Volume 4.13 | Apr 5

Cord Blood News 4.13, April 5, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Definitive Set-Up of Clinical-Scale Procedure for Ex Vivo Expansion of Cord Blood Hematopoietic Cells for Transplantation
Scientists recently developed a clinical grade ex vivo cord blood expansion procedure enabling a massive amplification of hematopoietic progenitors without any loss of stem cell potential. [Cell Transplant] Abstract

Hematopoietic Course for Cord Blood - Learn More and Register
PUBLICATIONS (Ranked by Impact Factor of the Journal)
Proteomic Cornerstones of Hematopoietic Stem Cell Differentiation: Distinct Signatures of Multipotent Progenitors and Myeloid Committed Cells
Scientists applied an in-depth quantitative proteomic approach to analyze and compare the full proteomes of ex vivo isolated and FACS-sorted populations highly enriched for either multipotent hematopoietic stem/progenitor cells or myeloid committed precursors. [Mol Cell Proteomics] Abstract

Prenatally Engineered Autologous Amniotic Fluid Stem Cell-Based Heart Valves in the Fetal Circulation
The presented study investigates the fetal implantation of prenatally engineered living autologous cell-based heart valves. [Biomaterials] Abstract

Histone Deacetylase 3 (HDAC-3) Modulates the Expansion of Human Hematopoietic Stem Cells
Investigators have identified the valproic acid target HDAC3 as a negative regulator of umbilical cord blood hematopoietic stem cell expansion. [Stem Cells Dev] Abstract

Protein Segregation Between Dividing Hematopoietic Progenitor Cells in the Determination of the Symmetry/Asymmetry of Cell Division
Scientists investigated how the symmetry/asymmetry of cell division in mitotic CD34+ cells can be evaluated by determining the plane of cell division and the potential distribution of proteins between daughter cells. [Stem Cells Dev] Abstract

In Search for Cross-Reactivity to Immunophenotype Equine Mesenchymal Stromal Cells by Multicolor Flow Cytometry
Umbilical cord blood-derived undifferentiated equine mesenchymal stem cells of the fourth passage of six horses were characterized using multicolor flow cytometry based on the selected nine-marker panel of both cell surface antigens and intracytoplasmatic proteins. [Cytometry A] Abstract

Insulin-Like Growth Factor Binding Protein-2 and Neurotrophin 3 Synergize Together to Promote the Expansion of Hematopoietic Cells Ex Vivo
To determine whether neurotrophin-3 and insulin-like growth factor binding protein-2 are partly responsible for the growth promoting potential of mesenchymal stem cells, researchers investigated their impact on the growth and differentiation of umbilical cord blood-CD34+ cells. [Cytokine] Abstract

Survival of Cord Blood Hematopoietic Stem Cells in a Hyaluronan Hydrogel for Ex Vivo Biomimicry
The hyaluronic acid scaffold has been used for the first time to maintain long-term cultures of CD34+ hematopoietic cells obtained from human cord blood. [J Tissue Eng Regen Med] Abstract

Neuroprotective Effects of Human Umbilical Cord Mesenchymal Stromal Cells in an Immunocompetent Animal Model of Parkinson’s Disease
Scientists evaluated whether the transplantation of human mesenchymal stromal cells obtained from umbilical cord had a neuroprotective effect in a not-immunosuppressed rat Parkinson’s disease model. [J Neuroimmunol] Abstract

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INDUSTRY NEWS
ThermoGenesis Announces AABB Accreditation for Cord Blood Products Customer in China
ThermoGenesis Corp. said that its customer Beike Biotechnology Co., Ltd. has become the first company in China to receive accreditation from the AABB. [ThermoGenesis Corporation] Press Release

Canada and Japan Establish New Research Partnership
The Canadian Institutes of Health Research and the Japan Science and Technology Agency recently signed a partnership agreement to fund joint research projects on the epigenetics of stem cells. [Canadian Institutes of Health Research] Press Release

REMEDI Announces Collaborations with Chinese Universities
The Regenerative Medicine Institute (REMEDI) based at the National University of Galway has signed collaborative agreements with the Shanghai Institute for Pediatric Research and the Tangdu Neurosurgery & Neurology Hospital. The agreement will see REMEDI work closely with both Chinese partners in a number of research areas and will facilitate student and researcher exchange between Galway and China. [The Regenerative Medicine Institute] Press Release

Grant of Share Options
Cryo-Save Group N.V. announced that the Group granted options to subscribe for ordinary shares in the Company under the Cryo-Save Group 2009 Share Option Scheme on 2 April 2012. [Cryo-Save Group N.V.] Press Release
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW The 2012 Stem Cell Discussion Forum
October 3, 2012
London, United Kingdom

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Stem Cell Technician (Kelly Scientific Resources)

Medical Technologist II – Cellular Therapy (San Diego Blood Bank)


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