Volume 4.12 | Mar 29

Cord Blood News 4.12, March 29, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Spherical Bullet Formation via E-Cadherin Promotes Therapeutic Potency of Mesenchymal Stem Cells Derived from Human Umbilical Cord Blood for Myocardial Infarction
Scientists developed the spheroid three dimensional bullet as a delivery method for human umbilical cord blood-derived mesenchymal stem cells through the maintenance of cell-cell interactions without additional xenofactors, cytokines, or matrix. [Mol Ther] Abstract

Video: Enumerate Total Hematopoietic Progenitors In Cord Blood In Only 7 Days
PUBLICATIONS (Ranked by Impact Factor of the Journal)
The ATM–BID Pathway Regulates Quiescence and Survival of Hematopoietic Stem Cells
Researchers show that ATM-mediated BID phosphorylation plays an unexpected role in maintaining the quiescence of hematopoietic stem cells. [Nat Cell Biol] Abstract

The miR-17-92 Cluster Expands Multipotent Hematopoietic Progenitors While Imbalanced Expression of its Individual Oncogenic miRNAs Promotes Leukemia in Mice
The present study demonstrates that retroviral-mediated miR-17-92 overexpression promotes expansion of multipotent hematopoietic progenitors in mice. [Blood] Abstract

Intrapancreatic Delivery of Human Umbilical Cord Blood Aldehyde Dehydrogenase-Producing Cells Promotes Islet Regeneration
Researchers sought to investigate the stimulation of islet regeneration by transplanted human umbilical cord blood cells purified according to high aldehyde dehydrogenase activity, a conserved characteristic of multiple progenitor lineages. [Diabetologia] Abstract

T-Cell Replete Fludarabine/Cyclophosphamide Reduced Intensity Allogeneic Stem Cell Transplantation for Lymphoid Malignancies
Investigators report the outcome of 73 patients with lymphoid malignancies who received reduced-intensity allogeneic stem cell transplantation with a fludarabine/cyclophosphosphamide conditioning regimen and a median follow-up of 3 years. [Br J Haematol] Abstract

High Efficiency of Reprogramming CD34+ Cells Derived from Human Amniotic Fluid into Induced Pluripotent Stem Cells with Oct4
To generate induced pluripotent stem cells, CD34+ cells, isolated from human amniotic fluid cells by flow cytometry, were infected with retroviruses carrying only one reprogramming factor (Oct4) and cultured on human amniotic epithelial cell feeder layers. [Stem Cells Dev] Abstract

Non-Rigid Calcium Phosphate Cement Containing Hydrogel Microbeads and Absorbable Fibers Seeded with Umbilical Cord Stem Cells for Bone Engineering
The objectives of this study were to develop a non-rigid calcium phosphate cement (CPC) with microbeads and fiber reinforcement; and investigate human umbilical cord mesenchymal stem cell proliferation, osteodifferentiation and mineralization on non-rigid CPC for the first time. [J Tissue Eng Regen Med] Abstract

Safety and Feasibility of Countering Neurological Impairment by Intravenous Administration of Autologous Cord Blood in Cerebral Palsy
Scientists conducted a pilot study of the infusion of intravenous autologous cord blood in children with cerebral palsy to assess the safety and feasibility of the procedure as well as its potential efficacy in countering neurological impairment. [J Transl Med] Abstract

Allogeneic Hematopoietic Stem Cell Transplant with Reduced-Intensity Conditioning for Chronic Lymphocytic Leukemia in Sweden: Does Donor T-Cell Engraftment 3 Months After Transplant Predict Survival?
Thirty-eight adult patients with chronic lymphocytic leukemia underwent reduced-intensity conditioning allogeneic stem cell transplant in Sweden between 1999 and 2007. [Leuk Lymphoma] Abstract

Improve Quality Control and Regulatory Compliance. Watch the video to see how StemLab can help.
INDUSTRY NEWS
Cordlife Group to Raise $24 Million in Singapore IPO
Cordlife Group Ltd, a cord blood and tissue banking service provider, is launching an initial public offering (IPO) in Singapore to raise nearly S$30 million ($23.7 million). [Reuters] Press Release

Oncology Professionals and Leaders Honored for Contributions in the Progress Against Cancer
A former Surgeon General of the United States and leading researcher in leukemia in adults are among the notable awardees set to be honored by the American Society of Clinical Oncology at its 2012 Annual Meeting. [American Society of Clinical Oncology] Press Release

STEMSOFT: Here to Stay
STEMSOFT Software, the leading provider of blood and marrow transplant software solutions, is pleased to continue their dedication to serving the blood and marrow transplant community. [STEMSOFT Software Inc.] Press Release
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Stem Cells USA & Regenerative Medicine Congress
September 20-21, 2012
Boston, United States


Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Stem Cell Technician (Kelly Scientific Resources)

Medical Technologist II – Cellular Therapy (San Diego Blood Bank)


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