Volume 4.08 | Mar 1

Cord Blood News 4.08, March 1, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Distinct but Phenotypically Heterogeneous Human Cell Populations Produce Rapid Recovery of Platelets and Neutrophils Post-Transplant
Researchers show that human cord blood and mobilized peripheral blood collections contain cells that produce platelets and neutrophils within three-weeks after being transplanted into sublethally irradiated NOD/SCID-IL-2Rγc-null mice. [Blood] Abstract

Tech Bulletin: Expansion Of Hematopoietic Stem And Progenitor Cells
PUBLICATIONS (Ranked by Impact Factor of the Journal)

An Acute Negative Bystander Effect of γ-Irradiated Recipients on Transplanted Hematopoietic Stem Cells in Mice
In this study, researchers found that irradiated mouse recipients significantly impaired the long-term repopulating ability of transplanted mouse hematopoietic stem cells shortly after exposure to irradiated hosts and before the cells began to divide. [Blood] Abstract

Endothelial Progenitor Cell Cotransplantation Enhances Islet Engraftment by Rapid Revascularization
Since endothelial progenitor cells (EPCs) are known to aid neovascularization, investigators aimed to enhance islet engraftment by cotransplanting EPCs with islets. Porcine islets, with or without human cord blood-derived EPCs, were transplanted into diabetic nude mice. [Diabetes] Abstract

Preclinical Safety and Efficacy of Human CD34+ Cells Transduced with Lentiviral Vector for the Treatment of Wiskott-Aldrich Syndrome
Researchers evaluated the preclinical safety and efficacy of human CD34+ cells transduced with lentiviral vectors encoding Wiskott-Aldrich syndrome protein. [Mol Ther] Abstract

Up-Regulation of miR-210 by Vascular Endothelial Growth Factor in Ex Vivo Expanded CD34+ Cells Enhances Cell-Mediated Angiogenesis
Researchers sought to evaluate the role of vascular endothelial growth factor (VEGF) in expansion and angiogenic function of CD34+ cells and identify specific microRNAs (miRs) associated with angiogenic properties of expanded cells. Umbilical cord blood CD34+ cells were effectively expanded in culture medium containing stem cell factor, Flt-3 ligand, thrombopoietin, and interleukin-6 with and without VEGF. [J Cell Mol Med] Abstract

CD200 Positive Human Mesenchymal Stem Cells Suppress TNF-Alpha Secretion from CD200 Receptor Positive Macrophage-Like Cells
The present study on 20 human mesenchymal stem cells lines shows that the CD200 expression pattern varied from high to medium and low in bone marrow-derived mesenchymal stem cell lines, whereas umbilical cord blood derived mesenchymal stem cells were constantly negative for CD200. [PLoS One] Abstract

Clostridium difficile Infection after Allogeneic Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors and Outcome
The purpose of this study was to evaluate the incidence, risk factors and outcome of C. difficile infection after hematopoietic stem cell transplantation. [Biol Blood Marrow Transplant] Abstract

Dexamethasone Has Variable Effects on Mesenchymal Stromal Cells
Mesenchymal stromal cells (MSC) were obtained from human umbilical cord. The surface phenotype and functional characterization of MSC cultured with different concentrations of dexamethasone were investigated, in comparison with a control group, including MSC proliferation, apoptosis, cytokine expression and immunosuppression. [Cytotherapy] Abstract

Senescence of Fetal Endothelial Progenitor Cell in Pregnancy with Idiopathic Fetal Growth Restriction
The aim of this study was to investigate the change of count and the status of cellular senescence in fetal endothelial progenitor cells obtained from the umbilical cord blood of women with fetal growth restriction. [J Matern Fetal Neonatal Med] Abstract

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INDUSTRY NEWS

CBR’s Newborn Possibilities Program Provides Cord Blood Banking at No Cost to Families with an Identified Medical Need
CBR® (Cord Blood Registry®) is working to expand awareness about its Newborn Possibilities Program® to expectant parents nationwide. This corporate initiative is designed to ensure that a newborn’s stem cells are processed and stored at no cost in cases of identified medical need and high-risk deliveries to enhance treatment options and increase access to clinical trials for conditions where limited therapies currently exist. [Cord Blood Registry®] Press Release

Virginia G. Piper Cancer Center Opens Cancer Transplant Institute
The Virginia G. Piper Cancer Center at Scottsdale Healthcare announced it has added a hematopoietic stem cell transplant cancer treatment program through its new Cancer Transplant Institute. [Scottsdale Healthcare] Press Release

ISSCR Honors Stem Cell Research Pioneer with Prestigious McEwen Award for Innovation
The 2012 McEwen Award for Innovation recipient is Rudolf Jaenisch, MD, in recognition of his pioneering discoveries in the areas of genetic and epigenetic control of development in mice that directly impact the future potential of embryonic stem cells and induced pluripotent stem cells for therapeutic utility. [International Society for Stem Cell Research (ISSCR)] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 2012 Till & McCulloch Meetings
April 30-May 2, 2012
Montreal, Canada

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Research Technologist (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

Postdoctoral Position – Stem Cell Research (Tsinghua University Graduate School at Shenzhen)


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