Volume 4.23 | Jun 14

Cord Blood News 4.23 June 14, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Human T-Lymphoid Progenitors Generated in a Feeder-Cell-Free DL-4 Culture System Promote T-Cell Reconstitution in NOD/SCID/γc−/− Mice
Researchers described the development of a new culture system based on the immobilized Notch ligand Delta-like-4 (DL-4). Culture of human CD34+ cord blood cells in this new DL-4 system enabled the in vitro generation of large amounts of T-cell progenitor cells that displayed the phenotypic and molecular signatures of early thymic progenitors and had high T lymphopoietic potential. [Stem Cells] Abstract

Technical Bulletin: Assays For Cord Blood
PUBLICATIONS (Ranked by impact factor of the journal)

The Autoimmunity Associated BLK Haplotype Exhibits Cis-Regulatory Effects on mRNA and Protein Expression that Are Prominently Observed in B Cells Early in Development
The authors showed that in primary human B lymphocytes, cis-regulatory effects of disease associated SNPs in the gene B lymphocyte kinase (BLK) are restricted to naïve and transitional B cells. Cis-regulatory effects are not observed in adult B cells in later stages of differentiation. Allelic expression bias was also identified in primary human T cells from adult peripheral and umbilical cord blood, thymus and tonsil, although mRNA levels were reduced compared with B cells. [Hum Mol Genet] Abstract

Human Thymic MR1-Restricted MAIT Cells Are Innate Pathogen-Reactive Effectors that Adapt following Thymic Egress
Human mucosal-associated invariant T (MAIT) cells express the semi-invariant T-cell receptor Vα7.2 and are restricted by the major histocompatibility complex-Ib molecule MR1. Investigators evaluated the function of Vα7.2+ T cells from the thymus, cord blood, and peripheral blood. [Mucosal Immunol] Abstract

The Role of WDR5 in Silencing Human Fetal Globin Gene Expression
In human bone marrow erythroid progenitor cells, levels of WDR5 were highly enriched on the γ-promoter relative to levels on other globin promoters and compared to the γ-promoter in cord blood erythroid progenitors, suggesting that WDR5 is important in the developmental globin gene expression program. [Haematologica] Abstract | Full Article

The Homing of Human Cord Blood Stem Cells to Sites of Inflammation: Unfolding Mysteries of a Novel Therapeutic Paradigm for Glioblastoma Multiforme
Results indicated that multiple cytokines are involved in recruitment of human umbilical cord blood mesenchymal stem cells (hUCBSC) toward glioma stem cells, and that hUCBSC are a potential candidate for glioma therapy. [Cell Cycle] Abstract

A Dose-Dependent Function of Follicular Fluid on the Proliferation and Differentiation of Umbilical Cord Mesenchymal Stem Cells (MSCs) of Goat
Researchers isolated MSCs from the fetal umbilical cord of goat and investigated their multipotency of differentiation into germ cells in vitro, in the presence of 0-20% bovine follicular fluid. [Histochem Cell Biol] Abstract

Effect of AGM and Fetal Liver-Derived Stromal Cell Lines on Globin Expression in Adult Baboon (P. anubis) Bone Marrow-Derived Erythroid Progenitors
Adult baboon bone marrow and human cord blood CD34+ progenitors were grown in methylcellulose, liquid media, and in co-culture with stromal cell lines derived from different developmental stages in identical media supporting erythroid differentiation to examine the effect of the micro-environment on globin gene expression. [PLoS One] Full Article

Immune Recovery in Adult Patients following Myeloablative Dual Umbilical Cord Blood, Matched Sibling, and Matched Unrelated Donor Hematopoietic Cell Transplantation
Compared to HLA-identical matched sibling and unrelated donor adult hematopoietic cell transplantation recipients, quantitative lymphoid recovery in umbilical cord blood transplant recipients is slower in the first three months, but these differences disappeared by 6-12 months following transplantation. [Biol Blood Marrow Transplant] Abstract

SPARC Promotes the Development of Erythroid Progenitors
CD34+ cells from umbilical cord blood were isolated, and the effect of secreted protein acidic and rich in cysteine (SPARC) on human erythropoiesis was assessed by colony formation assay and erythroid differentiation culture. [Exp Hematol] Abstract

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INDUSTRY NEWS

Cryo-Save Begins Long-Term Relationship with Catholic University of Holy Heart
A new collaboration has begun between Cryo-Save and Università Cattolica del Sacro Cuore. The partnership aims at promoting and improving knowledge on the cryopreservation of mesenchymal stem cells from the umbilical cord tissue. [Cryo-Save AG] Press Release

Saneron CCEL Therapeutics, Inc. Announces Clinical Supply and Research Collaboration Agreement with Texas Cord Blood Bank
Saneron CCEL Therapeutics, Inc. and the Texas Cord Blood Bank announced a clinical supply and research collaboration agreement to provide mononuclear cells from clinical grade cord blood for use in regenerative medicine research related to potential new Alzheimer’s, ALS and stroke therapies. The Texas Cord Blood Bank is a division of the South Texas Blood & Tissue Center. [South Texas Blood & Tissue Center]
Press Release

TeSR™-E8™ and STEMdiff™: New Products to Advance Research on Human Pluripotent Stem Cells
STEMCELL Technologies Inc. announced its plans to release a series of new products to advance research and translational applications for human pluripotent stem cells. [STEMCELL Technologies Inc.]
Press Release

BGI, GE Healthcare Team Up on Pioneering Stem Cell Science Projects
General Electric (GE) Healthcare and BGI jointly announced a pioneering multi-year research collaboration in stem cell science. [BGI] Press Release

Stem Cell Society Singapore Symposium 2012: Stem Cell Based Therapy

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 13th Czech and Slovak Conference of Laboratory Hematology
September 5-6, 2012
Brno, Czech Republic

NEW 16th Czech and Slovak Congress of Hematology and Transfusion Medicine
September 6-8, 2012
Brno, Czech Republic

Visit
our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Business Development Manager – Stem Cell (SynGen Inc.)

Controller (SynGen Inc.)

Director: Regulatory Affairs (SynGen Inc.)

Manufacturing Manager (SynGen Inc.)

Chief Scientific Officer (SynGen Inc.)

Development Scientist – Cell Therapy (GE Healthcare)

Group Leaders, Principle Scientists – Stem Cell Clinical Product R&D (Shanghai Hengrui Pharmaceuticals Co., Ltd)

Stem Cell Therapy Scientist (Paramount Recruitment)


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