Volume 4.06 | Feb 16

Cord Blood News 4.06, February 16, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Differentiation of Umbilical Cord Mesenchymal Stem Cells into Steroidogenic Cells in Comparison to Bone Marrow Mesenchymal Stem Cells
In this study, umbilical cord Wharton’s jelly-derived mesenchymal stem cells (MSCs) were induced to become steroidogenic cells and compared to bone marrow-derived MSCs. [Cell Prolif] Abstract

Watch The Video: Performing CFC Assays Using MethoCult™
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Infection-Responsive Expansion of the Hematopoietic Stem and Progenitor Cell Compartment in Zebrafish Is Dependent upon Inducible Nitric Oxide
Using a zebrafish model of demand-driven granulopoiesis to explore the hematopoietic stem and progenitor cell (HSPC) response to infection, investigators present data supporting a model where the zebrafish ortholog of the cytokine-inducible form of nitric oxide synthase (iNOS/NOS2) Nos2a acts downstream of the transcription factor C/ebpβ to control expansion of HSPCs following infection. [Cell Stem Cell]
Abstract | Press Release

The Combination of Valproic Acid and Lithium Delays Hematopoietic Stem/Progenitor Cell Differentiation
The ability to inhibit hematopoietic stem/progenitor cell commitment in culture may be of benefit to cell therapy protocols. Here, investigators tested two small molecules, valproic acid and lithium to inhibit differentiation. [Blood] Abstract

Differential Role of Actin-Binding Proteins in Controlling the Adipogenic Differentiation of Human CD105-Positive Wharton’s Jelly Cells
Wharton’s Jelly cells subjected to adipocyte induction were observed for changes in the cell morphology and alterations in actin filament formation. [Biochim Biophys Acta] Abstract

Characteristics of Thawed Autologous Umbilical Cord Blood
Using a standardized thaw-wash method, autologous umbilical cord blood samples were assessed for viable total nucleated cells (vTNCs), viable CD34+, and colony-forming unit-granulocyte-macrophage counts. Postthaw %vTNC recoveries were compared against processing characteristics and analyzed according to processing method, cryopreservation volume, concentration, container, and length of storage. [Transfusion] Abstract

Cryopreservation of Umbilical Cord Blood with a Novel Freezing Solution that Mimics Intracellular Ionic Composition
This study evaluated the preservation efficacy of a novel intracellular-like cryopreservation solution, the rate of addition of two cryopreservation solutions to cord blood units, and reduced final dimethyl sulfoxide concentration of 5%. [Transfusion] Abstract

Early CD3 Peripheral Blood Chimerism Predicts the Long-Term Engrafting Unit following Myeloablative Double Cord Blood Transplantation
Beginning at day seven post-transplant, researchers prospectively measured weekly lineage-specific peripheral blood donor chimerisms in patients undergoing myeloablative double cord blood transplantation to evaluate whether the degree of early donor contribution to specific lineage(s) would predict the long-term engrafting unit. [Biol Blood Marrow Transplant] Abstract

Myeloablative Transplantation Using Either Cord Blood or Bone Marrow Leads to Immune Recovery, High Long-Term Donor Chimerism and Excellent Survival in Chronic Granulomatous Disease
Twelve consecutive children with severe chronic granulomatous disease received myeloablative hematopoietic stem cell transplantation using sibling bone marrow, unrelated cord blood, and sibling cord blood. [Biol Blood Marrow Transplant] Abstract

Human Cord Blood-Derived Multipotent Stem Cells (CB-SCs) Treated with All-Trans-Retinoic Acid (ATRA) Give Rise to Dopamine Neurons
To explore their therapeutic potential in Parkinson’s disease, researchers examined whether CB-SCs could be induced to differentiate into dopamine neurons in the presence of ATRA. [Biochem Biophys Res Commun] Abstract

Tech Bulletin: Expansion Of Hematopoietic Stem And Progenitor Cells

INDUSTRY NEWS

The Gamida Cell-Teva Joint Venture Concludes Enrollment for the Phase III Study of StemEx®, a Cord Blood Stem Cell Product, for Leukemia and Lymphoma
Gamida Cell announced that the Gamida Cell-Teva Joint Venture, equally held by Gamida Cell and Teva Pharmaceutical Industries, has enrolled the last of 100 patients in the international, multi-center, pivotal registration, Phase III clinical trial of StemEx, a cell therapy product in development as an alternative therapeutic treatment for adolescents and adults, with blood cancers such as leukemia and lymphoma, who cannot find a family related, matched bone marrow donor. [Gamida Cell] Press Release

St. David’s Medical Center First in Austin to Become Certified Cord Blood Collection Center
On Feb. 14, 2012, St. David’s Medical Center became the first hospital in Austin to join the Texas Cord Blood Bank’s cord blood collection program. [South Texas Blood & Tissue Center] Press Release

Harvard Scientist to Lead USC Center in Stem Cell Research
Biologist Andrew P. McMahon will leave Harvard University to join the Keck School of Medicine of the University of Southern California (USC) as a Provost Professor and the inaugural holder of the W. M. Keck Professorship of Stem Cell Biology and Regenerative Medicine. [University of Southern California]
Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Experimental Biology (EB) 2012
April 21-25, 2012
San Diego, United States

NEW Select Biosciences: Stem Cells & Bioprocessing Europe
June 27-28, 2012
London, United Kingdom

Visit our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Research Technologist (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)

Postdoctoral Position – Stem Cell Research (Tsinghua University Graduate School at Shenzhen)


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