Volume 4.42 | Oct 25

Cord Blood News 4.42 October 25, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
PI3K-PKB Hyperactivation Augments Human Plasmacytoid Dendritic Cell Development and Function
Researchers investigated the role of the PI3K-PKB-mTOR axis in human plasmacytoid dendritic cells (pDC) development, survival and function. In vitro pDC generation from human cord blood-derived CD34+ hematopoietic progenitors was reduced by pharmacological inhibition of PI3K, PKB or mTOR activity and peripheral blood pDC required PI3K-PKB-mTOR signaling to survive. [Blood] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Hematopoietic Colony Formation from Human Growth Factor-Dependent TF1 Cells and Human Cord Blood Myeloid Progenitor Cells Depends on Shp2 Phosphatase Function
To verify the role of Shp2 phosphatase function in human hematopoietic cell development, human cord blood CD34+ cells were transduced with a leukemia-associated phosphatase gain-of-function Shp2 mutant or with a phosphatase dead Shp2 mutant, which indicated that increased phosphatase function enhanced, while decreased Shp2 phosphatase function reduced, human cord blood-derived colonies. [Stem Cells Dev] Abstract

Factors with an Impact on Chimerism Development and Long-Term Survival after Umbilical Cord Blood Transplantation
Researchers performed a retrospective single-center analysis of 50 umbilical cord blood transplantations performed from 2001 to 2010, including 37 single and 13 double umbilical cord blood transplantations. [Transplantation] Abstract

Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections
Researchers hypothesized that cure of HIV infections by hematopoietic cell transplantation can be accomplished using umbilical cord blood stem cells obtained from a modestly sized inventory of cryopreserved CCR5-Δ32/Δ32 cord blood units. [Biol Blood Marrow Transplant] Abstract

Immune Reconstitution Kinetics as an Early Predictor for Mortality Using Various Hematopoietic Stem Cell Sources in Children
Scientists investigated differences in immune reconstitution with different cell sources and the association between the kinetics of immune reconstitution and mortality. Lymphocyte reconstitution in the first three months after hematopoietic stem cell transplantation (HSCT) was studied in relation to mortality in three HSCT-groups: matched sibling bone marrow, unrelated bone marrow, and unrelated cord blood. [Biol Blood Marrow Transplant] Abstract

MiR-16 Inhibits the Proliferation and Angiogenesis-Regulating Potential of Mesenchymal Stem Cells in Severe Pre-Eclampsia
MicroRNA(miR)-16-over-expressed decidua-derived mesenchymal stem cells reduced the ability of human umbilical vein endothelial cells to form blood vessels and the migration of the trophoblast cells. [FEBS J] Abstract

Immune Reconstitution after Combined Haploidentical and Umbilical Cord Blood Transplantation
Overall, immune reconstitution after haplo-cord transplantation was similar to that seen after cord blood transplantation, despite infusion of much lower cord blood cell dose. [Leuk Lymphoma] Abstract

Repair and Regeneration of Skin Injury by Transplanting Microparticles Mixed with Wharton’s Jelly and MSCs from the Human Umbilical Cord
Researchers explored a new strategy for treating skin wounds. A mixture of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells, Wharton’s jelly, and skin microparticles were transplanted to 10-mm diameter, full-thickness, middorsal, excisional skin wounds of mice. [Int J Low Extrem Wounds] Abstract

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INDUSTRY NEWS

StemBioSys and STBTC’s GenCure Announce Human Umbilical Cord Blood Stem Cell Research Collaboration Agreementt
The South Texas Blood & Tissue Center (STBTC), through its GenCure affiliate, has established a research collaboration agreement with San Antonio-based StemBioSys, Inc. to provide mononuclear cells from clinical grade human umbilical cord blood to StemBioSys for research and development use. [South Texas Blood & Tissue Center] Press Release

Association Establishes the AABB Center for Cellular Therapies
AABB (formerly the American Association of Blood Banks) has established the AABB Center for Cellular Therapies, a functional unit within AABB that will focus on activities designed to foster patient safety and responsible innovation in the cellular therapy and regenerative medicine field. [AABB] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW STEM 2013: 9th Annual Conference – Society for Regenerative Medicine & Tissue Engineering
January 31-February 1, 2013
Bangalore, India

View our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

Product Quality Scientist (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Research Associate – Quality Assurance (University of California)

Postdoctoral Position in Mouse Stem Cell Biology (University of Alabama at Birmingham)

Postdoctoral Fellow in Stem Cells and Cancer (Tsinghua University)

Research Associate I – The Stem Cell Therapeutics and Vascular Biology Lab (Blood Systems Research Institute)

Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)


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