Volume 4.28 | Jul 19

Cord Blood News 4.28 July 19, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Neurons Derived from Cord Blood Cells May Represent New Therapeutic Option
Scientists have found a new way - using a single protein, known as a transcription factor - to convert cord blood cells into neuron-like cells that may prove valuable for the treatment of a wide range of neurological conditions. [Press release from the Salk Institute for Biological Studies discussing online prepublication in the Proceedings of the National Academy of Sciences, USA] Press Release | Abstract

Visit the Human Immunology Portal for cord blood protocols, tips and other resources
PUBLICATIONS (Ranked by impact factor of the journal)

Ex Vivo Expansion of Normal and Chronic Myeloid Leukemic Stem Cells without Functional Alteration Using a NUP98HOXA10homeodomain Fusion Gene
Researchers compared the number of long-term culture-initiating cells present in cultures of lenti-NUP98HOXA10homeodomain versus control virus-transduced CD34+ cells originally isolated from human cord blood and chronic phase chronic myeloid leukemia patients. [Leukemia] Abstract

Cord Blood-Hematopoietic Stem Cell Expansion in Three-Dimensional Fibrin Scaffolds with Stromal Support
Four different three-dimensional biomaterial scaffolds were tested for freshly isolated cord blood-CD34+ cell expansion in the presence of efficient exogenous cytokine supplementation and umbilical cord-mesenchymal stem cells. [Biomaterials] Abstract

Dynamics of Human Prothymocytes and Xenogeneic Thymopoiesis in Hematopoietic Stem Cell-Engrafted Nonobese Diabetic-SCID/IL-2rγnull Mice
To model the developmental pattern of human prothymocytes and thymopoiesis, researchers used NOD-scid/γc-/- mice grafted with human umbilical cord blood CD34+ hematopoietic progenitor cells. [J Immunol] Abstract

Co-Transplantation of Ex Vivo Expanded Progenitors with Non-Expanded Cord Blood Cells Improves Platelet Recovery
The authors found that human platelet recovery and short term bone marrow engraftment can be efficiently improved by the co-transplantation of megakaryocyte primed umbilical cord blood cells with non-expanded hematopoietic stem and progenitor cells in a murine transplantation model. [Stem Cells Dev] Abstract

Mesoderm-Derived Stem Cells: The Link Between the Transcriptome and Their Differentiation Potential
Researchers compared the global gene expression profiles of four mesoderm-derived stem cell populations: human adipose tissue-derived stromal cells, human bone marrow-derived stromal cells, human (fore)skin-derived precursor cells, and human Wharton's jelly-derived mesenchymal stem cells. [Stem Cells Dev] Abstract

Glioma Stem Cell Invasion through Regulation of the Interconnected ERK, Integrin α6 and N-Cadherin Signaling Pathway
Results demonstrated the dynamic interplay among extracellular signal-regulated kinase (ERK), N-cadherin and integrin α6 in glioma stem cell (GSC) invasion and also revealed the therapeutic potential of human umbilical cord blood stem cells in treating the molecular crosstalk observed in GSC-regulated invasion. [Cell Signal] Abstract

Neuroglial Activation and Cx43 Expression Are Reduced Upon Transplantation of Human Umbilical Cord Blood Cells After Perinatal Hypoxic-Ischemic Injury
Scientists investigated glial responses like inflammation and astrocytic activation in a rat model of neonatal hypoxic-ischemic brain injury and characterized changes of these parameters upon transplantation of human umbilical cord blood cells. [Brain Res] Abstract

A Non-Rotational, Computer-Controlled Suspension Bioreactor for Expansion of Umbilical Cord Blood Mononuclear Cells
The proliferation and differentiation characteristics of umbilical cord blood mononuclear cells were examined in a non-rotational suspension bioreactor with a fishtail mixer. [Biotechnol Lett] Abstract

Learn more about the new smartphone app for human blood cell frequencies

INDUSTRY NEWS

Americord Registry Backs Up Its Product Offering with the First Ever $80,000 Cord Blood Quality Product Guarantee
Americord is continuing to up the ante with the recent launch of its cord tissue banking and with its Quality Guarantee announcement. If a cord blood client's stored cord blood is used in a stem cell transplant and fails to engraft, Americord will pay up to $80,000 to defray the cost of the procurement of an alternate stem cell source if medically indicated. [Americord Registry LLC] Press Release

Mediware Acquisition Gains Market Momentum by Adding Major New Customer
Mediware Information Systems, Inc. announced that the global cord blood therapeutic company, Stemcyte, has licensed the Transtem cell therapy software to automate manufacturing processes associated with the company’s cord blood collection and storage business. [Mediware Information Systems, Inc.] Press Release

World Cord Blood Congress 2012

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW The 2nd Midwest Conference on Stem Cell Biology and Therapy
October 5-7, 2012
Rochester, United States

Visit
our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientist - hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist - Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist - Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist - Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Associate - Chemistry (STEMCELL Technologies, Inc.)

Research Associate - Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist - Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist - Media Development (STEMCELL Technologies, Inc.)

Research Technologist - Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Group Leaders, Principle Scientists - Stem Cell Clinical Product R&D (Shanghai Hengrui Pharmaceuticals Co., Ltd)

Stem Cell Therapy Scientist (Paramount Recruitment)

BMS Specialist/BMS Advanced Specialist (NHS Blood and Transplant)

Clinical Lab Scientist - Cord Blood (Cardinal Glennon Children's Medical Center)


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