Volume 3.44 | Nov 10

Cord Blood News 3.44, November 10, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Notch-Induced hIL-6 Production Facilitates the Maintenance of Self-Renewal of hCD34+ Cord Blood Cells through the Activation of Jak-PI3K-STAT3 Pathway
Results strongly demonstrate that Notch signaling in the “cell-to-cell contact” between hCD34+ cord blood and delta-like–expressing AFT024 feeder cells facilitates maintenance of self-renewal of hCD34+ cord blood cells through direct regulation of human IL-6 (hIL-6) production. [Am J Pathol] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

N-Cadherin Determines Individual Variations in the Therapeutic Efficacy of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rat Model of Myocardial Infarction
In this study, researchers established and characterized human umbilical cord blood-derived mesenchymal stem cells from four different donors. [Mol Ther] Abstract

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Undergo Cellular Senescence in Response to Oxidative Stress
Researchers found that that sublethal doses of reactive oxygen species and ionizing radiation cause DNA damage and reduce DNA synthesis and cell proliferation in human umbilical cord blood-derived mesenchymal stem cells, resulting in cellular senescence. [Stem Cells Dev] Abstract

Cationic Liposome-Mediated CXCR4 Gene Delivery into Hematopoietic Stem/Progenitor Cells: Implications for Clinical Transplantation and Gene Therapy
In this work, researchers investigated the non-viral CXCR4 gene delivery into hematopoietic stem/progenitor cells using the cationic liposome agent IBAfect. [Stem Cells Dev] Abstract

Intravenous Umbilical Cord Mesenchymal Stem Cell Infusion for the Treatment of Combined Malnutrition Nonunion of the Humerus and Radial Nerve Injury
Researchers applied umbilical cord mesenchymal stem cell therapy to one patient with both nonunion and nerve injury, and observed the therapeutic effects. [Regen Med] Abstract

Risk Factors for Progression from CMV Viremia to CMV Disease after Allogeneic Hematopoietic Stem Cell Transplantation
This study investigated the risk factors for progression from cytomegalovirus (CMV) viremia to CMV disease during or after pre-emptive therapy. [Biol Blood Marrow Transplant] Abstract

In Vivo Magnetic Resonance Imaging Tracking of SPIO Labeled Human Umbilical Cord Mesenchymal Stem Cells
This study evaluated the feasibility of in vivo tracking for human umbilical cord mesenchymal stem cells labeled by superparamagnetic iron oxide (SPIO) with noninvasive magnetic resonance imaging. [J Cell Biochem] Abstract

Comparison of Stem Cell Sources in the Severity of Dry Eye after Allogeneic Hematopoietic Stem Cell Transplantation
The aim of the study was to compare the incidence and severity of dry eye after allogeneic hematopoietic stem cell transplantation according to the stem cell source. [Br J Ophthalmol] Abstract

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INDUSTRY NEWS

New Cord Blood Donation Facility Opens at UCH 
Mums-to-be in central London will soon be able to donate lifesaving cord blood thanks to a new specialist collection service starting at University College Hospital (UCH) in London. [University College London Hospitals] Press Release

College Honored with National Marrow Donor Program’s Collegiate Award
The College of William & Mary received the National Marrow Donor Program’s Collegiate Award at the organization’s 24th annual council meeting in Minneapolis. [The College of William & Mary] Press Release

UCSF Training Program Attracts Best Minds in Developmental, Stem Cell Biology
Fittingly enough for a University where embryonic stem cells were first discovered in mice and named, the University of California, San Francisco (UCSF) has launched a pioneering program in Developmental and Stem Cell Biology. [University of California, San Francisco] Press Release

POLICY NEWS

National Heart, Lung, and Blood Institute; Notice of Closed Meetings (FR Doc No: 2011-28554) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 16th International HLA and Immunogenetics Workshop
May 28-June 3, 2012
Liverpool, United Kingdom

Visit
our events page  to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Laboratory Technician – Cord Blood Processing (Perkin Elmer)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

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