allogeneic hematopoietic stem cell transplantation (HSCT) using, most commonly, a reduced intensity conditioning regimen. [Bone Marrow Transplant] Abstract

Novel Three-Dimensional Long-Term Bone Marrow Culture System Using Polymer Particles with Grafted Epoxy-Polymer-Chains Supports the Proliferation and Differentiation of Hematopoietic Stem Cells
Researchers examined the hematopoietic supportive ability of stromal cells in a 3D culture system using polymer particles with grafted epoxy polymer chains. Umbilical cord blood-derived CD34+ cells were co-cultivated with MS-5 stromal cells. [Exp Biol Med]
Abstract

Umbilical Cord Blood Cells CD133+/CD133: Cultivation in Neural Proliferation Media
In the present study researchers investigated the possibility of whether stem cells in mononuclear umbilical cord blood grown under defined conditions can produce progeny with neural phenotype. [Arch Med Res] Abstract

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INDUSTRY NEWS

Cord Blood America Details Worldwide Research Using Umbilical Cord Blood Stem Cells
Cord Blood America provides insight on worldwide research using umbilical cord blood stem cells to treat numerous diseases. [Cord Blood America, Inc.] Press Release

CaridianBCT and Terumo Transfusion Unveil New Milestones in Progress Toward Becoming Terumo BCT at AABB Annual Meeting & CTTXPO 2011
CaridianBCT and Terumo Transfusion unveiled that they are uniting to become Terumo BCT, the world leader in blood component technology, products and services in the blood banking, transfusion medicine and cell therapy industries. [BusinessWire] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 7th Annual Stem Cell Summit
February 21, 2012
New York, United States

Visit our events page  to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Senior Laboratory Technician – Life Sciences (Matchtech)

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