Volume 5.01 | Jan 10

Cord Blood News 5.01 January 10, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Mesenchymal Stem Cells Prevent Hydrocephalus after Severe Intraventricular Hemorrhage
This study determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocephalus development and attenuates brain damage after severe intraventricular hemorrhage in newborn rats. [Stroke] Abstract

New StemSpan(TM) SFEM II - for optimal CD34+ cell expansion of bone marrow and cord blood cells
PUBLICATIONS (Ranked by impact factor of the journal)

Characterization of Pluripotent Stem Cells
This protocol provides a description of all the immunodetection procedures necessary to characterize mouse and human stem cell lines in different circumstances. [Nat Protoc] Full Article

Homing of Regulatory T Cells to Human Skin Is Important for the Prevention of Alloimmune-Mediated Pathology in an In Vivo Cellular Therapy Model
To test the hypothesis that different populations of regulatory T cells (Treg) display distinct efficacy in vivo based on their expression of tissue-specific homing molecules, the authors evaluated the activity of human Treg derived from two disparate sources in a model of human skin transplantation. Treg were derived from adult blood or cord blood and expanded in vitro. [PLoS One] Full Article

HHV-6 Cell Receptor CD46 Expression on Various Cell Subsets of Six Blood and Graft Sources: A Prospective Series
Investigators prospectively compared the human herpes virus (HHV-6) cell receptor CD46 expression on various cell subsets of three freshly harvested blood sources on one hand and of three graft sources on the other hand. 52 samples were used for the purpose of this study. They were issued from peripheral blood (PB), G-CSF mobilized PB, cord blood (CB), unmanipulated bone marrow, leukapheresis product and thawed CB graft. [J Clin Virol] Abstract

Outcome of Respiratory Syncytial Virus Lower Respiratory Tract Disease in Hematopoietic Cell Transplant Recipients Receiving Aerosolized Ribavirin: Significance of Stem Cell Source and Oxygen Requirement
Researchers evaluated the effect of transplant and treatment factors on overall survival, mortality from respiratory failure, and pulmonary function among 82 hematopoietic cell transplantation recipients who had respiratory syncytial virus lower respiratory tract disease. All patients received aerosolized ribavirin. In multivariable analyses, only the use of marrow or cord blood as graft source and oxygen requirement remained independently associated with overall mortality and death due to respiratory failure. [Biol Blood Marrow Transplant] Abstract

Some Viral miRNAs Were Up-Regulated in Megakaryocytes Incubated with ITP Plasma
Researchers investigated whether viral microRNAs (miRNAs) are involved in the pathogenesis of immune thrombocytopenia (ITP) for example by modulating the production of megakaryocytes. Plasma samples from adult patients with acute ITP or healthy volunteers were added to the culture system wherein umbilical cord blood mononuclear cells were proliferating into megakaryocytes. [Eur J Haematol] Abstract

DNA Damage Response in CD133+ Stem/Progenitor Cells from Umbilical Cord Blood: Low Level of Endogenous Foci and High Recruitment of Tumor Suppressor p53 Binding Protein 1
Scientists examined the repair of radiation-induced DNA double-strand breaks in CD133+ umbilical cord blood cells. [Int J Radiat Biol] Abstract

Radiosensitivity of Human Hematopoietic Stem/Progenitor Cells
The radiosensitivity of human lineage-committed myeloid hematopoietic stem/progenitor cells (HSPCs) was studied. The present results suggest that there are large individual differences in the surviving fraction of HSPCs contained in both adult peripheral blood and fetus/neonate cord blood. [J Radiol Prot]
Abstract | Full Article

Expression of Scleraxis and Tenascin C in Equine Adipose and Umbilical Cord Blood Derived Stem Cells Is Dependent Upon Substrata and FGF Supplementation
Investigators aimed to determine the expression of scleraxis and tenascin C, two markers of tenocytes, in adipose and umbilical cord blood stem cells during culture on various substrata and in response to fibroblast growth factor (FGF) treatment. [Cytotechnology] Abstract

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REVIEWS
Cord Blood Transplantation in Aplastic Anemia
For patients with inherited BM failure (BMF) or those with acquired BMF who fail immunosuppressive therapy and who lack a suitable alternative donor, the prognosis remains poor. Umbilical cord blood transplantation has extended the availability of hematopoietic stem cell transplantation in the absence of a suitable donor. [Bone Marrow Transplant] Abstract
INDUSTRY NEWS

NeoStem’s Subsidiary, Progenitor Cell Therapy, and Hackensack University Medical Center Enter into a Cell Processing and Storage Services Agreement
NeoStem, Inc. and its subsidiary, Progenitor Cell Therapy, LLC (PCT) and Hackensack University Medical Center (HackensackUMC) announced that HackensackUMC has renewed its engagement of PCT’s services for processing and storage of a variety of cell types used therapeutically by the hospital. HackensackUMC will use the services of PCT for processing and storage services for peripheral blood progenitor cells, donor leukocytes, bone marrow and cord blood, as well as for further assays, storage, retrieval and transportation. [NeoStem, Inc.] Press Release

Sanford-Burnham Medical Research Institute and Intrexon Corporation Establish Collaboration to Accelerate Stem Cell Research
Sanford-Burnham Medical Research Institute and Intrexon Corporation announced a new collaboration to accelerate stem cell research. [Intrexon Corporation] Press Release

POLICY NEWS

Stem Cell Lawsuit Finally Over
The Supreme Court rejected a request to ban U.S.-funded research on human embryonic stem cells (hESCs). The decision brings to an end a long legal battle that has cast a shadow over hESC studies for over three years. [Supreme Court, United States] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW The 3rd International Congress on Controversies in Cryopreservation of Stem Cells, Reproductive Cells, Tissue and Organs (CRYO)
March 21-23, 2013
Berlin, Germany

View our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc.)

Research Technologist – Stem Cells and Cancer (Massachusetts General Hospital & Harvard Medical School)

Postdoctoral Position (University of Iowa College of Medicine)

Postdoctoral Research Associate (Washington University in St Louis – School Of Medicine)

Postdoctoral Research Scientist (Anthony Nolan/University College London)

Postdoctoral Fellow (University of Michigan – Ann Arbor)


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