Volume 3.48 | Dec 8

Cord Blood News 3.48, December 8, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
3D Co-Culture of Hematopoietic Stem and Progenitor Cells and Mesenchymal Stem Cells in Collagen Scaffolds as a Model of the Hematopoietic Niche
Here, investigators propose a collagen-based three-dimensional (3D) environment for hematopoietic stem and progenitor cells with mesenchymal stem cells derived either from bone marrow (BM) or umbilical cord, to recapitulate the main components of the BM niche. [Biomaterials] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells
Here scientists show that the requirements for core binding factor β in erythroid/myeloid progenitor and hematopoietic stem cell formation in the conceptus are temporally and spatially distinct. [Cell Stem Cell] Abstract

Expansion of Functionally Defined Mouse Hematopoietic Stem/Progenitor Cells by a Short Isoform of RUNX1/AML1
Findings establish the short isoform of RUNX1/AML1 as an isoform-specific molecule that can influence several transcriptional regulators associated with hematopoietic stem cells, leading to enhanced self-renewal activity and hematopoietic stem/progenitor cell expansion ex vivo and in vivo. [Blood] Abstract

Importance of Day 21 BM Chimerism in Sustained Neutrophil Engraftment following Double-Unit Cord Blood Transplantation
Researchers analyzed the association between BM assessment performed approximately 21 days after transplantation, and the speed and success of sustained donor-derived neutrophil engraftment in 56 myeloablative double-unit cord blood transplantation recipients. [Bone Marrow Transplant] Abstract

Differential Impact of Inhibitory and Activating Killer Ig-Like Receptors (KIR) on High-Risk Patients with Myeloid and Lymphoid Malignancies Undergoing Reduced Intensity Transplantation from Haploidentical Related Donors
The impact of activating KIR and inhibitory KIR on OS, relapse-related mortality and acute GVHD was prospectively studied in 84 adults with high-risk hematologic malignancies receiving reduced intensity conditioning T-cell depleted hematopoietic SCT from haploidentical related donors. [Bone Marrow Transplant] Abstract

Optimizing a Photoallodepletion Protocol for Adoptive Immunotherapy after Haploidentical SCT
Investigators determined the efficacy of photodynamic purging of alloreactive T cells, by investigating combinations of parameters in order to achieve maximum allodepletion, preservation of T-regulatory cells and of pathogen and leukemia-specific T-cell responses in donor-vs-recipient MLR. [Bone Marrow Transplant] Abstract

Initial Cord Blood Unit Volume Affects Mononuclear Cell and CD34+ Cell-Processing Efficiency in a Non-Linear Fashion
The present study focused on parameters influencing total nucleated cell, mononucleated cell and CD34+ cell recovery after routine volume reduction of 1553 umbilical cord blood units using hydroxyethyl starch-induced sedimentation with an automated device, under routine laboratory conditions. [Cytotherapy] Abstract

Functional Characterization of Transmembrane Intracellular pH Regulators and Mechanism of Alcohol-Induced Intracellular Acidosis in Human Umbilical Cord Blood Stem Cell–Like Cells
The aims of the present study were to investigate the physiological mechanisms of intracellular pH (pHi) recovery and to further explore the effects of alcohol on the pHi in human umbilical cord blood CD34+ stem cell–like cells. [J Cardiovasc Pharmacol] Abstract

Viability and Neural Differentiation of Mesenchymal Stem Cells Derived from the Umbilical Cord following Perinatal Asphyxia
The aim of this study was to examine the capacity for mesenchymal stem cells to differentiate into neural tissue that could subsequently be used for autologous transplantation. [J Perinatol] Abstract

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INDUSTRY NEWS

UCSF, GE Healthcare Team Up on Pioneering Cord Blood Project
The goal of the $841,000, three-year project is to make better use of a rich source of routinely discarded stem cells: umbilical cord blood gathered at the birth of a baby. [University of California, San Francisco (UCSF)] Press Release

Cord Blood America CEO Matthew Schissler Interviewed On 2011 Financial Performance, Stock Price, 2012 Strategies
Cord Blood America, Inc. said that co-founder and CEO Matthew Schissler was interviewed by analyst Francis Gaskins about the Company’s 2011 financial performance. [Cord Blood America, Inc.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 3rd International Congress on Responsible Stem Cell Research
April 25-28, 2012
Vatican City, Italy

Visit
our events page  to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Laboratory Technician – Cord Blood Processing (Perkin Elmer)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

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