Volume 4.16 | Apr 26

Cord Blood News 4.16, April 26, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Long-Lasting Paracrine Effects of Human Cord Blood Cells (hUCBCs) on Damaged Neocortex in an Animal Model of Cerebral Palsy
Scientists performed a study on the use of hUCBCs in a rat model of neonatal hypoxiaischemia and investigated the underlying mechanism for therapeutic benefits of hUCBCs treatment. [Cell Transplant] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Restricted Myogenic Potential of Mesenchymal Stromal Cells Isolated from Umbilical Cord
Researchers documented that limited fraction of umbilical cord mesenchymal stromal cells express markers of pluripotent and myogenic cells. [Cell Transplant] Abstract

Bilayered Constructs Aimed at Osteochondral Strategies: The Influence of Medium Supplements in the Osteogenic and Chondrogenic Differentiation of Amniotic Fluid-Derived Stem Cells
Amniotic fluid-derived stem cell-seeded scaffolds were cultured for one or two weeks in an osteochondral-defined culture medium containing both osteogenic and chondrogenic differentiation factors. [Acta Biomater] Abstract

Human Umbilical Cord Matrix Stem Cells Efficiently Rescue Acute Liver Failure through Paracrine Effects Rather than Hepatic Differentiation
Researchers examined the therapeutic potential and the different mechanisms of human umbilical cord matrix stem cells by their transplantation into nonobese diabetic severe combined immunodeficient mice with CCl4-induced acute liver failure in comparison to adult human hepatocytes. [Tissue Eng Part A] Abstract

Human Amniotic Fluid-Derived Stem Cells Expressing Cytosine Deaminase and Thymidine Kinase Inhibits the Growth of Breast Cancer Cells in Cellular and Xenograft Mouse Models
Investigators used human amniotic fluid-derived stem cells as vehicles for targeted delivery of therapeutic suicide genes to breast cancer cells. [Cancer Gene Ther] Abstract

Cryopreservation of Umbilical Cord Mesenchymal Cells in Xenofree Conditions
The optimal cryopreservation methods, cryoprotector solutions and mesenchymal stem cell sensitivity to dimethyl sulfoxide exposure are unknown. This study investigated these issues. [Cytotherapy] Abstract

Transplantation of Human Umbilical Cord Blood Cells Mediated Beneficial Effects on Apoptosis, Angiogenesis and Neuronal Survival after Hypoxic-Ischemic Brain Injury in Rats
The mechanisms by which transplanted cells mediate functional recovery after brain injury are largely unknown. Researchers investigated the effects of human umbilical cord blood cell transplantation in this experimental paradigm at the cellular and molecular level. [Cell Tissue Res] Abstract

Dual Regeneration of Muscle and Nerve by Intravenous Administration of Human Amniotic Fluid-Derived Mesenchymal Stem Cells Regulated by Stromal Cell-Derived Factor-1α in a Sciatic Nerve Injury Model
The authors investigated the feasibility of intravenous administration of human amniotic fluid-derived mesenchymal stem cells according to stromal cell-derived factor-1α expression time profiles to facilitate neural regeneration in a sciatic nerve crush injury model. [J Neurosurg] Abstract

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INDUSTRY NEWS

First-of-Its-Kind Northern California Public Blood Collection Program Opens at Packard Children’s
A new public cord blood collection program at Lucile Packard Children’s Hospital at Stanford is now enabling new parents to donate their baby’s cord blood to an international stem cell transplant registry. [Lucile Packard Children’s Hospital] Press Release

Cryo-Save Hires Stem Cell Expert in the Flagship Lab in Niel, Belgium
Dr. Jurga will supervise new process validation at the Cryo-Save labs and study new processing techniques for umbilical cord blood, cord tissue and fat tissue, to ensure quality and use of the highest technology available on the market. [Cryo-Save AG] Press Release

Insception Cord Blood Program Expands to Vancouver
Insception announced the opening of their Vancouver office. As Canada’s largest and most established cord blood program, Insception is proud to support Vancouver and surrounding communities throughout British Columbia. [Marketwire, Incorporated] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Origins of Tissue Stem Cells
June 28-29, 2012
Edinburgh, United Kingdom

Visit
our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Development Scientist – Cell Therapy (GE Healthcare)

Group Leaders, Principle Scientists – Stem Cell Clinical Product R&D (Shanghai Hengrui Pharmaceuticals Co., Ltd)


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