Volume 4.18 | May 10

Cord Blood News 4.18, May 10, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
RNAi Screen Identifies MAPK14 as a Druggable Suppressor of Human Hematopoietic Stem Cell Expansion
Scientists identified MAPK14/p38a as a modulator of ex vivo stem cell proliferation and showed that pharmacological inhibition of p38 dramatically enhances the stem cell activity of cultured umbilical cord blood derived hematopoietic cells. [Blood] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Impact of Pre-Transplant Minimal Residual Disease after Cord Blood Transplantation for Childhood Acute Lymphoblastic Leukemia in Remission. An Eurocord, PDWP-EBMT Analysis
To address the prognostic value of minimal residual disease before unrelated cord blood transplantation in children with acute lymphoblastic leukemia (ALL), researchers analyzed 170 ALL children transplanted in complete remission after myeloablative conditioning regimen. [Leukemia] Abstract

Mild Hyperthermia Promotes and Accelerates the Development and Maturation of Erythroid Cells
Investigators hypothesized that Mild Hyperthermia (MH) could impact the differentiation of hematopoietic progenitors into erythrocytes and their subsequent maturation. Cell growth and erythroid differentiation increased dramatically in cord blood CD34+ cell cultures incubated under MH. [Stem Cells Dev] Abstract

Transplantation of Cord Blood Mesenchymal Stem Cells as Spheroids Enhances Vascularization
Researchers investigated whether the angiogenic efficacy of cord blood mononuclear cells can be enhanced by grafting as spheroids in a mouse hindlimb ischemia model. [Tissue Eng Part A] Abstract

Umbilical Cord Blood-Derived Stromal Cells Regulate Megakaryocytic Proliferation and Migration through SDF-1/PECAM-1 Pathway
The authors demonstrated that human umbilical cord blood-derived stromal cells secreted stromal cell derived factor-1 (SDF-1) to stimulate platelet endothelial cell adhesion molecule-1 (PECAM-1) expression in HEL cells, and consequently promoted the proliferation and migration of HEL cells. [Cell Biochem Biophys] Abstract

Human Cord Blood CD133+ Cells Exacerbate Ischemic Acute Kidney Injury in Mice
Data indicates that human cord blood-derived CD133+ cells unexpectedly exacerbate ischemic acute kidney injury in mice, possibly through soluble factors. [Nephrol Dial Transplant] Abstract

The Secretome of Stem Cells Isolated from the Adipose Tissue and Wharton’s Jelly Acts Differently on Central Nervous System-Derived Cell Populations
Researchers aimed to determine if stromal/stem cells isolated from the adipose tissue and umbilical cord preferentially act, or not, on specific cell populations within the central nervous system. [Stem Cell Res Ther] Abstract

Validation of Human Monoclonal HLA Class I Antibodies to Evaluate the Kinetics of Donor Chimerism in Different Cell Subsets after Double-Cord-Blood Transplantation in the NOD/SCID Model
Scientists conducted studies in a mouse model to develop a new analytic method using anti-human HLA Class I allele-specific monoclonal antibodies in flow cytometry. Single-cord-blood transplantation or double-cord-blood transplantation from HLA-mismatched donors was performed in NOD/SCID mice. [Transfusion] Abstract

Cord-Blood Hematopoietic Stem-Cell Transplantation Confers an Increased Risk for Human Herpesvirus-6-Associated Acute Limbic Encephalitis: A Cohort Analysis
Researchers found that patients receiving unrelated cord-blood transplantation have increased risk for post-transplantation acute limbic encephalitis and greater morbidity from this disease. [Biol Blood Marrow Transplant] Abstract

Isolation and Characterization of Wharton’s Jelly Derived Multipotent Mesenchymal Stromal Cells Obtained from Bovine Umbilical Cord and Maintained in a Defined Serum-Free Three-Dimensional System
The authors described for the first time the isolation and characterization of bovine-derived umbilical cord Wharton’s jelly cells in a serum free condition and maintenance of primitive mesenchymal phenotype. [BMC Biotechnol] Abstract

Stem Cell-Based Photodynamic Therapy
Investigators have used gaussia luciferase containing supernatant from culturing neural stem cells to perform in vitro photodynamic therapy of murine melanoma cells, and rat umbilical cord matrix-derived stem cells to perform in vivo PDT of lung melanomas in C57BL/6 mice. [Photochem Photobiol Sci] Abstract

Complimentary Wallchart: Human Hematopoietic Progenitors. Request Your Copy Today.

INDUSTRY NEWS

Dr. Timothy Cripe of Nationwide Children’s Hospital Appointed to a Committee of the Food and Drug Administration
Timothy Cripe, MD, PhD was appointed a member of the Cellular, Tissue and Gene Therapy Advisory Committee which reports to the Food and Drug Administration. [Nationwide Children’s Hospital]
Press Release

UM’s Interdisciplinary Stem Cell Institute Awarded $10 Million Grant from Starr Foundation
The grant will support the University of Miami (UM) Miller School of Medicine’s Interdisciplinary Stem Cell Institute in broadening its preclinical and clinical research on stem cells, and help accelerate its pipeline of translational research and programs for a wide range of debilitating conditions. [University of Miami Miller School of Medicine] Press Release

First Fellowships Awarded in New Canadian Stem Cell and Regenerative Medicine Research Program
The first two postdoctoral research fellowships of a new program to promote stem cell research in Canada were announced by the program’s sponsors, Canada’s Stem Cell Network and Pfizer. [Stem Cell Network] Press Release

Stem Cell Society Singapore Symposium 2012: Stem Cell Based Therapy

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW International Conference on Tissue Science and Engineering
October 1-3, 2012
Chicago, United States

Visit
our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Business Development Manager – Stem Cell (SynGen Inc.)

Controller (SynGen Inc.)

Director: Regulatory Affairs (SynGen Inc.)

Manufacturing Manager (SynGen Inc.)

Development Scientist – Cell Therapy (GE Healthcare)

Group Leaders, Principle Scientists – Stem Cell Clinical Product R&D (Shanghai Hengrui Pharmaceuticals Co., Ltd)


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