Volume 4.39 | Oct 4

Cord Blood News 4.39 October 4, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Cord Blood T Cells Retain Early Differentiation Phenotype Suitable for Immunotherapy after TCR Gene Transfer to Confer EBV Specificity
Researchers utilized cord blood (CB) lymphocytes, which comprise mainly naive cells, for transducing Epstein-Barr virus (EBV)-specific T cell receptors (TCR). Comparable TCR expression was achieved in adult and CB cells, but the latter expressed an earlier differentiation profile. [Am J Transplant] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

IL10 Polymorphisms Influence Neonatal Immune Responses, Atopic Dermatitis, and Wheeze at Age Three Years
Researchers hypothesized that IL10 single nucleotide polymorphisms (SNPs) are associated with decreased regulatory T cell numbers, TH2-skewed immune responses, and decreased IFN-γ levels in cord blood parallel with increased proinflammatory markers, subsequently leading to increased atopic diseases until three years. [J Allergy Clin Immunol] Abstract

Memory CD4+CCR5+ T Cells Are Abundantly Present in the Gut of Newborn Infants to Facilitate Mother-to-Child Transmission of HIV-1
Scientists demonstrated that in the human fetal and infant gut mucosa there is already a large subset of mucosal memory CD4+CCR5+ T cells with predominantly a Th1 and Th17 phenotype. Using next-generation sequencing of the T-cell-receptor β chain, clonally expanded T cells, as a hallmark for memory development predominated in the gut mucosa (30%), while few were found in lymph node (1%) and none in cord blood (0%). [Blood] Abstract

Renoprotective Effect of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Immunodeficient Mice Suffering from Acute Kidney Injury
Researchers examined whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) could improve renal function in nonobese diabetic-severe combined immune deficiency mice suffering from acute kidney injury, and investigated the mechanism(s) for hUC-MSCs to improve renal function in this xenogeneic model. [PLoS One] Full Article

Gene Expression Profiling Identifies HOXB4 as a Direct Downstream Target of GATA-2 in Human CD34+ Hematopoietic Cells
Investigators identified HOXB4 as a downstream target of GATA-2 based on expression profiling with human cord blood-derived CD34-positive cells infected with control or GATA-2 lentiviral shRNA. [PLoS One]
Full Article

Stability of T Cell Phenotype and Functional Assays following Heparinized Umbilical Cord Blood Collection
Using multiparameter flow cytometry, investigators tested the effect of collection technique and length of time prior to umbilical cord mononuclear cell isolation on T cell phenotype and function, with the goal of creating a standardized operating procedure for a multicenter investigation. [Cytometry A] Abstract

The Effect of Cellular Senescence on the Albumin Permeability of Blood-Derived Endothelial Cells
Scientists tested the hypotheses that endothelial cells derived from human umbilical cord blood (hCB-ECs) exhibited low permeability which increased as the hCB-ECs age and undergo senescence and that the change in permeability of hCB-ECs is due to changes in tight junction protein localization and the activity of Epac1. [Am J Physiol Heart Circ Physiol] Abstract

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Prevent Diabetic Renal Injury through Paracrine Action
Researchers examined the renoprotective effect of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) in diabetes. NRK-52E cells were utilized to determine the paracrine effect of hUCB-MSC. [Diabetes Res Clin Pract] Abstract

Hearing Restoration in a Deaf Animal Model with Intravenous Transplantation of Mesenchymal Stem Cells Derived from Human Umbilical Cord Blood
Researchers aimed to confirm the effect of transplantation of human umbilical cord blood mesenchymal stem cells on hearing restoration in a sensorineural hearing loss animal model. [Biochem Biophys Res Commun] Abstract

Compromised Hematopoiesis and Increased DNA Damage following Non-Lethal Ionizing Radiation of a Human Hematopoietic System Reconstituted in Immunodeficient Mice
The authors transplanted cord blood CD34+ hematopoietic stem and progenitor cells (HSPCs) into NOD/Shi-scid, IL2Rγnull (NOG) mice irradiated with 2.0 Gy via tail veins. At the twelfth week after transplantation, the NOG mice were irradiated with 0, 0.5, 1.0, 2.0, or 4.0 Gy, and the radiation effects on human HSPCs in vivo were evaluated. [Int J Radiat Biol] Abstract

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INDUSTRY NEWS

Cord Blood America, Inc. Announces Sale of Stake in stellacure, GmbH to Medivision
Cord Blood America, Inc. announced that it has sold its 51% stake in its German subsidiary, stellacure, GmbH to Medivision mbH, headquartered in Hamburg, Germany, for approximately 33,649 Euros or $43,420. [Cord Blood America, Inc.] Press Release

China Cord Blood Corporation Announces Completion of $50 Million Convertible Note Financing with Golden Meditech
China Cord Blood Corporation announced that it has successfully completed the previously announced $50 million convertible note financing with Golden Meditech Holdings Limited. [China Cord Blood Corporation] Press Release

Pluristem Selects Fisher BioServices as Worldwide Dispatch Distributor of Its PLX Cell Therapies to Serve Global Clinical Studies
Pluristem Therapeutics, Inc. announced it has selected Fisher BioServices, Inc. as worldwide dispatch distributor of its off-the-shelf PLacental eXpanded (PLX) cells. Fisher BioServices will provide cryogenic storage and distribution of Pluristem’s PLX cells for its clinical trials and preclinical sites around the world. [Pluristem Therapeutics, Inc.] Press Release

New Edition of Definitive (Two-Volume) Resource in Stem Cells Released
Advanced Cell Technology, Inc. announced that its chief scientific officer, Robert Lanza, M.D. and Anthony Atala, M.D. have released the second edition of Handbook of Stem Cells (Academic Press/Elsevier), the widely-recognized definitive resource in the field of stem cells. [Advanced Cell Technology, Inc.]
Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Stem Cells and Metabolism
November 5-6, 2012
La Jolla, United States

View our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

Clinical Lab Scientist – Cord Blood (Cardinal Glennon Children’s Medical Center)

Research Associate – Quality Assurance (University of California)

Postdoctoral Position in Mouse Stem Cell Biology (University of Alabama at Birmingham)

Postdoctoral Fellow in Stem Cells and Cancer (Tsinghua University)

Postdoctoral Position in Mouse Developmental Biology (Lund Stem Cell Center, Lund University)


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