Volume 4.43 | Nov 1

Cord Blood News 4.43 November 1, 2012
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension
Researchers aimed to investigate the paracrine mechanisms by which mesenchymal stromal cells (MSCs) are protective in hypoxic pulmonary hypertension. MSC-derived exosomes (MEX) produced by human umbilical cord MSCs inhibited signal transducer and activator of transcription 3 signaling in isolated human pulmonary artery endothelial cells demonstrating a direct effect of MEX on hypoxic vascular cells. [Circulation]
Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

The Potential Role of Epigenetics on Multipotent Cell Differentiation Capacity of Mesenchymal Stromal Cells
Investigators were interested in understanding how differences from human bone marrow (BM)-derived mesenchymal stromal cells (MSCs) might yield insights into MSC biology. They found that human umbilical cord perivascular cells (HUCPVCs) exhibited increased telomerase activity and longer telomeres compared with BM-MSCs. They also observed enhanced expression of the pluripotency factors OCT4, SOX2 and NANOG in HUCPVCs. [Stem Cells] Abstract

Generating CK19-Positive Cells with Hair-Like Structures from Wharton’s Jelly Mesenchymal Stromal Cells
Researchers showed for the first time that they can generate cytokeratin 19-positive cells and hair-like structures from Wharton’s jelly mesenchymal stromal cells (WJMSCs) in vitro using two separate methodologies that utilize osteogenic media to induce WJMSCs to undergo osteogenic differentiation. [Stem Cells Dev] Abstract

Human Cord Blood Derived Immature Basophils Show Dual Characteristics, Expressing Both Basophil and Eosinophil Associated Proteins
In order to obtain transcriptionally active immature basophils for analysis of their transcriptome, umbilical cord blood cells were cultured in the presence of interleukin-3 for nine days and basophils were enriched by removing non-basophils using magnetic cell sorting. [PLoS One] Full Article

An Integrative Computational Systems Biology Approach Identifies Differentially Regulated Dynamic Transcriptome Signatures which Drive the Initiation of Human T Helper Cell Differentiation
The authors studied transcriptional dynamics of human umbilical cord blood T helper (Th) cells cultured in absence and presence of cytokines promoting Th1 or Th2 differentiation. [BMC Genomics]
Abstract | Full Article

Contrasting Effects of Vasculogenic Induction Upon Biaxial Bioreactor Stimulation of Mesenchymal Stem Cells and Endothelial Progenitor Cells Cocultures in 3D Scaffolds Under In Vitro and In Vivo Paradigms for Vascularized Bone Tissue Engineering
Researchers demonstrated the effect of biomechanical stimulation on vasculogenic and bone-forming capacity of umbilical-cord-blood endothelial progenitor cells and human fetal bone-marrow-derived mesenchymal stem cells seeded within macroporous scaffolds and cocultured dynamically in a biaxial bioreactor. [Tissue Eng Part A] Abstract

Rapid and Complete Reconstitution of Autologous Hemopoiesis after Cord Blood Infusion in Treatment-Naive Patients with Severe Aplastic Anemia Receiving High-Dose Cyclophosphamide/ATG Therapy
Infusion of cord blood after high-dose cyclophosphamide/ATG resulted in a rapid autologous hematological recovery and a high response rate in treatment-naive patients with severe aplastic anemia. [Eur J Haematol] Abstract

Mesenchymal Stem Cells Promote a Primitive Phenotype CD34+c-kit+ in Human Cord Blood-Derived Hematopoietic Stem Cells during Ex Vivo Expansion
Umbilical cord blood-CD34+ cells were cultured in the presence or absence of bone marrow-mesenchymal stem cells and/or cytokines for three and seven days. CD34+ cell proliferation was evaluated using the CSFE method and cell phenotype was determined by CD34, c-kit, CD33, CD38, HLA-DR, cyCD22 and cyCD3 detection. Cell clonogenic ability was also assessed. [Cell Mol Biol Lett] Abstract

Human Placenta-Derived Mesenchymal Stem Cells Suppress T Cell Proliferation and Support the Culture Expansion of Cord Blood CD34+ Cells: A Comparison with Human Bone Marrow-Derived Mesenchymal Stem Cells
Human placenta-derived mesenchymal stem cells (hPMSCs) efficiently enhanced the expansion of CD34+ cells from umbilical cord blood compared with human bone marrow-derived mesenchymal stem cells. Furthermore, hPMSCs maintained the expression of adhesion molecules in CD34+ cells. [Tissue Cell] Abstract

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REVIEWS

Haploidentical Hematopoietic Stem Cell Transplantation with Unmanipulated Granulocyte Colony Stimulating Factor Mobilized Marrow and Blood Grafts
This article summarizes recent improvements and progress with unmanipulated haploidentical blood and marrow transplantation (HBMT) and discusses the difference in outcomes between patients receiving HBMT and those receiving unmanipulated granulocyte colony stimulating factor mobilized haploidentical peripheral blood grafts as allografts. [Curr Opin Hematol] Abstract

Stem Cell Therapy in Equine Tendon Injury
Umbilical cord blood-derived stem cells may provide an alternate source of stem cells that promote improved regeneration of tendon tissue. A more naïve cell population, these cells may have a greater rate of engraftment, as well as an increased ability to secrete bioactive factors and recruit additional reparative cells. [J Anim Sci] Abstract

World Stem Cell Summit

INDUSTRY NEWS

Federal Government Renews Contract for Collecting and Maintaining National Stem Cell Transplantation Database
The Medical College of Wisconsin Center for International Blood and Marrow Transplant Research successfully competed for, and was awarded, renewal of the Stem Cell Therapeutics Outcomes Database contract with the U.S. Health Resources and Services Administration. [Medical College of Wisconsin]
Press Release

NCIS/NUH Stem Cell Transplant Program Receives International Accreditation
The hematopoietic stem cell transplantation program at the National University Cancer Institute (NCIS) and National University Hospital (NUH) has received internationally-recognized accreditation by the Foundation for the Accreditation of Cellular Therapy (FACT) at the University of Nebraska Medical Center. The program at NCIS and NUH is the first and only one in Asia to be recognized so far. [National University Hospital]
Press Release

Cord Blood Registry Named Bioscience Company of the Year
Cord Blood Registry® was named 2012 Bioscience Company of the Year by AZBio, a not-for-profit trade association supporting the growth of Arizona’s bioscience industry. [Cord Blood Registry] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Keystone Symposia on Molecular and Cellular Biology: Stem Cell Regulation in Homeostasis and Disease
February 24-March 1, 2013
Banff, Canada

View our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

Product Quality Scientist (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Research Associate – Quality Assurance (University of California)

Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)

Research Associate in Stem Cell Biology – Cardiovascular Regeneration (CReATe Fertility Centre)

Senior Research Technologist – Hematology (St. Jude Children’s Research Hospital)

Postdoctoral Fellow in Stem Cell Biology (University of Texas Medical School at Houston)


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