Volume 3.46 | Nov 24

Cord Blood News 3.46, November 24, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Efficient Reprogramming of Human Cord Blood CD34+ Cells into Induced Pluripotent Stem Cells with OCT4 and SOX2 Alone
Here, researchers show that the lentiviral expression of OCT4 together with SOX2 driven by a strong spleen focus-forming virus promoter in a single vector can convert 2% of cord blood CD34+ cells into induced pluripotent stem cells without additional reprogramming factors. [Mol Ther] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia
To identify FDA-approved agents targeting leukemic cells, researchers performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. [Cancer Cell] Abstract

Phenotypic and Functional Heterogeneity of Human NK Cells Developing after Umbilical Cord Blood Transplantation: A Role for Human Cytomegalovirus?
In this study, researchers analyzed the development of natural killer (NK) cells after intrabone umbilical cord blood transplantation in 18 adult patients with hematological malignancies. [Blood] Abstract

A Novel Lentivector Targets Gene Transfer into hHSC in Marrow from Patients with BM-Failure-Syndrome and In Vivo in Humanized Mice
The novel RDTR/stem cell factor-displaying lentiviral vectors selectively targeted transduction to 30-40% of the hCD34+-cells in cord blood mononuclear cells and in unfractionated BM of healthy and Fanconi anemia donors resulting in the correction of Fanconi patients’ CD34+-cells. [Blood]
Abstract

Distinct Differentiation Potential of “MSC” Derived from Cord Blood and Umbilical Cord: Are Cord-Derived Cells True MSC?
In order to determine whether cells isolated from human umbilical cord fulfill the criteria defined for mesenchymal stromal cells (MSC), the immunophenotype and differentiation potential including gene expression analysis of the most relevant lineage-specific markers were analyzed in the presented report in combination with the HOX-gene expression. [Stem Cells Dev] Abstract

Differential Signaling through ALK-1 and ALK-5 Regulates Leptin Expression in Mesenchymal Stem Cells
Here, researchers investigated leptin expression in mesenchymal stem cells from bone marrow and cord matrix. [Stem Cells Dev] Abstract

Toll-Like Receptors 2 and 4 Mediate the Capacity of Human Bone Marrow-Derived Mesenchymal Stromal Cells to Support the Proliferation and Differentiation of CD34+ Cells in a Non-Synergistic Way
Researchers explored the role of toll-like receptor 2 (TLR2) and TLR4 in mediating the capacity of bone marrow derived-mesenchymal stromal cells to support the proliferation and differentiation of CD34+ hematopoietic stem/progenitor cells obtained from cord blood. [Exp Cell Res] Abstract

Amelioration of Acute Graft-Versus-Host Disease by Adoptive Transfer of Ex Vivo Expanded Human Cord Blood CD4+CD25+ Forkhead Box Protein 3+ Regulatory T Cells Is Associated with the Polarization of Treg/Th17 Balance in a Mouse Model
Ex vivo expanded human cord blood (CB)-regulatory T cells (Tregs) significantly prevented allogeneic acute graft-versus-host disease (GVHD) in vivo by modulating various cytokine secretion and polarizing the Treg/Th17 balance toward Treg, which suggests the potential use of expanded CB-Tregs as a therapeutic approach for GVHD. [Transfusion] Abstract

The Impact of Bone Marrow Hematogones on Umbilical Cord Blood Transplant Outcomes in Acute Myeloid Leukemia Patients
Researchers hypothesized that early recovery of hematogones may be associated with improved transplant outcomes. [Biol Blood Marrow Transplant] Abstract

Comparison of Chemokine and Receptor Gene Expression between Wharton’s Jelly and Bone Marrow-Derived Mesenchymal Stromal Cells
Detailed chemokine and receptor gene expression profiles of Wharton’s jelly mesenchymal stromal cells (MSC) were established, and subsequently compared with those of bone marrow-derived MSC using a polymerase chain reaction array. [Cytotherapy] Abstract

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INDUSTRY NEWS

Cryo-Save Is Proud to Announce the Achievement of 200,000 Samples Stored from Umbilical Cord Blood and Umbilical Cord Tissue
This great achievement shows the successful results of Cryo-Save’s efforts in increasing the awareness of stem cell storage among the general public and the medical community. [Cryo-Save AG] Press Release

China Cord Blood Corporation to Report Second Quarter and First Half of Fiscal 2012 Financial Results
China Cord Blood Corporation announced its plan to release financial results for the second quarter and first half of fiscal year 2012 on Monday, November 28, 2011, after market close in the US. [China Cord Blood Corporation] Press Release

RNL Opens the World’s Largest Stem Cell Medical Center in Beijing, China
RNL BIO has just founded the world’s largest stem cell medical center in Beijing, China. [PR Newswire]
Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW International Society for Stem Cell Research 10th Annual Meeting
June 13-16, 2012
Yokohama, Japan

Visit our events page  to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Laboratory Technician – Cord Blood Processing (Perkin Elmer)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

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