Volume 4.33 | Aug 23

Cord Blood News 4.33 August 23, 2012
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Umbilical Cord Blood-Derived Aldehyde Dehydrogenase-Expressing Progenitor Cells Promote Recovery from Acute Ischemic Injury
The authors used fluorescence activated cell sorting to purify a rare population of umbilical cord blood cells with high aldehyde dehydrogenase activity (ALDHhi). After induction of acute unilateral hindlimb ischemia by femoral artery ligation, transplantation of ALDHhi cells significantly enhanced the recovery of perfusion in ischemic limbs. [Stem Cells] Abstract

Atlas of Hematopoietic Colonies from Cord Blood
PUBLICATIONS (Ranked by impact factor of the journal)

Analysis of Incidence, Risk Factors and Clinical Outcome of Thromboembolic and Bleeding Events in 431 Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Investigators retrospectively analyzed data from 431 allogeneic transplantation recipients to identify the incidence, risk factors and mortality due to thrombosis and bleeding. [Haematologica] Abstract | Full Article

Human Amniotic Fluid Stem Cell Injection Therapy for Urethral Sphincter Regeneration in an Animal Model
Researchers investigated whether periurethral injection of human amniotic fluid stem cells can restore urethral sphincter competency in a mouse model. [BMC Med] Abstract | Full Article | Press Release

Human Umbilical Cord Stem Cell Encapsulation in Novel Macroporous and Injectable Fibrin for Muscle Tissue Engineering
Researchers aimed to seed human umbilical cord mesenchymal stem cells in a fibrin hydrogel containing fast-degradable microbeads to create macropores to enhance cell viability and to investigate the encapsulated cell proliferation and myogenic differentiation for muscle tissue engineering. [Acta Biomater] Abstract

Pkb/Akt1 Mediates Wnt/GSK3β/β-Catenin Signaling-Induced Apoptosis in Human Cord Blood Stem Cells Exposed to Organophosphate Pesticide Monocrotophos
Inhibition mechanisms of protein kinase B (Pkb)/Akt and its consequences on related cell signaling were investigated in human umbilical cord blood stem cells exposed to monocrotophos. [Stem Cells Dev] Abstract

Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors
Investigators report highly optimized four-factor reprogramming of lineage-committed cord blood myeloid progenitors with bulk efficiencies of ~50% in purified episome-expressing cells. The efficient conversion of mature myeloid populations into NANOG+TRA-1-81+ human induced pluripotent stem cells (iPSCs) was mediated by synergies between hematopoietic growth factor, stromal activation signals, and episomal Yamanaka factor expression. [PLoS One] Full Article | Press Release

Mesenchymal Stromal Cells of Human Umbilical Cord Wharton's Jelly Accelerate Wound Healing by Paracrine Mechanisms
Human umbilical cord perivascular cells (HUCPVC) were isolated, and their proliferation rate, marker expression and multilineage differentiation potential determined. HUCPVC or their conditioned medium were injected into the excisional wound of a mouse splinted-wound model. The effects of the treatment on wound closure were examined by morphohistochemical and gene expression analyses. [Cytotherapy] Abstract

Insulin-Like Growth Factor-I Regulates the Neonatal Immune Response in Infection and Maturation by Suppression of IFN-γ
Immunosuppression by insulin-like growth factor-I (IGF-I) might be a key regulator of neonatal immune responses in infection and maturation. However, information on IGF-I serum levels, IGF-I-receptor and effects on functional properties of neonatal immune cells is scarce. Neonatal cord blood samples were stimulated with anti-CD3/anti-CD28, PMA/ionomycin or LPS in a whole-blood assay, while IGF-I serum levels and IGF-I receptor expression were assessed. [Cytokine] Abstract

Stemness of Human Wharton's Jelly Mesenchymal Cells Is Maintained by Floating Cultivation
Researchers characterized and maintained the stemness characteristics of mesenchymal stem cells for Wharton's jelly. Wharton's jelly cells were isolated, adhered to culture plates, and characterized for stem cell and surface markers expression. [Cell Reprogram] Abstract

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Based on your feedback, we've added a Reviews section to Cord Blood News
Enhancing Engraftment of Cord Blood Cells via Insight into the Biology of Stem/Progenitor Cell Function
This review provides information about the general field of cord blood (CB) transplantation and about studies that focus on regulation of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) by CD26/DPPIV, SDF-1/CXCL12, the Rheb2-mTOR pathway, SIRT1, DEK, cyclin-dependent kinase inhibitors, and cytokines/growth factors. Cryopreservation of CB HSCs and HPCs is also briefly discussed. [Ann N Y Acad Sci] Abstract

Autism and Cord Blood Stem Cells: FDA Gives Green Light for Groundbreaking Clinical Trial
Sutter Neuroscience Institute and Cord Blood Registry are launching the first FDA- approved clinical trial to assess the use of a child’s own cord blood stem cells to treat select patients with autism. [Cord Blood Registry] Press Release

ThermoGenesis Announces AXP® Product Purchase and Distribution Agreement with Golden Meditech Holdings Limited
ThermoGenesis Corp. announced that it has signed a wide ranging product purchase and distribution agreement for its AXP® AutoXpress® (AXP) System used for the processing of stem cells from cord blood with Golden Meditech Holdings Limited. [ThermoGenesis Corp.] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 3rd International Conference on Stem Cells and Cancer (ICSCC-2012): Proliferation, Differentiation and Apoptosis
October 27-30, 2012
New Delhi, India

our events page to see a complete list of events in the cord blood community.

Scientist - Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Technologist - Media Development (STEMCELL Technologies, Inc.)

Research Technologist - Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Stem Cell Therapy Scientist (Paramount Recruitment)

Clinical Lab Scientist - Cord Blood (Cardinal Glennon Children's Medical Center)

Postdoctoral Position - Molecular Biology (Faculty of Informatics, Masaryk University)

Postdoctoral Position - Stem Cell Research (Connecticut Children's Medical Center, University of Connecticut)

Postdoctoral Fellow - Stem Cell Biology and Developmental Hematopoiesis (Mount Sinai School of Medicine)

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