Volume 4.35 | Sep 6

Cord Blood News 4.35 September 6, 2012
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Generation and Genetic Engineering of Human Induced Pluripotent Stem Cells Using Designed Zinc Finger Nucleases
Zinc finger nuclease-mediated gene targeting was used to generate both single allele CCR5-modified human induced pluripotent stem cells (hiPSCs) and biallele CCR5-modified hiPSCs from human lung fibroblasts and human primary cord blood mononuclear cells by site-specific insertion stem cell transcription factor genes flanked by LoxP sites into the endogenous CCR5 locus. [Stem Cells Dev] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

HLA-C-Dependent Prevention of Leukemia Relapse by Donor Activating KIR2DS1
Researchers assessed clinical data, HLA genotyping results, and donor cell lines or genomic DNA for 1277 patients with acute myeloid leukemia who had received hematopoietic stem-cell transplants from unrelated donors matched for HLA-A, B, C, DR, and DQ or with a single mismatch. [N Engl J Med] Abstract

Kruppel Like Factor 7 Overexpression Suppresses Hematopoietic Stem and Progenitor Cell Function
Results suggest that Kruppel like factor 7 is not required for normal hematopoietic stem and progenitor function, but increased expression, as seen in a subset of lymphoid leukemia, inhibits myeloid cell proliferation and promotes early thymocyte survival. [Blood] Abstract

CADASIL Mutations and shRNA Silencing of NOTCH3 Affect Actin Organization in Cultured Vascular Smooth Muscle Cells
Researchers analyzed NOTCH3 expression and morphology of actin cytoskeleton in genetically genuine cultured human cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) vascular smooth muscle cells (VSMCs) derived from different organs, and in control VSMCs with short hairpin RNA (shRNA)-silenced NOTCH3. [J Cereb Blood Flow Metab] Full Article

Vitamin D Improves the Angiogenic Properties of Endothelial Progenitor Cells
Endothelial colony forming cells (ECFCs) were obtained and cultured from cord blood, and characterized by immunocytochemistry and flow cytometry. Proliferation, total length of tubule formation on Matrigel, expression of VEGF mRNA and proMMP-2 activity were assessed after treatment of ECFCs with vitamin D3. [Am J Physiol Cell Physiol] Abstract

SALL4 Is a Key Transcription Regulator in Normal Human Hematopoiesis
Investigators found that SALL4 is a key regulator in normal human hematopoiesis and the mechanism of its function is at least in part through the HOXA9. Future study will determine whether modulating the SALL4/HOXA9 pathway can be used in cellular therapy such as cord blood expansion and/or myeloid engraftment. [Transfusion] Abstract

Differential Expression of HSP90α and Heme Oxygenase in Cord Blood RBC during Preeclampsia
Researchers analyzed the regulation relationship between HSP90α and HO-2 in cord blood RBC during preeclampsia. [Toxicol Mech Methods] Abstract

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REVIEWS
Umbilical Cord Blood Graft Enhancement Strategies: Has the Time Come to Move These into the Clinic?
Researchers discuss promising ex vivo manipulations to enhance cord blood engraftment capacity such as culture of umbilical cord blood cells with stimulatory cytokines and growth factors, mesenchymal cells, Notch ligand, copper chelators, prostaglandins, complement components, nicotinamide and CD26/DPPIV inhibitors. [Bone Marrow Transplant] Abstract
INDUSTRY NEWS

ThermoGenesis Announces New Integrated Distribution Strategy for Cord Blood Products in Western Europe
ThermoGenesis Corp. announced a new integrated distribution agreement in Europe with Concessus for its cord blood products – the AXP® AutoXpress® System and BioArchive® System. [ThermoGenesis Corp.] Press Release

$36.4 Million Funds for Radiation Syndrome Cell Therapy
Cellerant Therapeutics won a $36.4 million Biomedical Advanced Research and Development Authority grant to support advanced development of allogeneic cell-based therapy CLT-008, for the treatment of acute radiation syndrome. CLT-008 is an off-the-shelf cryopreserved cell-based therapy comprising human myeloid progenitor cells derived from hematopoietic stem cells. [Genetic Engineering & Biotechnology News]
Press Release

Third Critically Ill Patient Successfully Treated with Pluristem’s PLX Cells Under Compassionate Use
Pluristem Therapeutics, Inc. announced that the Company’s Placental eXpanded (PLX) cells were successfully administered to a third patient in Hadassah Medical Center; thus, a series of three lifesaving compassionate use treatments were completed. [Pluristem Therapeutics, Inc.] Press Release

STEMSOFT Welcomes New EMEA Sales Director
STEMSOFT Software, Inc. (STEMSOFT), the leading provider of software solutions for the cell therapy and transplant community, is pleased to welcome Isabel Feys on board as the new Director of Sales for the EMEA area. [STEMSOFT Software, Inc.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW International Society of Differentiation Conference: Stem Cells, Development and Regulation
November 5-8, 2012
Amsterdam, Netherlands

NEW BIT’s 3rd Annual World Congress of Molecular & Cell Biology
June 14-16, 2013
Suzhou, China

Visit
our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Stem Cell Therapy Scientist (Paramount Recruitment)

Clinical Lab Scientist – Cord Blood (Cardinal Glennon Children’s Medical Center)

Postdoctoral Position – Molecular Biology (Faculty of Informatics, Masaryk University)

Research Associate – Quality Assurance (University of California)


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