Volume 4.07 | Feb 23

Cord Blood News 4.07, February 23, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Cord Blood Stem Cells Inhibit Epidermal Growth Factor Receptor Translocation to Mitochondria in Glioblastoma
Researchers analyzed the effect of human umbilical cord blood stem cells on the inhibition of epidermal growth factor receptor (EGFR) expression and EGFR signaling in glioma cells and xenografts. [PLoS One] Abstract

Video: Enumerate Total Hematopoietic Progenitors In Cord Blood In Only 7 Days
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Single-Unit Umbilical Cord Blood Transplantation from Unrelated Donors in Patients with Hematological Malignancy Using Busulfan, Thiotepa, Fludarabine and ATG as Myeloablative Conditioning Regimen
This study shows high rates of engraftment with fast neutrophil recovery in patients undergoing single-unit cord blood transplantation using a BU-based conditioning regimen. [Bone Marrow Transplant] Abstract

Comparative Study of Regulatory T Cells Expanded Ex Vivo from Cord Blood and Adult Peripheral Blood
In this study, researchers expanded regulatory T cells (Tregs) ex vivo from CD4+CD25+ T cells from cord blood and CD4+CD25+CD127- T cells from adult peripheral blood and compared the suppressive functions of the newly generated Tregs. [Immunology] Abstract

Unrelated Donor Cord Blood Transplantation for Children with Severe Sickle Cell Disease: Results of One Cohort from the Phase II Study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN)
The sickle cell unrelated donor transplant trial of the BMT CTN is a phase II study of the toxicity and efficacy of unrelated donor hematopoietic cell transplantation in children with severe sickle cell disease using a reduced intensity conditioning regimen. Here investigators report the results for the cord blood cohort of this trial. [Biol Blood Marrow Transplant] Abstract

Human Umbilical Cord Provides a Significant Source of Unexpanded Mesenchymal Stromal Cells
This study demonstrates that, using umbilical cord, large numbers of mesenchymal stromal cells (MSC) can be safely obtained using a simple procedure without in vitro expansion, and these non-expanded MSC have the potential to suppress graft-versus-host disease. [Cytotherapy] Abstract

Human Umbilical Cord Mesenchymal Stem Cells Improve Liver Function and Ascites in Decompensated Liver Cirrhosis Patients
This study examined the safety and efficacy of umbilical cord-derived mesenchymal stem cells in patients with decompensated liver cirrhosis. [J Gastroenterol Hepatol] Abstract

Successful Unrelated Umbilical Cord Blood Transplantation in Lesch-Nyhan Syndrome
As hematopoietic stem cell transplantation has been shown to be effective in several neurodevelopmental inborn errors, researchers hypothesized that it could be favorable in Lesch-Nyhan syndrome as well. [Metab Brain Dis] Abstract

Distribution of CD4+CD25highFoxP3+ Regulatory T-Cells in Umbilical Cord Blood
This study aimed to establish reference intervals for lymphocyte subsets including CD4+CD25highFoxP3+ regulatory T-cells in umbilical cord blood. [J Matern Fetal Neonatal Med] Abstract

New Approach for Isolation of Mesenchymal Stem Cells (MSCs) from Human Umbilical Cord Blood
The aim of this study was to establish a new method for isolating large number of MSCs from the human umbilical cord blood in order to be recognized as a good source of MSCs. [Cell Biol Int] Abstract

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells (hUCB-MSC) Inhibit the Proliferation of K562 (Human Erythromyeloblastoid Leukemic Cell Line)
The objectives of this study were to evaluate the effect of hUCB-MSC on the proliferation of K562 and the cytokine secretion pattern of hUCB-MSC. [Cell Biol Int] Abstract

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INDUSTRY NEWS

Cellerant Therapeutics Appoints Lowell E. Sears to Board of Directors
Cellerant Therapeutics Inc. announced that Lowell E. Sears joined its Board of Directors. [Cellerant Therapeutics Inc.] Press Release

University of Florida President Appointed to Sanford-Burnham’s Board of Trustees
Sanford-Burnham Medical Research Institute (Sanford-Burnham) announced that University of Florida President Bernie Machen has joined its Board of Trustees. [Sanford-Burnham Medical Research Institute] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Engineering Conferences International (ECI) – Cell Culture Engineering XIII
April 22-27, 2012
Scottsdale, United States

Visit
our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Research Technologist (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)

Postdoctoral Position – Stem Cell Research (Tsinghua University Graduate School at Shenzhen)


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