Volume 5.13 | Apr 4

Cord Blood News 5.13 April 4, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
IL-4Rα on CD4+ T Cells Plays a Pathogenic Role in Respiratory Syncytial Virus Reinfection in Mice Infected Initially as Neonates
The data demonstrate, for the first time, that IL-4Rα is up-regulated in vitro on human CD4+ T cells from cord blood following RSV stimulation and in vivo on mouse pulmonary CD4+ T cells upon reinfection of mice, initially infected as neonates. [J Leukoc Biol] Abstract

New StemSpan(TM) SFEM II - for optimal CD34+ cell expansion of bone marrow and cord blood cells
PUBLICATIONS (Ranked by impact factor of the journal)

C/EBPα Is Required for Development of Dendritic Cell Progenitors
Investigators report the transcription factor C/EBPα coordinates the development of progenitor cells required for production of multiple categories of dendritic cells (DCs). C/EBPα was needed for differentiation from stem/progenitor cells to common DC progenitors (CDP), but not for transition of CDP to mature DCs. [Blood] Abstract

Disease Status and Stem Cell Source Impact on the Results of Reduced Intensity Conditioning Transplant for Hodgkin Lymphoma: A Retrospective Study from the French Society of Bone Marrow Graft Transplantation and Cellular Therapy
Researchers retrospectively analyzed 191 patients who underwent reduced intensity allogeneic stem cell transplantation for relapsed or refractory Hodgkin lymphoma and whose data were reported to the French registry. Data suggest that the use of peripheral blood should be preferred whereas umbilical cord blood should be used with caution. [Haematologica] Abstract | Full Article

AF-MSCs Fate Can Be Regulated by Culture Conditions
In previous studies, the authors isolated and expanded fetal mesenchymal stem cells (MSCs) from second-trimester amniotic fluid (AF) and characterized them based on their phenotype, pluripotency and proteomic profile. In the present study, they investigated the plasticity of these cells based on their differentiation, dedifferentiation and transdifferentiation potential in vitro. [Cell Death Dis] Full Article

Novel Single-Cell Functional Analysis of Red Blood Cells Using Laser Tweezers Raman Spectroscopy: Application for Sickle Cell Disease
Laser tweezers Raman spectroscopy was used to characterize the oxygenation response of single normal adult, sickle, and cord blood red blood cells to an applied mechanical force. Individual cells were subjected to different forces by varying the laser power of a single-beam optical trap, and the intensities of several oxygenation-specific Raman spectral peaks were monitored to determine the oxygenation state of the cells. [Exp Hematol] Abstract

Human Amniotic Fluid Stem Cells Protect Rat Lungs Exposed to Moderate Hyperoxia
The authors investigated the role of amniotic fluid stem cells in an adult rat model of hyperoxia lung injury. [Pediatr Pulmonol] Abstract

Effects of Connective Tissue Growth Factor on the Regulation of Elastogenesis in Human Umbilical Cord-Derived Mesenchymal Stem Cells
Researchers aimed to analyze the connective tissue growth factor effect on elastin production in umbilical cord-derived mesenchymal stem cells and to determine optimal timing of treatment to maximize elastin production. [Ann Plast Surg] Abstract

NEW STEMvision CB, BM & MPB Algorithms

REVIEWS
Placental Mesenchymal Stem Cells: A Unique Source for Cellular Cardiomyoplasty
The authors discuss and compare the characteristics of placenta-derived mesenchymal stem cells as a novel alternative cell source for cellular cardiomyoplasty. [Ann Thorac Surg] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
INDUSTRY NEWS

China Cord Blood Corporation Received AABB Accreditation
China Cord Blood Corporation announced that the cord blood bank operated by its Beijing subsidiary has been granted the AABB Accreditation, as a certification of its quality excellence of providing cord blood processing and storage services. [China Cord Blood Corporation] Press Release

ThermoGenesis Announces New AXP® Customer in Portugal: Crioestaminal Is a Leading Cord Blood Bank in Europe
ThermoGenesis Corp. said equipment is on order for its AXP® AutoXpress® System (AXP) from Crioestaminal, a leading cord blood stem cell bank located in Cantanhede, Portugal. [ThermoGenesis Corp.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW World Biotechnology Congress 2013
June 3-6, 2013
Boston, United States

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

Early Stage Researcher PhD Posts – DECIDE ITN (The University of Birmingham)

Postdoctoral Researcher – NK/T Cells (The Ohio State University – Comprehensive Cancer Center)

Postdoctoral Position – Stem Cell Research (University of Washington)

Lecturer or Reader – Associate Professor (University of Reading)

Cord Blood Laboratory Manager (Puget Sound Blood Center)

Medical Technologist I – Confocal Microscopy & Live Cell Imaging Specialist (King Abdullah International Medical Research Center)

Postdoctoral Positions (Stony Brook University)

Postdoctoral Position – Stem Cell Biology (St. Jude Children’s Research Hospital)


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